Enhanced π-conjugation in hybridized local and charge transfer emitters for efficient red OLEDs and bioimaging.

Red-emitting materials have significantly advanced the development of materials for OLEDs and bioimaging. However, traditional red dyes often suffer from the 5 % external quantum efficiency (EQE) limit and aggregation-caused quenching (ACQ), which impede their practical applications. Herein, two red-emitting materials, TPA-QP and Cz-Ph-QP were designed and synthesized with donor-acceptor (D-A) structures.

Ginsenoside Rg1 alleviates chronic stress-induced depression in rats by targeting Cx43-YAP axis.

Although significant progress has been made in the development of antidepressants, a large subpopulation of individuals remains unresponsive to existing treatments. Ginsenoside Rg1 (Rg1), a natural compound with well-defined antidepressant effects and low-cost administrations, holds therapeutic promise but requires mechanistic elucidation for clinical translation. Based on our previous finding that Rg1 rescued astrocytic connexin43 (Cx43) downregulation in depression models, we investigated its brain-wide effects and molecular mechanisms in chronic unpredictable stress (CUS)-induced rats.

Predictors of severity and onset timing of immune-related adverse events in cancer patients receiving immune checkpoint inhibitors: a retrospective analysis.

Objective: To identify predictors of all-grade, grade ≥ 3, and onset time of immune-related adverse events (irAEs) in cancer patients undergoing immune checkpoint inhibitors (ICIs) therapy.

Methods: This retrospective analysis included cancer patients treated with ICIs at Chongqing Medical University Second Affiliated Hospital from 2018 to 2024. Logistic regression and Cox regression analyses were used to identify predictors of all-grade and grade ≥ 3 irAEs and the time of irAE onset.

STModule: identifying tissue modules to uncover spatial components and characteristics of transcriptomic landscapes.

Here we present STModule, a Bayesian method developed to identify tissue modules from spatially resolved transcriptomics that reveal spatial components and essential characteristics of tissues. STModule uncovers diverse expression signals in transcriptomic landscapes such as cancer, intraepithelial neoplasia, immune infiltration, outcome-related molecular features and various cell types, which facilitate downstream analysis and provide insights into tumor microenvironments, disease mechanisms, treatment development, and histological organization of tissues. STModule captures a broader spectrum of biological signals compared to other methods and detects novel spatial components.

Gibberellin signalling mediates nucleocytoplasmic trafficking of Sucrose Synthase 1 to regulate the drought tolerance in rice.

The Green Revolution (GR) has substantially improved cereal crop yields and enhanced adaptation to diverse environmental challenges. However, the molecular and cellular mechanisms involving GR-related genes that regulate drought tolerance in plants remain largely unclear. Here, we reveal that the gibberellin (GA) signalling repressor SLENDER RICE 1 (SLR1) negatively regulates the abundance of the dehydration-responsive protein OsBURP3 to enhance drought tolerance in rice.

A VgrG2b fragment cleaved by caspase-11/4 promotes infection through suppressing the NLRP3 inflammasome.

The T6SS of plays an essential role in the establishment of chronic infections. Inflammasome-mediated inflammatory cytokines are crucial for host defense against bacterial infections. We found that infection activates the non-canonical inflammasome in macrophages, yet it inhibits the downstream activation of the NLRP3 inflammasome.

Intratumoral Fusobacterium nucleatum Recruits Tumor-Associated Neutrophils to Promote Gastric Cancer Progression and Immune Evasion.

Intratumoral microbiota can impact the development and progression of many types of cancer, including gastric cancer (GC). A better understanding of the precise mechanisms by which microbiota support GC could lead to improved therapeutic approaches. Here, we investigated the effect of intratumoral microbiota on the tumor immune microenvironment (TIME) during GC malignant progression.

A formaldehyde-free, high-performance soy protein-based adhesive enhanced by hyperbranched sulfuretted polyamidoamine-epichlorohydrin resin.

A self-synthesized hyperbranched sulfuretted polyamidoamine-epichlorohydrin (PCDME) resin was developed to enhance high-temperature soybean meal (HSM) protein-based adhesives. In PCDME-modified HSM adhesives, a multi-crosslinked network is built based on ring-opening reactions, disulfide bond rearrangement, electrostatic interactions, and hydrogen bonding between the active groups in PCDME resins and HSM proteins. This results in the HSM-based adhesive with significantly enhanced internal cohesion, thermal stability, moisture resistance and bonding strength.

N-methylguanosine tRNA modification promotes gastric cancer progression by activating SDHAF4-dependent mitochondrial oxidative phosphorylation.

N-methylguanosine (mG) tRNA modification is closely implicated in tumor occurrence and development. However, the precise function and molecular mechanisms of mG tRNA modification in gastric cancer (GC) remain unclear. In this study, we evaluated the expression and function of methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) in GC and elucidated the mechanisms underlying the role of METTL1/WDR4-mediated mG tRNA modifications in promoting GC progression.

Developing nondestructive sensitive detection for smoke-exposure assessment in wine via advanced Raman spectroscopy.

Wildfire smoke has become an increasing problem due to climate change and global warming, and rapid smoke analysis is vital for the wine industry. This work demonstrates a new approach for determining volatile phenol (guaiacol) in wine via surface-enhanced Raman spectroscopy (SERS) and femtosecond stimulated Raman spectroscopy (FSRS). The results showed that several marker bands become particularly enhanced, enabling the detection of guaiacol at lower concentrations than spontaneous Raman.

The potential, challenges, and prospects of Panax quinquefolium L. polysaccharides as future multipurpose biomacromolecules.

Panax quinquefolium L., a renowned medicinal and edible plant with a long history, was once referred to as "The King of Herbs". Due to its excellent medicinal and nutritional values, it has been developed into a variety of functional products.

Molecular mechanism of macrophage polarization regulating the cell senescence of nucleus pulposus during intervertebral disc degeneration.

In orthopedics, intervertebral disc degeneration (IVDD) is a prevalent chronic condition whose cellular molecular processes are yet unclear. The objective of this research was to uncover the molecular causes of aging and identify the immunological microenvironmental alterations and immune cell infiltration in IVDD. IVDD gene datasets were obtained using GeneCards, and gene expression profiles were chosen from the Gene Expression Synthesis database (GSE244889).

Advanced Dual-Cross-Linking Strategy for Upgrading Formaldehyde-Free Olefin Adhesives.

Adhesives are extensively used in industry and construction, with formaldehyde-free options gaining popularity due to their enhanced safety and chemical stability. However, their water resistance remains a significant limitation. In this study, a simple and efficient strategy based on a physicochemical dual cross-linking synergistic network was proposed to develop a new formaldehyde-free adhesive (IBMP-BT).

Comment on: FLT3 ligand kinetic profile predicts response to treatment in patients with high-risk myelodysplastic syndrome / chronic myelomonocytic leukemia receiving CPX-351: a study from the Groupe Francophone des Myélodysplasies.

Not available.

Enhanced ZBTB10 expression induced by betulinic acid inhibits gastric cancer progression by inactivating the ARRDC3/ITGB4/PI3K/AKT pathway.

Background: Gastric cancer (GC) ranks as the fourth leading cause of cancer-related deaths worldwide, with most patients diagnosed at advanced stages due to the absence of reliable early detection biomarkers.

Methods: RNA-sequencing was conducted to identify the differentially expressed genes between GC tissues and adjacent normal tissues. CCK8, EdU, colony formation, transwell, flow cytometry and xenograft assays were adopted to explore the biological function of ZBTB10 and betulinic acid (BA) in GC progression.

Extraction, Purification, Structural Characteristics, Biological Activities, and Applications of Polysaccharides from : A Review.

Blume is a well-known medicinal and edible plant in China, celebrated for its extensive history in traditional medicine and functional food applications. Among its key bioactive components, polysaccharides have drawn significant attention from researchers in the fields of health food and medicine due to their potential health benefits. Recent studies have revealed various biological activities associated with polysaccharides, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, anti-aging, immune regulation, and neuroprotective properties.

Cyanamide-Based Cyclization Reactions for Nitrogen-Containing Heterocycles Synthesis.

Nitrogen-containing heterocycles, such as indoles and quinolines, serve as the key scaffolds in numerous pharmaceuticals, pesticides, and natural products. The synthesis methods of nitrogen-containing heterocycles show significant scientific and industrial value. As a chemical intermediate featuring dual functional groups, cyanamide plays a crucial role in organic synthesis, directly affecting the development of new drugs and the design of new materials.

Single-Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions.

Background: The molecular of intervertebral disc degeneration (IVDD) is still unclear. When it comes to treating decoction, traditional Chinese medicine is effective. In particular, the Duhuo (Radix Angelicae Biseratae) may be particularly helpful.

Mechanistic Insights into Kaempferol's Therapeutic Effects on Postmenopausal Osteoporosis: A Proteomic and Experimental Validation in Ovariectomized Rats.

Background: Postmenopausal Osteoporosis (PMOP) is characterized by decreased bone mass and deterioration of bone microarchitecture, leading to increased fracture risk. Current treatments often have adverse effects, necessitating safer alternatives. Kaempferol, a flavonoid identified as a key active component of the traditional Chinese medicine Yishen Gushu formula, has shown promise in improving bone health, but its mechanisms in PMOP treatment remain unclear.

DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer.

Mitochondrial oxidative phosphorylation (OXPHOS) is a therapeutic vulnerability in glycolysis-deficient cancers. Here we show that inhibiting OXPHOS similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-derived CRC xenografts. While the increased glycolytic activity rapidly replenished the ATP pool, it did not restore the reduced production of aspartate upon OXPHOS inhibition.

FGF21 Exhibits Neuroprotective Effects by Promoting 5-HTR-FGFR1 Heteroreceptor Complexes and Triggering MEK-ERK Signaling Pathway.

Approaches of promoting a neural milieu permissive for plasticity and resilience against neuronal injury are important strategies for the treatment of a range of neurological disorders. Fibroblast growth factor 21 (FGF21) which is known for its role as a potent regulator of glucose and energy metabolism has also proved to be neuroprotective against various mental diseases. However, the underlying molecular mechanisms remain elusive.

Safety After Dark: A Privacy Compliant and Real-Time Edge Computing Intelligent Video Analytics for Safer Public Transportation.

Public transportation systems play a vital role in modern cities, but they face growing security challenges, particularly related to incidents of violence. Detecting and responding to violence in real time is crucial for ensuring passenger safety and the smooth operation of these transport networks. To address this issue, we propose an advanced artificial intelligence (AI) solution for identifying unsafe behaviours in public transport.

Disrupting EDEM3-induced M2-like macrophage trafficking by glucose restriction overcomes resistance to PD-1/PD-L1 blockade.

Background: Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer-associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need for new treatment strategies.

Methods: Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T cell coculture, crystal violetstaining, ELISA, metabonomic and clinical tumour samples were conducted to assess the role of EDEM3 in immune escape and itsmolecular mechanisms.

Study protocol: A national cross-sectional study on psychology and behavior investigation of Chinese residents in 2023.

Introduction: This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.

Comparative analysis of the complete chloroplast genome of Pueraria provides insights for species identification, phylogenetic relationships, and taxonomy.

Background: Pueraria is an edible and medicinal raw material, which is of great value to the pharmaceutical and food industries. Nonetheless, due to morphological diversity and complex domestication history, the classification of Pueraria plants is ambiguous. As the varieties on the market are mixed, the species are difficult to distinguish, and their morphological characteristics are similar to the physical and chemical properties.