Publications by authors named "Yan Lei Chen"
We previously found that epigallocatechin-3-gallate (EGCG) could inhibit the myofibroblast transformation of human Tenon's fibroblasts, however, the underlying mechanism remained unclear. We therefore investigated whether the autophagic regulation involved in the anti-fibrotic function of EGCG. The fibroblasts were subjected to transforming growth factor beta-1 (TGF-β1) induction followed by EGCG treatments.
View Article and Find Full Text PDFInvestigation of self-reported chronic urticaria among adults in grasslands of northern China.
Medicine (Baltimore)
November 2020
Article Synopsis
- The study analyzed the prevalence and characteristics of chronic urticaria (CU) among adults in northern China, revealing a self-reported prevalence of 5.61%.
- It found that CU was more common in women, and a significant portion of cases were linked to seasonal factors, particularly during pollen dispersal seasons.
- Additionally, several health conditions and allergic histories, such as eczema and food allergies, were identified as closely related to CU, highlighting the need for more research on its causes and prevention.
Purpose: To compare ocular anatomy differences of lens subluxation between eyes with or without acute angle closure (AAC).
Methods: This is a retrospective and case-control study. Sixty cases with mild lens subluxation were recruited.
Article Synopsis
- Age-related cataract is a major cause of blindness globally, and the mechanisms behind it are not fully understood.
- This study investigates the role of uric acid (UA) in the development of posterior subcapsular cataract (PSC) by analyzing patient samples and conducting experiments on human lens cells.
- Results indicate that higher levels of UA in the eye's fluid are significantly associated with PSC, suggesting that controlling UA levels could help slow down the disease's progression.
Myofibroblast transformation of human Tenon's fibroblasts severely challenges the outcome of glaucoma filtration surgery. epigallocatechin-3-gallate (EGCG) is considered as a potential reagent to overcome this issue for its anti-fibrosis effect on various human diseases, but it is unclear on the fibrosis of Tenon's fibroblasts. This study was conducted to investigate the effect of EGCG on TGF-β1-induced myofibroblast transformation of human Tenon's fibroblasts.
View Article and Find Full Text PDFSubcutaneous immunotherapy is the only treatment that improves the natural progression of allergic rhinitis and maintains long-term outcomes after discontinuation of the drug. Metabolomics is increasingly applied in the study of allergic diseases, including allergic rhinitis. However, little is known about the discovery of metabolites that can evaluate clinical efficacy and possible mechanisms of pollen subcutaneous immunotherapy.
View Article and Find Full Text PDFBackground: Several studies have shown that the use of antibiotics early in life significantly increases the risk of asthma in children. It is unclear whether antibiotics are more commonly used in patients with allergy-related diseases.
Methods: A multistage, clustered and random sampling with a field-interviewer-administrated survey study was performed to investigate if there was multiple use of antibiotics (MUA) in patients with allergic rhinitis (AR), conjunctivitis, chronic urticaria (CU), and asthma in the grasslands of northern China.