The potential application of natural products in cutaneous wound healing: A review of preclinical evidence.

Under normal circumstances, wound healing can be summarized as three processes. These include inflammation, proliferation, and remodeling. The vast majority of wounds heal rapidly; however, a large percentage of nonhealing wounds have still not been studied significantly.

Orthokeratinized odontogenic cysts: A clinicopathologic study of 159 cases and molecular evidence for the absence of PTCH1 mutations.

Background: Orthokeratinized odontogenic cyst (OOC), a newly designated entity of odontogenic cysts, is an intraosseous jaw cyst that is entirely or predominantly lined by orthokeratinized squamous epithelium. The aim of this study was to report a large series of OOC to substantiate its clinicopathologic profiles and to investigate PTCH1 mutations in OOCs.

Method: The clinicopathologic features of 167 OOCs from 159 patients were analyzed and the immunohistochemical expression of markers related to cell differentiation and proliferation was evaluated.

An Abdominal Registration Technology for Integration of Nanomaterial Imaging-Aided Diagnosis and Treatment.

Image registration technology is a key technology used in the process of nanomaterial imaging-aided diagnosis and targeted therapy effect monitoring for abdominal diseases. Recently, the deep-learning based methods have been increasingly used for large-scale medical image registration, because their iteration is much less than those of traditional ones. In this paper, a coarse-to-fine unsupervised learning-based three-dimensional (3D) abdominal CT image registration method is presented.

Liver segmentation from abdominal CT volumes based on level set and sparse shape composition.

Background And Objective: Liver segmentation from abdominal CT volumes is a primary step for computer-aided surgery and liver disease diagnosis. However, accurate liver segmentation remains a challenging task for intensity inhomogeneity and serious pathologies occurring in liver CT volume. This paper presents a novel framework for accurate liver segmentation from CT images.

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy.

It has been suggested that autophagy protects renal tubular epithelial cells (TECs) from injury in diabetic nephropathy (DN). However, the manner in which the autophagy-lysosome pathway is changed in this state remains unclear. In this study of DN, we investigated the autophagic activity and lysosomal alterations in vivo and in vitro.

[Adsorption kinetics and mechanism of lead (II) on polyamine-functionalized mesoporous activated carbon].

Bagasse mesoporous carbon was prepared by microwave assisted H3 PO4 activation. Amido and imido groups were modified with ethanediamine on the channels' surface of mesoporous carbon through nitric oxidation and amide reaction. The influence of Pb(II) concentration, adsorption time on Pb(II) adsorption on the ethanediamine-modified mesoporous carbon (AC-EDA) was investigated.

[Effect of different tidal volume ventilations on atelectasis in patients during general anesthesia by CT scan].

Objective: To investigate the effect of different tidal volume ventilations on the amount of atelectasis during general anesthesia.

Methods: Twenty adults, ASA physical status I and status II patients, who were scheduled for elective excision of intracranial lesion were randomly divided into 2 groups: Group TV (traditional tidal volume ventilation, 10 mL/kg) and Group LV (low tidal volume ventilation, 6 mL/kg). Atelectasis, as determined by CT and artery blood gas (ABG) analysis, was measured before the anesthesia, after the tracheal intubation, and at the end of the operation, respectively.

[Chemoresistance of CD133(+) tumor stem cells from human brain glioma].

Objective: To explore the multidrug resistance (MDR) mechanism of ABC superfamily transporters in the tumor stem cells(TSC) from human brain glioma tissues.

Methods: Samples of glioma were obtained from 30 patients undergoing microsurgical tumor resection. The CD133(+) cells and CD133(-) cells from these tumor specimens were isolated by magnetic activated cell sorting(MACS).

[Isolation and identification of brain tumor stem cells from human brain neuroepithelial tumors].

Objective: To establish a simplified culture system for the isolation of brain tumor stem cells (BTSCs) from the tumors of human neuroepithelial tissue, to observe the growth and differentiation pattern of BTSCs, and to investigate their expression of the specific markers.

Methods: Twenty-six patients with brain neuroepithelial tumors underwent tumor resection. Two pieces of tumor tissues were taken from each tumor to be dissociated, triturated into single cells in sterile DMEM-F12 medium, and then filtered.

Photo-degradation of acid-red 3B dye catalyzed by TiO2 nanotubes.

TiO2 nanotube precursor was synthesized by the hydrothermal reaction of TiO2 powders with NaOH solution and the properties of the nanotube materials were tuned using different post-treatments. Transmission electron microscopic (TEM) observation revealed that the nanotube could be obtained by either a direct rinse with acid solution or rinse with distilled water followed by acid solution. The results of X-ray diffraction (XRD) and inductively coupled plasma (ICP) analysis indicated that the nanotube material was composed of H2Ti2O5 x H2O.

[Pathogens and drug resistance of nosocomial pneumonia after intracranial surgery].

Objective: To determine the antimicrobial resistance and bacterial distribution of nosocomial pneumonia in neurosurgical patients.

Methods: We analyzed and counted the result of sputum culture, drug sensibilities test, and the rate of nosocomial pneumonia after intracranial surgery of all the patients in the Department of in Neurosurgery our hospital in 2002.

Results: The rate of nosocomial pneumonia after intracranial surgery was 6.

[In vitro gene transfection by magnetic iron oxide nanoparticles and magnetic field increases transfection efficiency].

Objective: To evaluate the feasibility of using iron oxide nanoparticles as gene vector and the effect of magnetic field on efficiency of transfection.

Methods: Iron oxide nanoparticles were prepared by alkaline precipitation of divalent and trivalent iron chloride. The surface of iron oxide nanoparticles was modified by self-assembled poly-L-lysine to form particle complexes (IONP-PLL).