Publications by authors named "Yan Jing Fan"

Background: Allergic rhinitis (AR) is the most prevalent form of atopic disease. Undaria pinnatifida has potent antioxidative, antidiabetic, and anti-inflammatory properties.

Aims: We investigated the immunomodulatory effect of Undaria pinnatifida extract (UPE) on allergic inflammation in an AR mouse model.

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has traditionally been used as an herbal medicine due to its characteristics that protect against inflammation, hypertension, and mutagenesis. However, the effect of (CSE) on allergic rhinitis (AR) and its underlying mechanisms have yet to be thoroughly investigated. The current study explored the likely effect of CSE on AR in an ovalbumin (OVA)-induced AR mouse model.

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Article Synopsis
  • Asian knotweed's root extract (FJE) was tested for its effects on airway inflammation linked to combined allergic rhinitis and asthma (CARAS) in a mouse model.
  • Mice treated with FJE showed a decrease in allergic responses, including lower levels of IgE and inflammatory cytokines, while enhancing IgG2a levels.
  • FJE also improved histopathological conditions in nasal and lung tissues and influenced the IL-33/TSLP/NF-kB signaling pathway, suggesting its potential as a therapeutic for CARAS.
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Asthma is a chronic airway inflammatory disease listed as one of the top global health problems. BÂN is a well-known medicinal plant in Vietnam with its anti-oxidant, anti-microbial, anti-inflammatory potential, and gastro-protective properties. However, there is no study about extract (PVE) on asthma disease.

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  • A new term, "combined allergic rhinitis and asthma syndrome (CARAS)," describes patients who suffer from both allergic rhinitis and asthma due to an imbalance of TH1/TH2 immune responses and mast cell degranulation.
  • A study tested the effects of an herbal extract, AGE, on CARAS in a mouse model, finding that AGE reduced symptoms like nasal rubbing and sneezing, while also lowering IgE and histamine levels.
  • AGE treatment improved the histological changes in nasal and lung tissues, shifted the immune response towards TH1 favorability by increasing IL-12 and T-bet levels, and significantly suppressed TH2 cytokines, suggesting AGE's potential as a therapeutic option for CARAS
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  • Dryopteris crassirhizoma (DC) exhibits multiple pharmacological effects, including anti-inflammatory properties, which prompted a study to analyze its impact on allergic asthma using a mouse model.
  • The study found that DC reduced inflammatory cell levels and collagen deposition in the lungs, along with modulating cytokine levels by increasing Th1 cytokines and decreasing Th2 cytokines.
  • DC treatment also inhibited the activation of NF-κB signaling pathways and lowered IgE levels, indicating its potential as an anti-inflammatory agent for allergic asthma management.
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Backgroud: The biological effect of phototherapy, which involves using visible light for disease treatment, has attracted recent attention, especially in dermatological practice. Light-emitting diode (LED) irradiation increases dermal collagen level and reduces inflammation. It has been suggested that thermal therapy and LED irradiation can modulate inflammatory processes.

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An ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model was established to investigate whether α-Lipoic acid (LA) has a protective effect against upper respiratory tract inflammation. BALB/c mice were sensitized by intraperitoneal injection and challenged by intranasal application of OVA. Mice were orally administered various doses of LA once daily (2, 10, 50 mg/kg) and dexamethasone (Dex; 2.

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Mangiferin (MF), extracted from mango trees, is considered to have anti-inflammatory, anti-apoptotic, and antioxidant effects. However, its effects on allergic rhinitis (AR), remain unclear. We investigated the mechanisms underlying the protective action of MF in ovalbumin (OVA)-induced AR models.

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