Publications by authors named "Yan Ran Sheng"
Efferocytosis is defined as the highly effective phagocytic removal of apoptotic cells (ACs) by professional or non-professional phagocytes. Tissue-resident professional phagocytes ("efferocytes"), such as macrophages, have high phagocytic capacity and are crucial to resolve inflammation and aid in homeostasis. Recently, numerous exciting discoveries have revealed divergent (and even diametrically opposite) findings regarding metabolic immune reprogramming associated with efferocytosis by macrophages.
View Article and Find Full Text PDFHeme induced progesterone-resistant profiling and promotion of endometriosis in vitro and in vivo.
Biochim Biophys Acta Mol Basis Dis
October 2023
Endometriosis is an estrogen-dependent, progesterone-resistant gynecological disease with an unknown pathogenesis. Compared to women without endometriosis, women with endometriosis have a remarkably high heme level in the peritoneal fluid. To further investigate the pathomechanisms of heme in endometriosis, we aimed to identify the dysregulated expression of heme-trafficking proteins, such as PGRMC1/2 that are also receptors that mediate the non-genomic responses to progesterone, and heme-degrading enzymes between ectopic endometrial stromal cells and their normal counterparts.
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- Efferocytosis, the process where macrophages clear apoptotic cells during embryo implantation, is linked to the immune behavior of decidual macrophages (dMΦs) and can affect pregnancy outcomes.
- The study discovered that in patients with recurrent pregnancy loss (RPL), there was a disruption in the IL-33/ST2 signaling pathway, leading to increased apoptotic cells and altered metabolism in dMΦs, which contributed to the polarization toward a more inflammatory M1 phenotype.
- Furthermore, the positive feedback loop involving IL-33/ST2 and AXL in efferocytosis may drive pregnancy failure, as demonstrated in both human samples and experiments with IL-33 knockout mice, highlighting the importance of immunometabolism
Heme oxygenase 1 (HO-1, encoded by the HMOX1 gene) is the rate-limiting enzyme that catalyzes heme degradation, and it has been reported to exert antioxidative effects. Recently, decidualization has been reported to confer resistance to environmental stress signals, protecting against oxidative stress. However, the effects and regulatory mechanism of HO-1 in decidual stromal cells (DSCs) during early pregnancy remain unknown.
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- * Over three years, 1556 miscarriage specimens were analyzed, discovering chromosomal abnormalities in about 57.52% of cases and identifying 346 CNVs linked to RPL.
- * Significant duplications in specific chromosome locations were found more frequently in RPL cases, suggesting a genetic basis for RPL, and potential candidate genes and pathways were identified to aid future diagnostics in Chinese women.
Article Synopsis
- Endometriosis (EMS) is a chronic condition where tissue similar to the uterine lining grows outside the uterus, causing inflammation and pain.
- Recent findings show that patients with EMS have higher levels of heme, a byproduct from broken down red blood cells, in their peritoneal fluid compared to those without the condition.
- This excess heme appears to impair the ability of peritoneal macrophages (a type of immune cell) to clear debris, suggesting a mechanism for the compromised immune response observed in EMS patients.
Efferocytosis, which is known as the phagocytic clearance of dying cells by professional as well as non-professional phagocytes, including a great number of intracellular/extracellular factors and signals, is interrelated with the immune system, contributing to local and systemic homeostasis, especially in tissues with high constitutive rates of apoptosis. Accumulating studies have indicated that immune dysregulation is associated with the pathogenesis of the female reproductive system, which causes preeclampsia (PE), recurrent spontaneous abortion (RSA), ruptured ectopic pregnancy, and so on. And some studies have revealed the pleiotropic and essential role of efferocytosis in these obstetrical disorders.
View Article and Find Full Text PDFProblem: To explore whether IL-33/ST2 axis modulates the polarization and efferocytosis of decidual macrophages (dMφs).
Method Of Study: The phenotype characteristics of dMφs from both normal pregnant women and recurrent spontaneous abortion (RSA) patients were determined by real-time polymerase chain reaction (RT-PCR) and flow cytometry (FCM). Then, the efferocytosis and expression of IL-33 and its receptor (ST2) in dMφs were analyzed by FCM.