Publications by authors named "Yan Pang Ke"
Article Synopsis
- The study aimed to create a population pharmacokinetic (PK) model for ciprofol and its major metabolite, M4, and connect it to a pharmacodynamic (PD) model for subjects with different kidney functions.
- A three-compartment model effectively described the PK of unbound ciprofol, and a two-compartment model was suitable for M4, with hemoglobin and uric acid influencing drug clearance.
- The findings concluded that the developed model accurately represents ciprofol's PK and PD, indicating no need for dosage changes in patients with mild to moderate renal impairment.
Aim: The sodium glucose cotransporter 2 (SGLT2) plays an important role in renal glucose reabsorption, thus serves as a new target for the treatment of diabetes. The purpose of this study was to evaluate SHR3824 as a novel selective SGLT2 inhibitor and to characterize its in vivo effects on glucose homeostasis. The effects of chronic administration of SHR3824 on peripheral insulin sensitivity and pancreatic β-cell function were also investigated.
View Article and Find Full Text PDFA series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors.
View Article and Find Full Text PDFA series of novel azobicyclo[3.3.0]octane derivatives were synthesized and evaluated as dipeptidyl peptidase 4 (DPP-4) inhibitors.
View Article and Find Full Text PDFAim: To develop homogeneous calcium mobilization assay for high-throughput screening (HTS) of mas-related gene (Mrg) receptor agonists.
Methods: CHO-K1 cells stably expressing the full-length MrgD receptor and a calcium-sensitive dye were used to develop an HTS assay based on intracellular calcium influx. This method was applied to large-scale screening of a library containing 8000 synthetic compounds and natural product extracts.