TMT proteomics analysis of intestinal tissue from patients of irritable bowel syndrome with diarrhea: Implications for multiple nutrient ingestion abnormality.

Diarrheal irritable bowel syndrome (IBS-D) is a chronic functional bowel disease with no clear diagnostic markers and no satisfactory treatment strategies. In recent years, the importance of intestinal microstructure and function in IBS-D has been emphasized. However, the intestinal tissue proteomics of IBS-D patients has not been analyzed.

Predicting Parametrial Invasion in Cervical Carcinoma (Stages IB1, IB2, and IIA): Diagnostic Accuracy of T2-Weighted Imaging Combined With DWI at 3 T.

Objective: The objective of our study was to retrospectively evaluate the efficacy of combined analysis of T2-weighted imaging and DWI in the diagnosis of parametrial invasion (PMI) in cervical carcinoma.

Materials And Methods: The clinical records of 192 patients with cervical carcinoma who met the study requirements were reviewed for this retrospective study. The signal intensities of suspicious PMI tissue were assessed on T2-weighted images, DW images, and apparent diffusion coefficient maps independently by two experienced radiologists.

A pair of 3D enantiotopic zinc(ii) complexes based on two asymmetric achiral ligands.

Enantiomorphism and enantioselectivity are critical in biology and many other applications. Herein, we report two 3D chiral MOFs {[Zn(MIDPPA)(1,2,4-btc)(NO)(HO)](HO)} (1L and 1R) based on achiral ligands with high enantiomeric excess and a novel topological type. The internal mechanism of spontaneous chiral symmetry breaking, during the crystallization of chiral MOFs based on achiral ligands, is elucidated for the first time from both structural and theoretical aspects.

Fluorescence Resonance Energy Transfer-based Biosensor Composed of Nitrogen-doped Carbon Dots and Gold Nanoparticles for the Highly Sensitive Detection of Organophosphorus Pesticides.

The present article reports a novel biosensor for organophosphorus pesticides based on fluorescence resonance energy transfer (FRET) between nitrogen-doped carbon dots (NC-dots) and gold nanoparticles (AuNPs). The effective NC-dots/AuNPs assembly through the Au-N interaction results in good fluorescence quenching. Active acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine into -SH containing thiocholine to replace the NC-dots and trigger the aggregation of AuNPs.

Three different metal-organic frameworks derived from a one-pot crystallization and their controllable synthesis.

Three different Co-MOFs, [Co3(L)2(DPDP)]n (1), [Co(HL)(DPDP)]n (2) and {[Co(HL)(1/2DPDP)3(H2O)]·H2O}n (3) (H3L = 4,4',4''-(nitrilotris(methylene))tribenzoic acid, DPDP = 4,4'-(2,5-dibutoxy-1,4-phenylene)dipyridine) have been co-crystallized in a one-pot reaction. Based on the significant differences between the three structures, we adopt solvents to ultimately regulate acquisition of pure crystals of the three compounds.

Effect of intravenous gadolinium-DTPA on diffusion-weighted imaging of brain tumors: a short temporal interval assessment.

Purpose: To determine the effect of intravenous administration of gadolinium (Gd) contrast medium (Gd-DTPA) on diffusion-weighted imaging (DWI) for the evaluation of normal brain parenchyma vs. brain tumor following a short temporal interval.

Materials And Methods: Forty-four DWI studies using b values of 0 and 1000 s/mm(2) were performed before, immediately after, 1 min after, 3 min after, and 5 min after the administration of Gd-DTPA on 62 separate lesions including 15 meningioma, 17 glioma and 30 metastatic lesions.