Publications by authors named "Yan Haijian"
Activating adult neural stem cells (NSCs) located within the spinal cord niche is considered a promising therapeutic approach for treating spinal cord injury (SCI). Cerebrospinal fluid (CSF)-contacting neurons expressing Pkd2l1 exhibit phenotypic and molecular traits similar to those of adult NSCs. However, the mechanism responsible for regulating the activation of Pkd2l1 CSF-cNs still needs to be discovered.
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- Multiple sclerosis (MS) is an autoimmune disease with no cure, and the protein S100A4 plays a role in regulating inflammation related to MS, although its exact mechanisms are unclear.
- Research involved manipulating S100A4 levels in mouse-derived microglia cells and studying its effects in an animal model of MS (EAE), revealing that mice with reduced S100A4 showed milder disease symptoms and less inflammation.
- Findings indicate that S100A4 could influence neuroinflammation by affecting microglial inflammation and cell death pathways, suggesting it may be a potential target for MS treatment.
Objective: Data about postoperative infections in male adults with spinal cord injury are scarce. We aimed to evaluate the association between prior exposure to pressure ulcers (PU) and the risk of postoperative infections in male adults with spinal cord injury (SCI).
Methods: We conducted a prospective study of male adults receiving surgery of SCI from January 2007 to December 2019.
Background: Fcγ receptors (FcγR) play substantial immune regulatory roles both positively and negatively in pathophysiological processes including allergy and asthma. Compared with FcγRIIB which is classically defined as an inhibitory receptor, mouse FcγRIIIA and its functional human homologue FcγRIIA have been assumed to be activating receptors. However, evidence demonstrating inhibitory regulation by mouse FcγRIIIA has recently been emerging.
View Article and Find Full Text PDFBombyx mori nucleopolyhedrovirus (BmNPV) is one of the most acute infectious diseases in silkworm, which has led to great economic loss in sericulture. Previous study showed that the content of secondary metabolites in mulberry leaves, particularly for moracin N, was increased after UV-B irradiation. In this study, the BmNPV resistance of silkworms reared on UV-B treated and moracin N spread mulberry leaves was improved.
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