Publications by authors named "Yan Hui Chen"
Aim: To access the agreement of intraocular pressure (IOP) values obtained from biomechanically corrected tonometer [Corvis ST (CST)], non-contact tonometer (NCT), and Goldmann applanation tonometer (GAT) in children with NCT measured-IOP (NCT-IOP) values of 22 mm Hg or more, and related factors.
Methods: A total of 51 eyes with NCT-IOP≥22 mm Hg in children aged 7 to 14y were examined and IOP was measured by CST, NCT, and GAT. Based on GAT measured IOP (GAT-IOP), ocular hypertension (OHT) group (≥22 mm Hg, 24 eyes) and the non-OHT group (<22 mm Hg, 27 eyes) were defined.
Room temperature low threshold lasing of green GaN-based vertical cavity surface emitting laser (VCSEL) was demonstrated under continuous wave (CW) operation. By using self-formed InGaN quantum dots (QDs) as the active region, the VCSEL emitting at 524.0 nm has a threshold current density of 51.
View Article and Find Full Text PDFObjective: Bone metabolism can be influenced by a range of factors. We selected children with self-limited epilepsy with centrotemporal spikes (SeLECTS) and lifestyles similar to those of healthy children to control for the confounding factors that may influence bone metabolism. We aimed to identify the specific effects of epilepsy and/or anti-seizure medications (ASMs) on bone metabolism.
View Article and Find Full Text PDFFlexible Silica/MXene/Natural rubber film strain sensors with island chain structure for Healthcare monitoring.
J Colloid Interface Sci
November 2023
The demand for flexible strain sensors with high sensitivity and durability has increased significantly. However, traditional sensors are limited in terms of their detection ranges and fabrications. In this work, a space stacking method was proposed to fabricate natural rubber (NR)/ TiCT (MXene)/silica (SiO) films that possessed exceptional electrical conductivity, sensitivity and reliability.
View Article and Find Full Text PDFPurpose: The SCAF4 gene encodes serine/arginine-related carboxyl-terminal domain-associated factor 4, which is highly expressed in the brain and potentially affects neurodevelopment. However, the functional significance of SCAF4 variants in human diseases remains unknown.
Methods: Trio-based whole-exome sequencing was performed in three individuals with focal epilepsy.
Article Synopsis
- - Mitochondrial diseases (MDs) are complex disorders caused by issues in both mitochondrial and nuclear DNA, and a study was conducted using dual genomic sequencing to improve diagnosis in pediatric patients.
- - In a review of 503 pediatric patients, causative genetic variants were found in 177 (35.2%), with a notable fraction (9.1%) having variants directly related to mitochondria.
- - Dual genomic sequencing proved effective for identifying mitochondrial disorders, but notably, some patients with mitochondrial-related variants were still misclassified as unlikely to have such disorders, highlighting the need for careful evaluation.
Gosling plague caused by goose parvovirus (GPV), a highly infectious septic disease with high mortality, has caused substantial loss in the waterfowl industry. A method for the rapid detection of GPV is needed. In this study, we isolated the virus strain of GPV in May 2020 and applied it to the loop-mediated isothermal amplification (LAMP) assay.
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- Researchers demonstrated dual-wavelength switchable emission in InGaN quantum dot micro-cavity light-emitting diodes (MCLEDs) that can toggle between outputs at 498.5 nm and 541.7 nm by adjusting the injected current levels.
- The microcavity effect allows for high spectral purity with a narrow linewidth of 0.21 nm, enabling deterministic mode switching in the green spectrum.
- The study highlights design and fabrication techniques for controlled dual-wavelength operation, which can be utilized in applications like multi-wavelength optical recording and optical switches.
Article Synopsis
- The study examines how COVID-19 affected hospital admissions and the types of diseases among children at a South China hospital from January 2019 to January 2021.
- A total of 2139 patient records were reviewed, revealing a 29.6% drop in hospitalisations during the pandemic, mainly in infection-related and respiratory diseases, while musculoskeletal disorders became more common.
- The findings suggest that although fewer children were admitted, those who were tended to stay longer in the hospital, indicating shifts in disease patterns due to the pandemic.
Article Synopsis
- A study assessed 3,573 freshman students at Tianjin Medical University over four years to determine the prevalence of refractive errors, finding an alarming rise in myopia from 93.5% in 2017 to 96.2% in 2020.
- High myopia rates reached 28.6%, with males exhibiting higher levels of astigmatism, mostly classified as "with-the-rule."
- Ocular measurements indicated significant differences between genders, with females generally having shorter eye lengths and distinct biometrical characteristics compared to males; overall, high myopia was linked to longer axial lengths.
Article Synopsis
- Macrophages play a crucial role in the immune response within the tumor microenvironment, but their specific impact on non-small cell lung cancer (NSCLC) prognosis remains unclear.
- A study analyzed samples from 681 NSCLC patients using advanced staining techniques to categorize macrophages and their relationship with other immune markers, utilizing machine learning to develop a risk score for predicting disease-free survival.
- Results showed that higher levels of macrophages, particularly M1 types, were linked to shorter disease-free survival; a newly created immune-related risk score (IRRS) demonstrated good predictive accuracy for cancer recurrence compared to traditional single markers.
Background: Ullrich congenital muscular dystrophy (UCMD) is one of the collagen-VI-related myopathies caused by mutations of , , and genes. Affected individuals are characterized by muscle weakness, proximal joint contracture, distal joint hyperlaxity, and progressive respiratory failure. There is currently no cure for UCMD.
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- Ni-rich layered oxides, like NCM811, are promising cathode materials for batteries due to their high energy density, but they suffer from capacity loss and structural changes during use.
- Researchers doped high-valence transition metals (V, Nb, and Zr) into the Ni site of NCM811 to enhance its electrochemical performance through computational simulations.
- The study found that V doping, in particular, reduces Ni oxidation, minimizes oxygen loss, improves lithium migration, and diminishes lattice distortion, making V the best candidate for boosting the stability and capacity of NCM811.
The unc-13 homolog B (UNC13B) gene encodes a presynaptic protein, mammalian uncoordinated 13-2 (Munc13-2), which is highly expressed in the brain-predominantly in the cerebral cortex-and plays an essential role in synaptic vesicle priming and fusion, potentially affecting neuronal excitability. However, the functional significance of the UNC13B mutation in human disease is not known. In this study, we screened for novel genetic variants in a cohort of 446 unrelated cases (families) with partial epilepsy without acquired causes by trio-based whole-exome sequencing.
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- * Diagnosing OAG in patients with high myopia is difficult due to complications like optic disc tilt and extensive tissue atrophy.
- * Advances in imaging technologies, particularly optical coherence tomography (OCT) and OCT angiography (OCTA), show potential for better detection of highly myopic OAG, leading to new diagnostic and treatment approaches.
Article Synopsis
- * A study of 41 patients in Nanchang, China, between February and March 2020 revealed that most had close contact with confirmed cases and exhibited common symptoms like fever and cough, with a median age of 39.9 years.
- * All patients recovered, but findings indicated high levels of certain cytokines and other abnormal laboratory results, suggesting the need for monitoring these biochemical markers in patients with mild symptoms.
Tailoring Au Films at the Atomic Scale with an Electron Beam Tweezer.
J Nanosci Nanotechnol
December 2020
Article Synopsis
- - A thin, pure gold film was created inside a transmission electron microscope using an electron beam to design specific nanopatterns.
- - Different doses of the electron beam were used to produce various shapes like hexagonal holes and dumbbell patterns.
- - High-quality images were taken to study how the electron beam manipulates atoms through collisions, essentially enabling it to act like a tweezer for precise arrangement.
Article Synopsis
- PJP has become a significant issue in HIV-negative patients, particularly due to increased use of immunosuppressants, with a study involving 96 hospitalized patients in Southern China.
- The majority of cases were found in middle-aged men, with kidney and connective tissue diseases being major risk factors; most patients had recent low-dose immunosuppressive treatments and none had prophylaxis with TMP-SMX.
- Clinical symptoms often included cough, dyspnea, fever, and chest pain, with over 90% showing elevated levels in key biochemical tests, suggesting the need for better early diagnosis and treatment strategies to enhance survival rates.
Rice grains are a methylmercury (MeHg) intake route for humans, especially in certain mercury (Hg)-contaminated areas. For rice plant growth, animal manure is commonly used as an organic fertilizer; however, its role in the formation of MeHg in paddy soils remains poorly understood. The aims of this study were thus to explore 1) the effect of chicken manure (CH) and cow manure (CO) addition on the production of soil MeHg and the accumulation of MeHg in rice plants and 2) the mechanism by which CH and CO addition affect the bioaccumulation of MeHg in grains.
View Article and Find Full Text PDFEfficacy of resveratrol for the treatment in patients with ulcerative colitis: Study Protocol.
Medicine (Baltimore)
November 2019
Background: This study will aim to systematically explore the efficacy of resveratrol for the treatment of patients with ulcerative colitis (UC).
Methods: We will search the electronic databases of MEDLINE, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure up to the September 1, 2019 for randomized controlled trials (RCTs) that report on UC who have undergone resveratrol compared with other interventions. All electronic databases will be searched without restrictions of language.
Rationale: Bacteremia caused by polymicrobial infections are rare but dangerous. We report a case of hepatic abscess combined with polymicrobial bacteremia in a 49-year-old male patient after surgery and transcatheter arterial chemoembolization (TACE).
Patient Concerns: The patient was admitted to hospital with metastatic liver cancer for periodic chemotherapy and developed a high fever and tenderness to the liver following surgery and TACE.
[Effects of ketogenic diet on lipid metabolism in children with intractable epilepsy].
Zhongguo Dang Dai Er Ke Za Zhi
May 2019
Article Synopsis
- The study looked at how a ketogenic diet (KD) affects fat levels in kids with hard-to-treat epilepsy.
- Researchers checked the blood of 47 kids before and after 3 months on the diet to see changes in fat levels like cholesterol.
- Results showed that while some fat levels changed, the increase in one type (LDL) might mean kids on this diet could have a higher risk of heart problems in the future.
Article Synopsis
- Researchers successfully created tough and strong blends of polypropylene random co-polymer (PPR) and styrene-ethylene-butylene-styrene (SBS) by incorporating multi-wall carbon nanotubes (MWCNTs) and β-nucleating agents (β-NAs).
- The β-NAs help form a beneficial β-crystal structure in the PPR, enhancing its toughness, while the MWCNTs improve tensile strength.
- When both MWCNTs and β-NAs were used together, the impact strength of the PPR/SBS blend increased dramatically from 11.3 to 58.9 kJ/m², showing significant improvements in toughness without sacrificing much tensile strength.
An analysis of the Cd and mineral nutrients accumulation of upland rice was performed in an experimental field with hard-ridged plots containing three soils with exogenous Cd addition at rates of 0, 0.25, 0.5, 1, 2, 4, 8, 16 mg kg five years prior to commence this experiment.
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