Multidisciplinary approach improves eradication rate and safety in refractory Helicobacter pylori infection: Multidisciplinary approach for H. pylori.

Introduction: Helicobacter pylori (HP) infection is prevalent worldwide and contributes to various gastrointestinal diseases. Eradication therapy is crucial in managing HP infection, but antibiotic resistance has led to refractory cases, complicating treatment outcomes and increasing the risk of adverse events.

Objectives: This study aimed to evaluate the effectiveness of a multidisciplinary approach, termed HP Multidisciplinary Team (MDT) Clinic, in improving eradication rates and safety in patients with refractory HP infection.

Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer.

Background: Gastric cancer (GC) has a high mortality rate, and robust diagnostic biomarkers are currently lacking. However, the clinical relevance of circular RNAs (circRNAs) as GC biomarkers remains largely unexplored.

Aim: To evaluate the potential of novel circRNA circ_0004592 in the early screening and prognosis of GC.

Intracellular TMEM16A is necessary for myogenesis of skeletal muscle.

Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules. In myoblasts, TMEM16A was primarily localized to the cytosolic compartment and partially co-localized with intracellular organelles.

Combining serum peptide signatures with International Federation of Gynecology and Obstetrics (FIGO) risk score to predict the outcomes of patients with gestational trophoblastic neoplasia (GTN) after first-line chemotherapy.

Background: Gestational trophoblastic neoplasia (GTN) is a group of clinically rare tumors that develop in the uterus from placental tissue. Currently, its satisfactory curability derives from the timely and accurately classification and refined management for patients. This study aimed to discover biomarkers that could predict the outcomes of GTN patients after first-line chemotherapy.

The Effect of Kangaroo Mother Care After Duodenal Obstruction in Neonates.

Objective: The present study aimed to explore the effectiveness of clinical application of kangaroo mother care (KMC) in neonates after surgery for duodenal obstruction in achieving total enteral nutrition (TEN) and shortening the length of hospital stay.

Methods: A prospective study of 60 cases of surgery for duodenal obstruction in pediatric patients in the neonatal intensive care unit of Kunming Children's Hospital between January 2018 and December 2019 was conducted. The study subjects included 15 cases with intestinal malrotation, 18 cases with circular pancreas, 10 cases with a duodenal septum, and 17 cases with duodenal atresia or duodenal stenosis.

Curative effect evaluation by using Andrews' six elements for completed orthodontic treatment cases.

Objectives: To assess the treatment outcome of patients who completed their orthodontic treatment by using Andrews' six elements and the American Board of Orthodontic (ABO) objective grading system (OGS); to determine whether Andrews' six elements can be used as a new assessment system for patients who completed their orthodontic treatment.

Methods: A total of 160 patients who completed their orthodontic treatment were included in the study. The participants were randomly selected from patients who completed their orthodontic procedures in Kunming Medical University Affiliated Stomatological Hospital during the period of 2015 to 2019.

The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis.

The radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (ASMase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in BALB/c mice by immunostaining of biomarkers for cell division (Ki67), immature neurons (doublecortin or DCX), and interneurons (parvalbumin or PV) in the dentate gyrus (DG) of hippocampus. The results indicated that preirradiation (with 10 mg/kg, 2 times per day, for 7 consecutive days) or postirradiation (with 10 mg/kg, 2 times per day, for 14 consecutive days) treatment (pretreatment or posttreatment) with intraperitoneal injection of amitriptyline prevented the loss of newly generated neurons, proliferating cells, and interneurons in the subgranular zone of the DG. At the molecular level, pretreatment or posttreatment inhibited the expression of sphingomyelin phosphodiesterase 1 () gene which codes for ASMase.

MicroRNA-139-3p Inhibits The Growth And Metastasis Of Ovarian Cancer By Inhibiting ELAVL1.

Background: The aberrant expression of microRNA-139-3p (miR-139-3p) has been recently involved in the development of multiple tumor types, but its function in ovarian cancer remains not well investigated. In this study, we mainly investigated the function of miR-139-3p in the progression of ovarian cancer.

Methods: The levels of miR-139-3p in ovarian cancer cells and tissues were detected using quantitative real-time-PCR (qRT-PCR) assay.

Structure elucidation and antimicrobial activities of five compounds from Artemisia integrifolia L.

A new compound, integracid (1), together with four known compounds were isolated from the dichloromethane (CH2Cl2) extract from Artemisia integrifolia L. The structures of compounds (1-5) were elucidated by spectroscopic methods, including ultraviolet, infrared (IR), high resolution-electrospray ionization-mass spectrometry (HR-ESI-MS) and extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) techniques, and by comparison with data reported in the references. Antibacterial activities of the compounds were evaluated against various bacteria.

Systems Chemical Genetics-Based Drug Discovery: Prioritizing Agents Targeting Multiple/Reliable Disease-Associated Genes as Drug Candidates.

Genetic disease genes are considered a promising source of drug targets. Most diseases are caused by more than one pathogenic factor; thus, it is reasonable to consider that chemical agents targeting multiple disease genes are more likely to have desired activities. This is supported by a comprehensive analysis on the relationships between agent activity/druggability and target genetic characteristics.

Expression of programmed death ligand-1 and programmed death 1 in hepatocellular carcinoma and its clinical significance.

Objective: To investigate the correlation between the expression of programmed death 1 (PD-1) and PD ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) and clinical parameters.

Materials And Methods: The study comprised tumor sections from 45 HCC patients treated with curative resection, which were evaluated for PD-1 and PD-L1 protein expression by immunohistochemistry.

Results: PD-1 and PD-L1 expression was increased in cancers compared to adjacent normal tissues, with a positive rate of 37.

The prevalence and sex difference of allergen sensitization among adult patients with allergic diseases in Shanghai, China.

Background: The worldwide prevalence of allergic diseases has increased during the last few decades, but it is not well known about the sensitization profiles of adult patients in Shanghai.

Objective: This study aimed to identify the prevalence and sex difference of allergen sensitization among adult with allergic diseases in Shanghai.

Methods: The sensitization profiles of 7,996 patients (18-60 yrs old) with allergic diseases at our center were retrospectively analyzed, based on the results of skin prick tests.

[Fate of Eleven Phthalic Acid Esters in Aerobic Sewage Treatment System].

Phthalic acid esters have potential environmental risk due to their endocrine disrupting effect. The biodegradable and removal characteristics of 11 phthalicacidesters were studied. The results showed that dimethyl phthalate(DMP), dimethoxyethyl phthalate (BMEP), diethyl phthalate(DEP), dibutyl phthalate (DBP), diisobutyl phthalate(DIBP), dinamyl phthalate (DNPP), di--hexyl phthalate(DNHP)and bis (2-ethylhexyl) phthalate (DEHP) had ready biodegradability, dinonyl phthalate (DNP)and dicyclohexyl phthalate (DHP)could be biodegraded but did not pass the 10 d window-period, and only 43.

[Performance of Polymer-based Titanium and Zirconium Oxides Composite Adsorbent for Simultaneous Removal of Phosphorus and Fluorine from Water].

A novel composite adsorbent (Ti-Zr-D201) for simultaneous removal of phosphate and fluoride from water was prepared by loading nanosized titanium and zirconium oxides on the anion exchange resin named D201. Combining with the characterization of the adsorbent, adsorption isotherm experiments, effect of solution pH experiments, competitive tests, kinetic experiments and fixed bed column adsorption experiments were performed to explore the adsorption performance and mechanism. The maximum adsorption capacity of Ti-Zr-D201 for phosphorus and fluorine was 34.

[Degradation Characteristics of Three Aniline Compounds in Simulated Aerobic Sewage Treat System].

The removal rates of 4-nitroaniline, 4-isopropyl aniline and 2-chloro-4-nitroaniline under different hydraulic retention time (HRT) were tested by employing a simulation method of aerobic biochemical sewage treatment technology in this study. The results showed that when HRT was 6 h, 12 h, and 24 h, the removal rates of dissolved organic carbon (DOC) were 70.2%, 80.

[Development of Chemical Exposure Prediction Model for Aerobic Sewage Treatment Plant for Biochemical Wastewaters].

Sewage treatment plant (STP) is a key transfer station for chemicals distributed into different environment compartment, and hence models of exposure prediction play a crucial role in the environmental risk assessment and pollution prevention of chemicals. A mass balance model namely Chinese Sewage treatment plant (C-STP(O)) was developed to predict the fate and exposure of chemicals in a conventional sewage treatment plant. The model was expressed as 9 mixed boxes by compartment of air, water, suspended solids, and settled solids.

Randomized study of gefitinib versus pemetrexed as maintenance treatment in patients with advanced glandular non-small cell lung cancer.

Gefitinib was compared with pemetrexed as maintenance therapy in Patients with Advanced Glandular Non-small Cell Lung Cancer, mainly regarding clinical effect and side effect. A randomized trial of pemetrexed as study group (500 mg/m(2), dl) versus gefitinib as the control group [250 mg on night 1, 250 mg on morning 2 (every day)] was conducted in 188 patients, 94 cases in each group with a therapy cycle of 21 days. In addition, the study group was also treated with folic acid, vitB12 and dexamethasone.

Indicators of child health, service utilization and mortality in Zhejiang Province of China, 1998-2011.

Objective: To investigate the levels of primary health care services for children and their changes in Zhejiang Province, China from 1998 to 2011.

Methods: The data were drawn from Zhejiang maternal and child health statistics collected under the supervision of the Health Bureau of Zhejiang Province. Primary health care coverage, hospital deliveries, low birth weight, postnatal visits, breastfeeding, underweight, early neonatal (<7 days) mortality, neonatal mortality, infant mortality and under-5 mortality were investigated.

Under 5 mortality rate and its contributors in Zhejiang Province of China from 2000 to 2009.

Objective: By analyzing the under 5 mortality rate (U5MR) and its contributors in Zhejiang Province of China from 2000 to 2009, we tried to understand the trend of U5MR change in Zhejiang Province and thus propose strategies to reduce child mortality.

Methods: Thirty cities/counties/districts from Zhejiang Province were selected using stratified cluster sampling approach. Children under five years in these areas were enrolled as the subjects.

[Antitumor activity of histone deacetylase inhibitor suberic bishydroxamate on acute myeloid leukemia cell lines].

Objective: To investigate the effect of histone deacetylase inhibitor suberic bishydroxamate (SBHA) on human acute myeloid leukemia (AML) cell lines.

Methods: AML U937, KG-1 and Kasumi-1 cells were treated with SBHA. Cell growth was measured by MTT assay.

[The under-five mortality rate and the causes of death in Zhejiang Province between 2000 and 2009].

Objective: To study the under-five mortality rate and the causes of death in Zhejiang Province between 2000 and 2009 in order to provide a basis for reducing the mortality rate in the region.

Methods: By stratified random cluster sampling, all the children under 5 years old from 30 sampling areas of Zhejiang Province between 2000 and 2009 were enrolled. The under-five mortality rate and the leading causes of death were investigated by descriptive analysis and Chi-square test.