Publications by authors named "Yan Jia-Qi"
Article Synopsis
- - The meta-analysis aimed to assess how effective Diagnosis-related group (DRG) payment systems are on improving inpatient care quality, specifically looking at factors like length of stay, readmission rates, and mortality through an extensive literature review.
- - The analysis included 29 studies with over 36 million patients and found that DRG payment significantly reduced the length of hospital stay, but it didn't have a notable impact on readmissions or mortality rates.
- - Although DRG payment was proven better than cost-based payment in reducing length of stay, the authors noted the need for more robust studies due to limitations in the existing research.
Multisystem ALK-positive histiocytosis: a multi-case study and literature review.
Orphanet J Rare Dis
March 2023
Article Synopsis
- Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a rare histiocytic disease first identified in infants, but cases in older children and adults have been recognized, though much about it remains unclear.
- Four cases of multisystem ALK-positive histiocytosis without blood involvement were documented, including adult patients showing varying responses to ALK inhibitors, and a young child with a severe case who did not respond well to treatment.
- The study highlights the need for further research on treatment options and prognosis, noting that adults may respond better to ALK inhibitors than young children with central nervous system issues.
Article Synopsis
- - The study examined the effects of a new patient classification-based payment system (DIP) implemented in 2018 in southeast China on healthcare costs and care quality for hospitalized patients.
- - Results showed that costs per case significantly increased for older adults, while the length of stay decreased for younger groups but increased for the oldest-old patients.
- - Overall, while costs rose for older patients, the quality of care remained stable, with no significant increase in in-hospital mortality rates across all age groups.
Article Synopsis
- A prospective study involving 351 patients from January 2017 to September 2020 aimed to assess the Prostate Health Index (phi) in predicting Gleason score upgrades from prostate biopsies to radical prostatectomies (RP) in a Chinese cohort.
- Phi and its derivative, phi density (PHID), were found to be significantly associated with upgrading Gleason scores in clinically low-risk patients, particularly those with low biopsy Gleason Grades (GG ≤2).
- The inclusion of phi and PHID improved predictive accuracy for score upgrades, as demonstrated by higher area under the curve (AUC) values when compared to the base model.
Background: Cryptosporidium viatorum is a minor Cryptosporidium pathogen in humans. Currently, there is limited information regarding the prevalence and genotypes of C. viatorum in animals in China.
View Article and Find Full Text PDF[Construction and operation of schistosomiasis diagnosis reference (network) laboratory in Yunnan Province].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
July 2019
Article Synopsis
- * The network involved quality-control assessments and evaluations of innovative diagnostic techniques and reagents for effective disease detection.
- * The paper discusses the review and operational challenges of the network laboratory, highlighting its importance for improving schistosomiasis control efforts in Yunnan Province.
Article Synopsis
- Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL-N) is an aggressive cancer diagnosed through small biopsies, but flow cytometry could improve its detection and classification.
- A study on 26 ENKTL-N biopsy samples identified seven key flow cytometry characteristics to differentiate cancerous cells from reactive NK-cells.
- The findings suggest that flow cytometry is a valuable tool for routine diagnosis, confirming cancer types, and tailoring treatments for patients with ENKTL-N.
[TCP wear particles causes injury of periprosthetic osteocytes in the mouse calvaria].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
January 2018
Article Synopsis
- The study investigates the effects of tricalcium phosphate (TCP) wear particles on osteocyte injuries in mouse calvaria and explores the underlying molecular mechanisms.
- Male mice were divided into three groups: a sham group, a TCP model group, and a 3-methyladenine (3-MA) group, with the latter receiving an autophagy inhibitor after TCP particle implantation.
- Results showed that TCP particles resulted in decreased osteocyte viability and increased apoptosis, while the 3-MA treatment exacerbated these injuries, indicating that TCP-induced osteocyte damage is linked to altered autophagy and specific protein expressions.
Article Synopsis
- Reproductive capacity in both animals and women decreases with age, with ovarian aging being a key factor, but the effects of uterine aging are still not fully understood.
- A study comparing pregnancy rates and uterine hormone responsiveness in ovariectomized mice revealed a notable decline in implantation and pregnancy rates as the mice aged from 2 months to 12 months.
- The research found significant hormonal changes in the older mice, indicating that altered steroid hormone responsiveness might play a role in reduced pregnancy success in aged subjects.
Embryo implantation and decidualization are key steps for successful reproduction. Although numerous factors have been identified to be involved in embryo implantation and decidualization, the mechanisms underlying these processes are still unclear. Based on our preliminary data, Prss56, a trypsin-like serine protease, is strongly expressed at implantation site in mouse uterus.
View Article and Find Full Text PDFArticle Synopsis
- * Lox is produced around the implanting blastocyst starting on day 5 of pregnancy and reaches peak levels in decidual cells between days 6 to 8, regulated by estrogen through a specific signaling pathway.
- * Inhibition of Lox activity leads to reduced expression of a related protein (Dtprp) and negatively impacts processes such as cell migration and embryo attachment, highlighting Lox's important role in pregnancy maintenance.
Endoplasmic reticulum stress in mouse decidua during early pregnancy.
Mol Cell Endocrinol
October 2016
Article Synopsis
- Accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, which plays a significant role in mammalian reproduction, particularly during the process of decidualization.
- The study reveals that the Ire-Xbp1 signaling pathway related to the unfolded protein response (UPR) is activated in decidual cells, and inhibiting this pathway disrupts the decidualization process both in living organisms and laboratory conditions.
- Results indicate that while high levels of ER stress induce DNA damage and inhibit stromal cell proliferation, lower levels may have beneficial effects, highlighting the complex role of ER stress signaling in mouse decidualization.
Article Synopsis
- - Aggressive natural killer cell leukemia (ANKL) is a rare and highly aggressive cancer with unclear causes, often misdiagnosed due to the low number of leukemia cells present in blood and bone marrow.
- - A study of 35 cases aimed to improve diagnostic methods and identify genetic or epigenetic factors linked to ANKL; findings included a predominance of young males and an unexpectedly aggressive clinical course.
- - The research found associations between better outcomes and factors like low lactate dehydrogenase levels and treatment with chemotherapy, while detecting specific mutations in STAT5B and hypermethylation of the HACE1 gene that may play a role in ANKL development.
Article Synopsis
- Endoscopic minimal invasive cholecystolithotomy (EMIC) is gaining popularity in China as a potentially better alternative to laparoscopic cholecystectomy (LC) for treating cholecystolithiasis.
- A review of 14 randomized controlled trials with 2030 patients found that EMIC resulted in less blood loss, shorter recovery times, and fewer complications compared to LC.
- Overall, EMIC patients experienced faster recovery and a lower complication rate, positioning it as a superior option to traditional laparoscopic methods.
Primary small cell neuroendocrine carcinoma of the tonsil: a case report and review of the literature.
Int J Clin Exp Pathol
February 2015
Article Synopsis
- Small cell neuroendocrine carcinoma (NEC) in the tonsil is very rare and associated with a poor prognosis, with limited treatment guidelines available.
- A 74-year-old woman presented with throat pain and was diagnosed via CT scan, biopsy, and immunohistochemical staining which confirmed the NEC in her left tonsil.
- After undergoing six cycles of chemotherapy, the patient initially responded well, but experienced a recurrence in the neck after 9 months and opted for no further treatment; the paper reviews this case and related literature on the tumor's characteristics and management.
Chemoresistance to cisplatin is a major limitation of cisplatin-based chemotherapy in the clinic. The combination of cisplatin with other agents has been recognized as a promising strategy to overcome cisplatin resistance. Previous studies have shown that wogonin (5,7-dihydroxy-8-methoxyflavone), a flavonoid isolated from the root of the medicinal herb Scutellaria baicalensis Georgi, sensitizes cancer cells to chemotheraputics such as etoposide, adriamycin, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TNF.
View Article and Find Full Text PDFArticle Synopsis
- Activating CD40 can lead to tumor growth inhibition or cell death, highlighting its potential as a target for cancer therapies.
- The study shows that CD40 activation enhances cisplatin-induced apoptosis through the induction of TNF-α, an important signaling molecule in cancer response.
- Blocking TNF-α significantly reduced the effectiveness of CD40's ability to sensitize cancer cells to cisplatin, indicating that TNF-α plays a crucial role in improving chemotherapy outcomes.