Clinical-grade human dental pulp stem cells improve adult hippocampal neural regeneration and cognitive deficits in Alzheimer's disease.

Disrupted hippocampal functions and progressive neuronal loss represent significant challenges in the treatment of Alzheimer's disease (AD). How to achieve the improvement of pathological progression and effective neural regeneration to ameliorate the intracerebral dysfunctional environment and cognitive impairment is the goal of the current AD therapy. We examined the therapeutic potential of clinical-grade human derived dental pulp stem cells (hDPSCs) in cognitive function and neuropathology in AD.

Multi-Granularity Temporal Embedding Transformer Network for Traffic Flow Forecasting.

Traffic flow forecasting is integral to transportation to avoid traffic accidents and congestion. Due to the heterogeneous and nonlinear nature of the data, traffic flow prediction is facing challenges. Existing models only utilize plain historical data for prediction.

A MACPF Protein OsCAD1 Balances Plant Growth and Immunity Through Regulating Salicylic Acid Homeostasis in Rice.

Unraveling the mechanisms behind plant growth and immunity contributes to effective crop improvement. Membrane attack complex/perforin (MACPF) domain proteins play vital roles in innate and adaptive immunity in vertebrates; however, their molecular functions in plants remain largely unexplored. Here, we isolated and characterized a rice mutant, Oryza sativa constitutively activated cell death 1 (oscad1), which exhibited a lesion mimic phenotype and growth inhibition with increased cell death, elevated ROS accumulation, and enhanced resistance to bacterial blight Xanthomonas oryzae pv.

Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding.

Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment (EVT). Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB.

Natural variation in ZmNRT2.5 modulates husk leaf width and promotes seed protein content in maize.

The husk leaf of maize (Zea mays) encases the ear as a modified leaf and plays pivotal roles in protecting the ear from pathogen infection, translocating nutrition for grains and warranting grain yield. However, the natural genetic basis for variation in husk leaf width remains largely unexplored. Here, we performed a genome-wide association study for maize husk leaf width and identified a 3-bp InDel (insertion/deletion) in the coding region of the nitrate transporter gene ZmNRT2.

Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study.

Background: The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk of suffering from dyslipidaemia.

Research Design And Methods: This cross-sectional study included 1036 inpatients with T2DM and the clinical data were extracted from the hospital medical records.

Factors That Influence Young Adults' Preferences for Virtual Reality Exergames in a Weight Control Setting: Qualitative Study.

Background: Obesity could compromise people's health and elevate the risk of numerous severe chronic conditions and premature mortality. Young adults are at high risk of adopting unhealthy lifestyles related to overweight and obesity, as they are at a phase marked by several significant life milestones that have been linked to weight gain. They gain weight rapidly and excess adiposity mostly accrues, compared with middle-aged and older adults when weight stabilizes or even decreases.

Tea consumption and cognitive health in Chinese older adults: A propensity score matching and weighting analysis.

Background: The association between tea consumption, especially different types, and cognitive function has not been adequately explored. This study aimed to investigate the associations of tea consumption, including status, frequency, and type, with cognitive function, considering selection bias.

Methods: We used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2018(N = 8498).

Amorphous-dominated MgO hollow spheres enhanced fluoride adsorption: Mechanism analysis and machine learning prediction.

Amorphous-dominated magnesium oxide hollow spheres (A-MgO) were prepared using a spray-drying method in this study. These hollow spheres exhibited excellent sphericity, large specific surface areas, and abundant porosity. A-MgO exhibited outstanding fluoride adsorption properties, with a maximum adsorption capacity of 260.

AKR1B10 and digestive tumors development: a review.

Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases.

Tellurium nanoparticles and Fucoidan-loaded dissolvable microneedles for combined photothermal therapy and anti-angiogenesis in melanoma treatment.

Melanoma, an aggressive skin tumor, is prone to metastasis, significantly reducing patient survival rates once it occurs. Tumor microvascularity is a key factor in metastasis, making the inhibition of microvascular formation crucial. Emerging photothermal therapy (PTT) and microneedles (MNs) have garnered attention due to their non-invasive and controllable nature.

GLP-1 and IL-6 regulates obesity in the gut and brain.

Obesity is a chronic metabolic disease characterized by excessive nutrient intake leading to increased subcutaneous or visceral fat, resulting in pathological and physiological changes. The incidence rate of obesity, an important form of metabolic syndrome, is increasing worldwide. Excess appetite is a key pathogenesis of obesity, and the inflammatory response induced by obesity has received increasing attention.

Visible-Light-Induced Synthesis of Azlactone Monomers and Dimers utilizing SF as both Condensation Agent and Oxidant.

The visible-light-mediated continuous dehydration condensation and oxidative radical dimerization, featuring sulfur hexafluoride (SF) as both a condensation agent and oxidant, have been developed. This photocatalytic method uses commercially available N-protected amino acids as substrates and enables the formation of azlactone monomers and dimers, facilitating efficient utilization and degradation of greenhouse gas SF.

[Carbon Emission Analysis and Carbon Reduction Strategy of Small and Medium-scale Municipal Wastewater Treatment Plants in Cities and Towns].

The carbon emissions of three typical processes （AAO, MSBR, and oxidation ditch） were systematically analyzed from the perspective of the whole wastewater treatment process based on the annual data of eleven urban small and medium-scale WWTPs in the year 2022, and the effects of different influent characteristics （TP, TN, BOD, COD, influent volume, and COD/TN） on the carbon emissions were studied by using the partial least squares structural equation modeling （PLS-SEM） method. The results showed that indirect carbon emissions dominated the total carbon emissions of small and medium-scale WWTPs （69.5%）, and carbon emissions from electricity consumption were the largest source （43.

The value of metagenomic next-generation sequencing with blood samples for the diagnosis of disseminated tuberculosis.

Objective: The aim of this study was to assess the clinical value of metagenomic next-generation sequencing (mNGS) of blood samples for the identification of disseminated tuberculosis (DTB).

Methods: A total of 48 individuals suspected of DTB were enrolled. All patients underwent mNGS of peripheral blood and conventional microbiological tests.

Fabrication of Polydopamine-Coated High-Entropy MXene Nanosheets for Targeted Photothermal Anticancer Therapy.

Transition metal carbides, nitrides, and carbonitrides (MXenes) have emerged as a promising class of 2D materials that can be used for various applications. Recently, a new form of high-entropy MXenes has been reported, which contains an increased number of elemental species that can increase the configurational entropy and reduce the Gibbs free energy. The unique structure and composition lead to a range of intriguing and tunable characteristics.

Study on identification of diagnostic biomarkers in serum for papillary thyroid cancer in different iodine nutrition regions.

Background: At present, there is a lack of efficient biomarkers for the diagnosis of thyroid cancer, and the influence of natural factors such as high iodine exposure on the expression of biomarkers remains unclear.

Methods: Serum samples from papillary thyroid cancer (PTC) and non-cancer controls matched 1:1 in different iodine nutritional regions were analyzed metabolomically using an ultra-high performance liquid chromatography-Orbitrap Exploris mass spectrometry (UHPLC-OE-MS) platform. Then the data were randomly divided into training and test sets in a 1:1 ratio according to the different iodine nutritional regions and different PTC status.

[Pharmacokinetic differences and related mechanisms of ginkgo flavone aglycone in normal and atherosclerotic rats in vivo].

This study aimed to compare the pharmacokinetics of ginkgo flavone aglycone(GA) in plasma after oral administration of GA in normal and atherosclerosis(AS) model rats and to explore the mechanism of pharmacokinetic differences. The AS rats were prepared by using high-fat diets. Rats in the normal and AS model groups were orally given 200 mg·kg~(-1) GA, blood samples were collected at different time points, plasma was separated, and the plasma concentrations of quercetin, kaempferol and isorhamnetin in the normal and AS model groups were determined by ultra-performance liquid chromatography-mass spectrometry(UPLC-MS/MS).

Therapeutic applications of stem cell-derived exosomes in radiation-induced lung injury.

Radiation-induced lung injury is a common complication of chest tumor radiotherapy; however, effective clinical treatments are still lacking. Stem cell-derived exosomes, which contain various signaling molecules such as proteins, lipids, and miRNAs, not only retain the tissue repair and reconstruction properties of stem cells but also offer improved stability and safety. This presents significant potential for treating radiation-induced lung injury.

Maternal group B decreases infant length and alters the early-life microbiome: a prospective cohort study.

Background: Maternal colonization with Group B Streptococcus (GBS) disrupts the vaginal microbiota, potentially affecting infant microbiota assembly and growth. While the gut microbiota's importance in infant growth is recognized, the specific effects of maternal GBS on growth remain unclear. This study aimed to explore the effects of maternal vaginal GBS during pregnancy on early infant growth, microbiome, and metabolomics.

Development and Validation of the Resident Healthcare-Seeking Culture Scale (RHCS) Among Chinese Demographics in the Community Setting.

Objective: This study aimed to develop a measurement scale with good reliability and validity to assess the reasonableness of resident healthcare-seeking culture.

Methods: This investigation utilized a cross-sectional research design, employing a multi-stage random sampling technique to select adult inhabitants aged eighteen and above who possess fundamental literacy abilities. An online survey was conducted from March to April 2021 across 27 provinces in China, encompassing 911 questionnaires for scale development.

Time-of-day control of mitochondria regulates NLRP3 inflammasome activation in macrophages.

Macrophages are innate immune cells that orchestrate the process of inflammation, which varies across time of day. This ensures appropriate biological timing of the immune response with the external environment. The NLRP3 inflammasome mediates IL-1-family cytokine release via pyroptosis.