Three-step versus "see-and-treat" approach in women with high-grade squamous intraepithelial lesions in a low-resource country.

Objective: To investigate the frequency of cervical intraepithelial neoplasia (CIN) 2 or greater in women with high-grade squamous intraepithelial lesion (HSIL), and to evaluate whether colposcopically-directed biopsy is a necessary procedure for managing HSIL in a low-resource country.

Methods: A retrospective review was undertaken of women with HSIL on a Pap smear.

Results: Of 348 women who had undergone colposcopically-directed biopsies and loop electrosurgical excisional procedure (LEEP), 321 (92.

[Combining high-risk human papillomavirus DNA test and cytological test to detect early cervical dysplasia].

Objective: To assess the value of combining high-risk human papillomavirus (HPV) DNA test and cytological test in detection of early cervical dysplasia.

Methods: During January 2003 to June 2004, a total of 5210 women were screened by combining high-risk HPV DNA test (hybrid capture II, HC-II) and cytological test (liquid-based ThinPrep cytology test), and the abnormal cytological or HPV DNA findings were further biopsied under the colposcope.

Results: The age of the patients was between 17 to 80, the average was 34 +/- 9.