CircTAOK1 regulates high glucose induced inflammation, oxidative stress, ECM accumulation, and apoptosis in diabetic nephropathy via targeting miR-142-3p/SOX6 axis.

Background: Diabetic nephropathy (DN) is a complication caused by diabetes. Circular RNAs (circRNAs) are a kind of RNA with a closed circular structure, which has high stability and is involved in many disease-related processes. The mechanism of circRNA TAO kinase 1 (circTAOK1) in the pathogenesis and development of DN is unclear.

Circ_0068087 knockdown attenuates high-glucose-induced human tubular epithelial cell injury in a microribonucleic acid/progestin and adipoQ receptor 3-dependent manner in diabetic nephropathy.

Aims/introduction: Previous studies have shown that circular ribonucleic acid mediates the occurrence of diabetic nephropathy. This study aimed to analyze the effects of circ_0068087 on high-glucose (HG)-induced human kidney 2 (HK2) cell dysfunction.

Materials And Methods: Circ_0068087, miR-580-3p, and progestin and adipoQ receptor 3 (PAQR3) expression were detected by quantitative reverse transcription polymerase chain reaction.

Utilizing the energy transfer mechanism to realize color tunable luminescence.

Bi/Eu co-doped phosphors can realize multi-color luminescence by adjusting the concentration ratio, which makes it possible to manually control the emission color. On this basis, a series of Bi/Eu co-doped phosphors SrLaGaO:Bi,Eu were prepared. The existence of energy transfer from Bi to Eu was verified by spectral analysis.

Utilization of genetic biomarkers testing and its associated factors in advanced colorectal cancer patients in China: a nationwide multicenter clinical epidemiological study.

Background: Biomarkers are a key tool in early detection, prognostication, survival, and predicting treatment response of colorectal cancer (CRC). However, little is known about biomarker testing for CRC patients in real-life clinical practice in China. This study aimed to address the usage of biomarker testing and analyze factors related to its acceptance among Chinese patients with advanced CRC.

Out-of-pocket medical expenditure and associated factors of advanced colorectal cancer in China: a multi-center cross-sectional study.

Background: Colorectal cancer (CRC) causes a substantial disease burden in China. Information on the medical expenditure of CRC patients is critical for decision-makers to allocate medical resources reasonably, however, relevant data is limited in China, especially advanced CRC. The aim of this survey was to quantify the out-of-pocket medical expenditure of advanced CRC and explore associated factors.

The choice of medical facility and associated factors among Chinese advanced colorectal cancer patients: a cross-sectional multi-center study.

Background: Colorectal cancer (CRC) poses a significant public health burden worldwide. The investigation of the choice of medical facility among CRC patients is helpful for understanding access to health services and improving quality of oncology services to optimize health outcomes. However, there are limited studies on the topic.

Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey.

Background: Colorectal cancer (CRC) is one of the most common cancers in China, and most CRC patients have already reached an advanced stage by the time of initial diagnosis. Due to the loss of health as a result of cancer, it has consequence on the treatment which may affect the psychophysical and social impairment of CRC patients. These indicators (psychophysical, function and social impairment) affect the health-related quality of life (HRQOL).

Status and associated factors of cross-regional healthcare-seeking among patients with advanced colorectal cancer in China: a multicenter cross-sectional study.

Background: The imbalanced allocation of medical resources leads to the occurrence of cross-regional healthcare-seeking in China. Due to the low cure rate, advanced colorectal cancer (CRC) patients may seek cross-regional healthcare for high-level medical facilities. Investigating status of cross-regional healthcare-seeking and its associated factors among advanced CRC patients is important for policymakers to understand access to health services and improve the quality of oncology services.

Crystal structure, theoretical studies and luminescent properties of a new borate NaGdBO with one-dimensional broad-banded anionic framework.

Inorganic borate compounds exhibit significant diversity in their structure types, which are associated with interesting optical and magnetic properties. In our work, a new rare-earth polyborate NaGdBO was prepared with an infinite one-dimensional (1D) broad-banded framework of [BO] running along the a-axis, in which large Gd and Na ions reside to ensure cohesion and neutrality of the structure. The basic fundamental building block (FBB) of [BO] is BO, which is composed of five BO and three BO groups and can be written as 5Δ3□: 〈2Δ□〉-〈Δ2□〉〈2Δ□〉.

Efficacy and safety of incretin-based therapies in patients with nonalcoholic fatty liver disease: A protocol for a systematic review and meta-analysis.

Background: Nonalcoholic fatty liver disease (NAFLD) is seriously affecting the general health due to its high prevalence and associated risk of liver-related consequences and extrahepatic chronic complications. New drugs are urgently needed for the treatment of NAFLD. The purpose of this meta-analysis is to assess the efficacy of incretin-based therapies in patients with NAFLD.

Thermally Stable Phosphor KBa(PO):Eu with Broad-Band Cyan Emission Caused by Multisite Occupancy of Eu.

The relationship between the structure and properties is always a hot topic in the luminescent material field. In this work, a new phosphor KBa(PO):Eu (KBP:Eu) was prepared by a high-temperature solid-state reaction method and characterized by X-ray diffraction, energy-dispersive X-ray spectroscopy, photoluminescence (PL), and electroluminescence studies. The polyphosphate host KBP offers three lattice environments (K1, Ba1, and Ba2) for Eu ions to realize broad-band emission from 380 to 700 nm under 345 nm excitation.

A new disordered langbeinite-type compound, KTbTaPO, and Eu-doped multicolour light-emitting properties.

For the first time, a new langbeinite-type phosphate, namely potassium terbium tantalum tris(phosphate), KTbTa(PO), has been prepared successfully using a high-temperature flux method and has been structurally characterized by single-crystal X-ray diffraction. The results show that its structure can be described as a three-dimensional open framework of [TbTa(PO)] interconnected by K ions. The Tb and Ta cations in the structure are disordered and occupy the same crystallographic sites.

[Effects of protease inhibitors on the activities of midgut proteases in Callosobruchus chinensis (Linnaeus) larvae.].

To clarify the effects of protease inhibitors on the activities of midgut proteases in Callosobruchus chinensis (L.) larvae, the inhibitory effects of four kinds of protease inhibitors on the activities of midgut proteases of C. chinensis larvae were examined in vitro and in feeding conditions with indoor artificial insect inoculation.

Comparative Study on Temperature-Dependent CO Sorption Behaviors of Two Isostructural N-Oxide-Functionalized 3D Dynamic Microporous MOFs.

By functionalization of the achiral carboxylate-based pyridine-N ligand 2,2'-bipyridine-3,3'-dicarboxylate (Hbpda) with N-oxide groups, the axially chiral ligand 2,2'-bipyridine-3,3'-dicarboxylate 1,1'-dioxide (Hbpdado) has been obtained. On the basis of Hbpdado and auxiliary N-donor ligands, two isostructural 3D dynamic porous Cu(II) metal-organic frameworks (MOFs), {[Cu(bpdado)(L)]·3HO} (L = 1,2-bis(4-pyridyl)ethane (bpa), trans-1,2-bis(4-pyridyl)ethene (bpe) for 1 and 2, respectively), have been synthesized, which contain N-oxide "open donor sites" (ODSs) and carboxyl sites on the pore surfaces. The modification of pyridine-N into the N-oxide group not only transforms the nonporous structure into a porous framework but also endows the N-oxide group with unique charge-separated plus electron-rich character, which may provide an enhanced affinity toward CO molecules.

Molecular cloning and expression of Hedychium coronarium farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral and wounding/herbivory induced leaf volatile sesquiterpenoids.

Farnesyl pyrophosphate synthase (FPPS EC 2.5.1.

Glucocorticoids decrease body weight and food intake and inhibit appetite regulatory peptide expression in the hypothalamus of rats.

The aim of the present study was to investigate the effects of glucocorticoids (GCs) on appetite and gene expression of the hypothalamic appetite regulatory peptides, neuropeptide Y (NPY), agouti-related protein (AGRP) and cocaine and amphetamine-regulated transcript (CART), in non-obese and obese rats. Both non-obese and obese rats were randomly assigned to three groups: normal saline, low- and high-dose GC groups (NSG, LDG and HDG, respectively), which received an intraperitoneal injection with normal saline (0.2 ml/100 g) or hydrocortisone sodium succinate at 5 and 15 mg/kg, respectively, for 20 days.

Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats.

Objective: Accumulating evidence suggests that adiponectin plays an important role in the genesis of obesity and insulin resistance. Although it has been shown that glucocortocoids (GC) inhibit adiponectin expression in vitro, there exist discrepant results in vivo. In this study, we observe the effect of GC on the serum adiponectin level and adiponectin expression in white adipose tissue (WAT) in male SD rats.

[Research on key technologies of all fiber optic Fourier transform spectrometer].

A noval all fiber optic Fourier transform spectrometer based on single mode fiber Mach-Zehnder interferometer is reported. The authors designed a piezoelectric optical phase modulator with two centimeter scan scale, which was used to replace the moving mirror of traditonal Fourier transform spectrometer. The 1 310 nm DFB laser was used as reference light source to make equal interval sampling of test light source's interferogram, and to eliminate errors of nonlinear modulation.

[Effect of phosphorus deficiency on alternative respiratory pathway and its relation with O2-* accumulation in suspension-cultured tobacco cells].

Effects of phosphorus deficiency on alternative respiratory pathway and its relation with O(-.)(2) production were investigated in two lines of suspension-cultured tobacco cells which have different tolerances to P deficiency. Oxford cells were shown to be much more tolerant than K326.