Altered gut microbial profiles in drug-treated rats with alcoholic heart disease.

Alcohol abuse can lead to significant cardiac injury, resulting in Alcoholic heart disease (AHD). The interplay between cardiac health and gut microbiota composition in the context of alcohol consumption is not well understood. Shen Song Yang Xin (SSYX) capsule and amiodarone are common drugs used to treat alcoholic heart disease, but little is known about their microbial regulatory mechanisms in alcoholic heart disease.

An optimized public opinion communication system in social media networks based on K-means cluster analysis.

This study proposes a public opinion monitoring model that combines the K-means clustering algorithm with Particle Swarm Optimization (PSO) to enhance the accuracy and effectiveness of public opinion monitoring on social media. The model's performance across various dissemination indicators is studied in detail. Through experiments conducted on social media datasets, the study comprehensively evaluates the model from four dimensions: dissemination speed, scope, depth, and sentiment dissemination effectiveness.

Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study.

Objective: The purpose of this study is to analyze the predictive value of neutrophil to lymphocyte ratio (NLR), lymphocyte count to monocyte count ratio (LMR), platelet to lymphocyte ratio (PLR), platelet count multiplied by neutrophil count to lymphocyte count ratio (SII), red blood cell distribution width (RDW), packed cell volume (PCV), and plateletcrit (PCT) levels in advanced non-small cell lung cancer (NSCLC) patients treated with PD-1/PD-L1 inhibitors.

Materials And Methods: From March 2019 to August 2023, we screened 104 of 153 patients with stage III unresectable local advanced NSCLC and IV NSCLC who received PD-1/PD-L1 inhibitor therapy at our hospital and met the inclusion and exclusion criteria for analysis. All patients were collected for clinical information, including baseline blood indicator (NLR, PLR, LMR, SII, CRP, RDW, PCV and PCT) levels before PD-1/PD-L1 inhibitor therapy and blood indicator levels and imaging evaluation results every two cycles after PD-1/PD-L1 inhibitor therapy.

N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma.

The balance between CD8 T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) plays a crucial role in the immune checkpoint inhibition (ICI) therapy in gastric carcinoma (GC). However, related factors leading to the disturbance of TME and resistance to ICI therapy remain unknown. In this study, we applied N6-methyladenosine (m6A) small RNA Epitranscriptomic Microarray and screened out 3'tRF-AlaAGC based on its highest differential expression level and lowest inter-group variance.

[Quantitative Analysis of the Drivers of the Spatio-temporal Evolution of Vegetation NPP in the Beijing-Tianjin-Hebei Ecological Barrier Area].

The Taihangshan-Yanshan Region is an important ecological barrier area in Beijing-Tianjin-Hebei, and it is of great importance to investigate the spatial distribution pattern and driving mechanism of net primary productivity （NPP） of vegetation for ecological restoration. The MOD17A3HGF.061 NPP dataset was obtained using the Google earth engine（GEE）, and Sen trend, coefficient of variation, partial correlation, complex correlation, and residual analysis were applied to investigate the spatial and temporal patterns of vegetation NPP in the study area and to quantitatively isolate the relative contributions of climate change and human activities.

Different Role of PET-CT Evaluation in Newly Diagnosed Follicular Lymphoma Upon Rituximab-Based Chemotherapy and Chemo-Free Immunotherapy.

Newly diagnosed follicular lymphoma (FL) patients usually received first-line rituximab-based immunochemotherapy (R-chemo). Recently, rituximab plus lenalidomide (R2) emerged as an alternative chemo-free immunotherapy. We performed a comparative analysis of positron emission tomography/computed tomography (PET/CT) in FL undergoing R-chemo or R2.

Compression force promotes the osteogenic differentiation of periodontal ligament stem cells by regulating NAT10-mediated ac4C modification of BMP2.

Background: Orthodontic treatment applies specific corrective forces to teeth, transmitting stress to periodontal tissue, thereby regulating the growth and development of periodontal ligament stem cells (PDLSCs). Recently, N-acetyltransferase 10 (NAT10) mediated N4-acetylcytidine (ac4C) modification is demonstrated to play a key role in the osteogenic differentiation of stem cells. Therefore, this study aimed explore the effects of Orthodontic treatment on the NAT10 mediated ac4C modification and osteogenic differentiation of PDLSCs.

Simultaneous removal of Microcystis aeruginosa and microplastics by oxidation enhanced coagulation.

The composite pollution is an increasingly severe challenge in the field of water treatment. Especially, microplastics (MPs) contamination and Microcystis aeruginosa (M. aeruginosa) were verified that they could synergistically pose a serious threat to safety of drinking water.

SARS-CoV-2 seroprevalence and antibody trajectories after easing of COVID-19 restrictions: a longitudinal study in China.

Background: We aimed to evaluate the seroprevalence of SARS-CoV-2 and investigate the trajectories of protective immunity and associated risk factors in eastern China between March and November 2023 after the easing of COVID-19 restrictions.

Materials And Methods: We conducted repeated population-based seroepidemiologic studies using a multistage, population-stratified, cluster random sampling method. We measured neutralizing antibodies (nAbs) using a fluorescence immunoassay.

Memantine-Assisted Treatment of N-Methyl-D-Aspartate Receptor Antibody Encephalitis: A Mini Review.

N-methyl-D-aspartate receptor encephalitis (NMDARE) presents serious neurological manifestations such as reduced consciousness, seizures, and movement disorders, which can escalate to coma or severe autonomic dysfunction. Treatment typically involves immunotherapy and tumor removal to mitigate the autoimmune response. Timely diagnosis and treatment are critical to prevent severe neurological impairment or death.

Study on the Macro-/Micrometric Characteristics and Mechanical Properties of Clayey Sandy Dredged Fill in the Guangdong Area.

The study of dredged fill in Guangdong (GD), China, is of great significance for reclamation projects. Currently, there are relatively few studies on dredged fill in Guangdong, and there are many differences in the engineering characteristics of dredged fill foundations formed through land reclamation and natural foundations. In order to have a more comprehensive understanding of the physico-mechanical properties of blowing fill in the coastal area of GD and to understand the effect of its long-term creep row on the long-term settlement and deformation of buildings, the material properties, microstructure, elemental composition, triaxial shear properties, and triaxial creep properties of dredged fill in Guangdong were studied and analyzed through indoor geotechnical tests, scanning electron microscopy (SEM), X-ray diffraction (XRD), and conventional triaxial shear tests and triaxial creep tests.

Low Evaporation Enthalpy Ionic Covalent Organic Frameworks for Efficient Atmospheric Water Harvesting at Low Humidity.

Herein, we introduce a series of ionic covalent organic frameworks (iCOFs) with a focus on addressing the challenge of water collection at low relative humidity levels below 25 %. These iCOFs are characterized by numerous hydrophilic sites and high water stability, enabling efficient water vapor adsorption even at relatively low humidity levels. Through the use of various hygroscopic salt cations and precise control of ion concentration within the pores, the water state within the iCOFs pores can be effectively managed.

Size-Coded Hydrogel Microbeads for Extraction-Free Serum Multi-miRNAs Quantifications with Machine-Learning-Aided Lung Cancer Subtypes Classification.

Classifying lung cancer subtypes, which are characterized by multi-microRNAs (miRNAs) upregulation, is important for therapy and prognosis evaluation. Liquid biopsy is a promising approach, but the pretreatment of RNA extraction is labor-intensive and impairs accuracy. Here we develop size-coded hydrogel microbeads for extraction-free quantification of miR-21, miR-205, and miR-375 directly from serum.

A highly stable gellan gum/potato starch/anthocyanin smart film with ferulic acid co-pigmentation for monitoring fish freshness.

A novel high stability pH-sensitive smart film (GGPS-R-FA) was prepared by using gellan gum (GG) and potato starch (PS) as the film-forming material, red cabbage anthocyanins extract (RCAE) as the indicator, and ferulic acid (FA) as the co-pigmentation agent. The enhancement effect of co-pigmentation on the stability of RCAE, as well as the performance and application of smart film were investigated. The RCAE co-pigmented with FA showed higher absorbance and greater thermal stability, as evidenced by the retention of anthocyanin content and thermodynamic parameters.

Simultaneous removal of cyanobacteria and algal organic matter by Mn(VII)/CaSO enhanced coagulation: Performance and mechanism.

Frequent outbreaks of algal blooms greatly threatened drinking water safety, garnering widespread attention. Mn/CaSO is emerging in the field of organic matter removal with its efficient oxidizing capacity and wide pH application range. The performance of Mn(VII)/CaSO as a pre-oxidation process enhancing coagulation for algae removal (Microcystis aeruginosa, 2 (±0.

Enhanced beneficial lipids and volatile compounds in Jersey ghee attributed by key microbiota.

Ghee, a traditional fermented dairy product and dietary staple for inhabitants of the Tibet Plateau, has unclear lipid profiles and flavor formation mechanisms. This study aims to characterize superior ghee varieties and elucidate factors driving the production of beneficial lipids and flavor compounds. Through a comprehensive analysis of lipidomic profiles, volatile organic compound (VOC) release and microbial dynamics during ghee production from Holstein milk (HM) and Jersey milk (JM), A total of 126 differential lipids were identified, primarily associated with glycerophospholipid and sphingolipid metabolism.

Weakly Solvating Electrolytes for Safe and Fast-Charging Sodium Metal Batteries.

Electrolytes for high-performance sodium metal batteries (SMBs) are expected to have high electrode compatibility, low solvation energy, and nonflammability. However, conventional flammable carbonate ester electrolytes show high Na desolvation energy and poor compatibility with sodium metal anodes, leading to slow Faradaic reactions and significant degradation of SMBs. Herein, we report a weakly solvating electrolytes (WSEs) design developed by an ionized ether-induced solvent molecule polarization strategy.

Regulated Li Solvation via Competitive Coordination Mechanism of Organic Cations for High Voltage and Fast Charging Lithium Metal Batteries.

Li solvation exerted a decisive effect on electrolyte physicochemical properties. Suitable tuning for Li solvation enabled batteries to achieve unexpected performance. Here, we introduced inert organic cations to compete with Li for combining electrolyte molecules to modulate Li coordination in the electrolyte.

Wearable Resistive-Type Stretchable Strain Sensors: Materials and Applications.

The rapid advancement of wearable electronics over recent decades has led to the development of stretchable strain sensors, which are essential for accurately detecting and monitoring mechanical deformations. These sensors have widespread applications, including movement detection, structural health monitoring, and human-machine interfaces. Resistive-type sensors have gained significant attention due to their simple design, ease of fabrication, and adaptability to different materials.

Intestinal microbiota-mediated serum pharmacochemistry reveals hepatoprotective metabolites of Platycodonis Radix against APAP-induced liver injury.

The urgent need for new medications that regulate CYP2E1, CASP3, Nrf2, HO-1, TLR2, TLR4, STAT3, and NF-κB activities is paramount for the treatment of drug-induced liver injury (DILI), particularly from acetaminophen (APAP). Previous studies have suggested that platycosides of Platycodonis Radix exhibits hepatoprotective properties against APAP-induced liver injury (AILI), and their serum metabolites may be the effective agents. As the identify the serum metabolites of platycosides is a huge challenge, the mechanism whether platycosides exert effects through the serum metabolites regulating those targets still remain unclear.

Electronic interactions between SnO crystals and porous N-doped carbon nanoflowers accelerate electrochemical reduction of CO to formate.

The electrochemical carbon dioxide reduction reaction (CORR) to formic acid or formate is a highly effective approach for achieving carbon neutrality. However, multiple proton-coupling-electronic processes and the instability of the catalysts caused by surface poisoning greatly limit the overall efficiency of CORR to formate. Here, a facile method was developed to anchor ∼2.

Improvement effect of insulin resistance in one-day outpatient service by reducing stress adaptation disorders in patients with gestational diabetes mellitus.

Aim: Conducted a one-day outpatient service for GDM patients, analyzed the relationship between stress adaptation disorder and insulin resistance in GDM patients after intervention, and tried to provide some new clues for the prevention and treatment of GDM, provide some theoretical basis for the multidisciplinary diagnosis and treatment model of GDM patients.

Methods: 240 GDM women were included in this study, 120 women were included in one-day diabetes clinic management for GDM women as GDM Intervention Group, and 120 GDM women receiving regular dietary education as GDM Control Group. One-day diabetes clinic management including disease knowledge and dietary education, sports education and blood sugar monitoring and personalized issues and follow-up visits, and intervention time lasting for 1 month.