Inhibitory effect of oral doxycycline on neovascularization in a rat corneal alkali burn model of angiogenesis.

Purpose: To examine the efficacy of oral doxycycline treatment (as compared to oral and topical dexamethasone) for inhibiting corneal neovascularization (CNV).

Methods: Following corneal alkali burn, rats were treated daily with oral doxycycline, oral dexamethasone, or topical dexamethasone for 14 days. Control rats were injured but were not treated.