Near-Infrared Light-Responsive CuMoS@GelMA Hydrogel with Photothermal Therapy, Antibacterial Effect and Bone Immunomodulation for Accelerating Infection Elimination and Fracture Healing.

Managing fracture infections is a significant challenge in trauma orthopedics, given the limited self-healing capacity of fractures and the difficulty in eradicating infections. In this study, CuMoS nanoparticles (CMSs) with are prepared enzyme-like activity and both pH and near-infrared (NIR) light responsiveness. These CMSs are combined with methacrylated gelatin (GelMA) to synthesize CMSs hydrogels (CMSs@Gel) with antimicrobial and bone tissue repair-promoting capabilities.

Self-Trapped Excitons in 3R ZnInS with Broken Inversion Symmetry for High-Performance Photodetection.

Exploring novel materials with intrinsic self-trapped excitons (STEs) is crucial for advancing optoelectronic technologies. In this study, 2D 3R-phase ZnInS, featuring broken inversion symmetry is introduced to investigate intrinsic STEs. This material exhibits a broadband photoluminescence (PL) emission with a full width at half maximum of 164 nm and a large Stokes shift of ≈0.

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity.

Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, the role of ER autophagy (ER-phagy) in viral replication process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection results from the degradation of ER-phagy receptor FAM134B, facilitated by viral NS2A protein.

Large-scale metagenomic assembly provide new insights into the genetic evolution of gut microbiomes in plateau ungulates.

Trillions of microbes colonize the ungulate gastrointestinal tract, playing a pivotal role in enhancing host nutrient utilization by breaking down cellulose and hemicellulose present in plants. Here, through large-scale metagenomic assembly, we established a catalog of 131,416 metagenome-assembled genomes (MAGs) and 11,175 high-quality species-level genome bins (SGBs) from 17 species of ungulates in China. Our study revealed the convergent evolution of high relative abundances of carbohydrate-active enzymes (CAZymes) in the gut microbiomes of plateau-dwelling ungulates.

Cellulose nanocrystals (CNCs) with different degrees of amination to enhance tolerance to Fe (III) and enhance oil displacement performance.

Cellulose nanocrystals (CNCs) have been widely concerned in enhanced oil recovery (EOR) due to their abundant resources, small size and easy modification. In crude oil extraction, Fe (III) is increasingly produced. However, CNCs are very sensitive to Fe (III) and easy to aggregate, which brings obstacles to the application of CNCs.

Exploring the Impact of Physiological C-Terminal Truncation on α-Synuclein Conformations to Unveil Mechanisms Regulating Pathological Aggregation.

Emerging evidence suggests that physiological C-terminal truncation of α-synuclein (αS) plays a critical role in regulating liquid-liquid phase separation and promoting amyloid aggregation, processes implicated in neurodegenerative diseases such as Parkinson's disease (PD). However, the molecular mechanisms through which C-terminal truncation influences αS conformation and modulates its aggregation remain poorly understood. In this study, we investigated the impact of C-terminal truncation on αS conformational dynamics by comparing full-length αS with truncated αS monomers using atomistic discrete molecular dynamics simulations.

The relationship between keratin 18 and epithelial-derived tumors: as a diagnostic marker, prognostic marker, and its role in tumorigenesis.

As a structural protein, keratin is mainly expressed in epithelial cells and skin appendages to provide mechanical support and external resistance. The keratin family has a total of 54 members, which are divided into type I and type II. Two types of keratins connect to each other to form keratin intermediate filaments and participate in the construction of the cytoskeleton.

A Comparison Of Mosquito Species Assemblages Sampled With Three Commonly Used Traps And A Novel Design.

In nuisance or vector mosquito management, effective sampling is a stepping stone to efficient use of resources, targeted control efforts, and successful reduction of disease transmission. Experimental evidence indicates that there are species biases for certain traps, which in turn implies that the traps used will influence the species make-up of samples collected. A comparative study between 3 CO2-baited light traps and 2 hay-infusion baited gravid traps-Centers for Disease Control and Prevention (CDC) light trap, American BioPhysics Company (ABC) light trap, Reiter-Cummings (RC) gravid trap, and a convertible gravid/light trap with a novel design-was conducted to test for species specificity of each trap type.

Regulatory mechanisms of strigolactone perception in rice.

Strigolactones (SLs) are hormones essential for plant development and environmental responses. SL perception requires the formation of the complex composed of an SL receptor DWARF14 (D14), F-box protein D3, and transcriptional repressor D53, triggering ubiquitination and degradation of D53 to activate signal transduction. However, mechanisms of SL perception and their influence on plant architecture and environmental responses remain elusive and controversial.

Chest CT features and risk factors for patients with Omicron variant pneumonia: a multicenter retrospective clinical study.

Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron variant infection has become widespread in China as a result of the alterations in epidemic control and prevention policies. We identified the clinical characteristics and lung computed tomography (CT) imaging characteristics of patients infected during the early stage of the Omicron BA.5 wave in Shanghai to provide a guide to the diagnosis, treatment, and prognosis of infection.

A unique near-infrared fluorescent probe based on dual-DNP binding sites for rapid monitoring of hydrogen sulfide in food samples and living cells.

A new NIR fluorescent probe (DCIQ-2DNP), which combined the thiolysis of dinitrophenyl (DNP) ether and DNP-marked electron-deficient quaternary carbon, was reported for the first time for detection of HS. The DCIQ-2DNP probe showed an NIR emission signal (740 nm), a large Stokes shift (128 nm), and rapid monitoring of hydrogen sulfide (within 60 s) in food samples and living cells.

Efficacy, safety, and biomarker analysis of TACE combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a real-world study.

Background: The integration of transarterial chemoembolization (TACE) with systemic therapy has demonstrated improved survival outcomes in patients with unresectable hepatocellular carcinoma (HCC). However, there is limited evidence evaluating the combination of TACE with the systemic regimen of anti-PD-1/L1 inhibitor plus lenvatinib. This study aims to assess the efficacy and safety of TACE combined with lenvatinib and sintilimab in unresectable HCC patients.

Epstein-Barr virus positive post-transplant lymphoproliferative disorder with significantly decreased T-cell chimerism early after transplantation: A case report.

Background: Post-transplant lymphoproliferative disorder (PTLD) is a rare but highly fatal complication occurring after allogeneic hematopoietic cell transplantation (allo-HCT) or solid organ transplantation (SOT). Unlike SOT, PTLD after allo-HCT usually originates from the donor and is rarely accompanied by a loss of donor chimerism.

Case Summary: We report a case of Epstein-Barr virus positive PTLD manifesting as diffuse large B-cell lymphoma (DLBCL) with significantly decreased T-cell chimerism early after allo-HCT.

Integrative indexes reveal the tolerance of winter wheat to different overwinter freezing injury.

Winter wheat ( L.) is a crucial crop that guarantees food supply in the North China Plain (NCP). As the frequency of extreme cold events increases, it is necessary to explore the freezing resistance of different wheat varieties in order to clarify planting boundaries and help with risk assessment.

Cloning, bioinformatics analysis and expression of the cysteine dioxygenase type 1 (CDO1) gene in domestic yak.

Introduction: The CDO1 gene is an important gene in the taurine synthesis pathway and has been observed to have high expression in ovaries of female mammals. This study aims to explore the conservation of CDO1 gene in domestic yaks, as well as to examine the fundamental characteristics of CDO1 gene and its expression in female yaks.

Methods: Ovarian samples were collected from yaks in the follicular phase, luteal phase and gestation period in this experiment, and their total RNA and protein were extracted.

Relationship between hemoglobin glycation index and risk of hypoglycemia in type 2 diabetes with time-in-range in target.

Background: In patients with type 2 diabetes mellitus (T2DM), the risk of hypoglycemia also occurs in at a time-in-range (TIR) of > 70%. The hemoglobin glycation index (HGI) is considered the best single factor for predicting hypoglycemia, and offers new perspectives for the individualized treatment of patients with well-controlled blood glucose levels that are easily ignored in clinical settings.

Aim: To investigate the relationship between HGI and hypoglycemia and the implications of HGI on hypoglycemia in T2DM with TIR > 70%.

The effect of educational level on the recurrence rate and number of episodes of stroke in stroke survivors.

Objectives: This study aimed to assess the influence of educational level on the recurrence rate and number of stroke episodes in stroke survivors.

Materials And Methods: For this cross-sectional study, information regarding patient characteristics, medical history, ability to perform activities of daily living, level of disability, number of episodes, and stroke recurrence was collected. Analyses were conducted using the chi-square test, analysis of variance, nonparametric test, Cox regression model, and the Kaplan-Meier method.

A dual-mode strategy for early detection of sugarcane pokkah boeng disease pathogen: A portable sensing device based on Cross-N DNA framework and MoS@GDY.

Sucrose, a common sugar primarily derived from sugarcane, is a crucial national strategic resource. However, its yield is significantly affected by various serious diseases, with pokkah boeng disease being one of the most damaging. Therefore, developing a sensitive method for the accurate detection of the pokkah boeng disease pathogen is crucial for ensuring the safety of sugar.

Prevalence and associated risk factors of prostate cancer among a large Chinese population.

Prostate cancer (PCa) is one of the most important health problems among elderly men in China, with the increasing aging of the population. A cross-sectional survey was conducted in eastern China from 2022 to 2023. Recruitment included a total of 70,342 participants aged 60 or older.