Selective corticocortical connectivity suppression during propofol-induced anesthesia in healthy volunteers.

Unlabelled: We comprehensively studied directional feedback and feedforward connectivity to explore potential connectivity changes that underlie propofol-induced deep sedation. We further investigated the corticocortical connectivity patterns within and between hemispheres. Sixty-channel electroencephalographic data were collected from 19 healthy volunteers in a resting wakefulness state and propofol-induced deep unconsciousness state defined by a bispectral index value of 40.

The expression and methylation of genes is associated with the prognosis of head and neck squamous cell carcinoma.

The gene family, comprising , , and , is critical in organogenesis and has been evolutionary conserved in animals. genes are associated with the advanced progression and poor prognosis of multiple cancers. However, the relationship between the genes and head and neck squamous cell carcinoma (HNSC) has not been reported.

A robust defect detection method for syringe scale without positive samples.

With the worldwide spread of the COVID-19 pandemic, the demand for medical syringes has increased dramatically. Scale defect, one of the most common defects on syringes, has become a major barrier to boosting syringe production. Existing methods for scale defect detection suffer from large volumes of data requirements and the inability to handle diverse and uncertain defects.

Association between physical activity and mild cognitive impairment in community-dwelling older adults: Depression as a mediator.

Introduction: Dementia has become a public health priority and is irreversible. Mild cognitive impairment (MCI), an intermediate state between normal cognition and dementia, is the prime time for early diagnosis and intervention. The activities of daily living of dementia patients are usually insufficient.

Remote control of the recruitment and capture of endogenous stem cells by ultrasound for in situ repair of bone defects.

Stem cell-based tissue engineering has provided a promising platform for repairing of bone defects. However, the use of exogenous bone marrow mesenchymal stem cells (BMSCs) still faces many challenges such as limited sources and potential risks. It is important to develop new approach to effectively recruit endogenous BMSCs and capture them for in situ bone regeneration.

Molecular Imaging of Steroid-Induced Osteonecrosis of the Femoral Head through iRGD-Targeted Microbubbles.

Osteonecrosis of the femoral head (ONFH) is a disease that is commonly seen in the clinic, but its detection rate remains limited, especially at the early stage. We developed an ultrasound molecular imaging (UMI) approach for early diagnosis of ONFH by detecting the expression of integrin αvβ3 during the pathological changes in steroid-induced osteonecrosis of the femoral head (SIONFH) in rat models. The integrin αvβ3-targeted PLGA or lipid microbubbles modified with iRGD peptides were fabricated and characterized.

Bimodal Imaging of Tumors via Genetically Engineered .

Although there are emerging innovations of molecular imaging probes to detect and image tumors, most of these molecular dyes and nanoparticles have limitations of low targetability in tumors and fast clearance when administered systemically. In contrast, some bacteria, such as , can selectively proliferate in a hypoxic environment inside of a tumor for several days, which highlights the potential for the development of a genetically encoded multimodal imaging probe to monitor the progress of the tumor. Here, we developed bimodal imaging tumor-homing bacteria (GVs-miRFP680 MG1655) that allow both optical and acoustic imaging in tumor-bearing mice.

Deep Sparse Autoencoder and Recursive Neural Network for EEG Emotion Recognition.

Recently, emotional electroencephalography (EEG) has been of great importance in brain-computer interfaces, and it is more urgent to realize automatic emotion recognition. The EEG signal has the disadvantages of being non-smooth, non-linear, stochastic, and susceptible to background noise. Additionally, EEG signal processing network models have the disadvantages of a large number of parameters and long training time.

ZEB1 regulates bone metabolism in osteoporotic rats through inducing POLDIP2 transcription.

Background: Osteoporosis (OP) is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the role of zinc finger E-box binding homeobox 1 (ZEB1) in OP.

Methods: First, gene expression microarrays for OP were downloaded from the Gene Expression Omnibus database and analyzed to screen for potential targets.

Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases.

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases. Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently open the BBB, providing a potential strategy for drug delivery across the BBB into the brain. Nowadays, taking advantage of this technology, many therapeutic agents, such as antibodies, growth factors, and nanomedicine formulations, are intensively investigated across the BBB into specific brain regions for the treatment of various brain diseases.

Silica nanochannels boosting Ru(bpy) -mediated electrochemical sensor for the detection of guanine in beer and pharmaceutical samples.

Vertically ordered mesoporous silica film (VMSF) with uniform mesoporous channels perpendicular to electrode substrate has a wide range of applications in direct electroanalysis of complex samples. However, the detection of nucleic acid bases is difficult to realize at the commonly used VMSF-modified indium tin oxide (VMSF/ITO) electrode due to the high overpotentials of underlying ITO for many small organic molecules. In this work, we demonstrated an electrochemical method for the sensitive detection of guanine (G) by integration of VMSF/ITO and tris(2,2'-bipyridine) ruthenium (II) [Ru(bpy) ] redox mediator.

BRAF p.V600E genetic testing based on ultrasound-guided fine-needle biopsy improves the malignancy rate in thyroid surgery: our single-center experience in the past 10 years.

Purpose: Ultrasound-guided fine-needle aspiration biopsy (UG-FNAB) was implemented in Qilu Hospital of Shandong University in 2015 as a preoperative diagnostic method for thyroid surgery. BRAF p.V600E genetic testing was implemented in 2019.

Deciphering Cellodextrin and Glucose Uptake in .

Sugar uptake is of great significance in industrially relevant microorganisms. Clostridium thermocellum has extensive potential in lignocellulose biorefineries as an environmentally prominent, thermophilic, cellulolytic bacterium. The bacterium employs five putative ATP-binding cassette transporters which purportedly take up cellulose hydrolysates.

Measuring the indirect cost associated with advanced non-small cell lung cancer: a nationwide cross-sectional study in China.

Purpose: This study was conducted to estimate the indirect cost of locally advanced and metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR and ALK alterations in China and explore the predictors from both patient and caregiver perspectives.

Methods: Data were obtained from a nationwide cross-sectional study for the patients with advanced NSCLC (stage IIIB-IV) and their caregivers. Indirect medical cost was estimated as health productivity loss based on self-reported income and loss of work time.

Cyclodextrin-Functionalized Gold Nanorods Loaded with Meclofenamic Acid for Improving -Methyladenosine-Mediated Second Near-Infrared Photothermal Immunotherapy.

Cancer immunotherapy has achieved considerable clinical progress in recent years on account of its potential to treat metastatic tumors and inhibit recurrence. However, low patient response rates and dose-limiting toxicity are the major limitations of immunotherapy. Nanoparticle-based photothermal immunotherapy can amplify antitumor immune responses, although poor tumor penetration depth of near-infrared radiation (NIR) and the immunosuppressive tumor microenvironment significantly dampen its effects.

The role of oxidative stress in ovarian aging: a review.

Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is considered to be a key factor. This review focuses on the fact that OS status accelerates the ovarian aging process by promoting apoptosis, inflammation, mitochondrial damage, telomere shortening and biomacromolecular damage.

A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy.

Adipose-derived stem cells (ADSCs) show potential in skin regeneration research. A previous study reported the failure of full-thickness skin self-repair in an injury area exceeding 4 cm in diameter. Stem cell therapies have shown promise in accelerating skin regeneration; however, the low survival rate of transplanted cells due to the lack of protection during and after transplantation leads to low efficacy.

The effectiveness of percutaneous endoscopic lumbar discectomy combined with external lumbar drainage in the treatment of intervertebral infections.

Objective: To analyze the effect of percutaneous endoscopic lumbar discectomy in treating lumbar intervertebral infections.

Methods: A total of 13 patients with lumbar intervertebral infections who underwent percutaneous endoscopic lumbar discectomy combined with external drainage between November 2016 and December 2019 were enrolled in the present study. After the operation, sensitive antibiotics were used based on the results of the bacterial culture.

Design of Convolutional Neural Network Processor Based on FPGA Resource Multiplexing Architecture.

As CNNs are widely used in fields such as image classification and target detection, the total number of parameters and computation of the models is gradually increasing. In addition, the requirements on hardware resources and power consumption for deploying CNNs are becoming higher and higher, leading to CNN models being restricted to certain specific platforms for miniaturization and practicality. Therefore, this paper proposes a convolutional-neural-network-processor design with an FPGA-based resource-multiplexing architecture, aiming to reduce the consumption of hardware resources and power consumption of CNNs.

miR-24-1/enhancer axis activation blocks renal cell carcinoma progression Warburg effect.

Warburg effect is a pivotal hallmark of cancers and appears prevalently in renal cell carcinoma (RCC). FBP1 plays a negative role in Warburg effect as a rate-limiting enzyme in gluconeogenesis, yet its mechanism in RCC remains to be further characterized. Herein, we revealed that was downregulated in RCC tissue samples and was related to the poor survival rate of RCC.

Metabolic-Dysregulation-Based iEESI-MS Reveals Potential Biomarkers Associated with Early-Stage and Progressive Colorectal Cancer.

The application of rapid and accurate diagnostic methods can improve colorectal cancer (CRC) survival rates dramatically. Here, we used a non-targeted metabolic analysis strategy based on internal extractive electrospray ionization mass spectrometry (iEESI-MS) to detect metabolite ions associated with the progression of CRC from 172 tissues (45 stage I/II CRC, 41 stage III/IV CRC, and 86 well-matched normal tissues). A support vector machine (SVM) model based on 10 differential metabolite ions for differentiating early-stage CRC from normal tissues was built with a good prediction accuracy of 92.

Construction of Hexagonal Prism-like Defective BiOCL Hierarchitecture for Photocatalytic Degradation of Tetracycline Hydrochloride.

Oxygen vacancy manipulation and hierarchical morphology construction in oxygen-containing semiconductors have been demonstrated to be effective strategies for developing high efficiency photocatalysts. In most studies of bismuth-based photocatalysts, hierarchical morphology and crystal defects are achieved separately, so the catalysts are not able to benefit from both features. Herein, using boiling ethylene glycol as the treatment solution, we developed an etching-recrystallization method for the fabrication of 3D hierarchical defective BiOCl at ambient pressure.

High-throughput fluorescent screening of β-lactamase inhibitors to improve antibiotic treatment strategies for tuberculosis.

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which is a major threat to global public health. Currently, β-lactam antibiotics are rarely used in the treatment of TB, since Mtb naturally expresses β-lactamase (Blac) which renders Mtb resistant to such antibiotics due to β-lactam cleavage. Fortunately, antibiotic resistance can be overcome when β-lactam antibiotics are combined with a Blac inhibitor.

Scalable Method for Eliminating Residual ZZ Interaction between Superconducting Qubits.

Unwanted ZZ interaction is a quantum-mechanical crosstalk phenomenon which correlates qubit dynamics and is ubiquitous in superconducting qubit systems. It adversely affects the quality of quantum operations and can be detrimental in scalable quantum information processing. Here we propose and experimentally demonstrate a practically extensible approach for complete cancellation of residual ZZ interaction between fixed-frequency transmon qubits, which are known for long coherence and simple control.