Morphology restrained growth of VO by the oxidation of V-MXenes as a fast diffusion controlled cathode material for aqueous zinc ion batteries.

Herein, we report morphology controlled growth of layered VO on VC by the oxidation of V-MXenes at different temperatures and used it as a cathode material for Zn-ion batteries (ZIBs). Hence, the VO nanoparticles are uniformly grown on the VC nanosheets with interlinked disordered carbon which provide fast diffusion and high rate performance in aqueous zinc-ion batteries.

The efficacy of spinal anaesthesia with fentanyl supplementation for arthroscopic knee surgery: A meta-analysis of randomized controlled studies.

Introduction: The efficacy of spinal anaesthesia with fentanyl supplementation for arthroscopic knee surgery remains controversial. We conducted a systematic review and meta-analysis to explore the influence of fentanyl supplementation for arthroscopic knee surgery.

Methods: We searched PubMed, Embase, Web of Science, EBSCO and Cochrane Library databases through May 2019 for randomized controlled trials (RCTs) assessing the efficacy and safety of fentanyl supplementation for arthroscopic knee surgery.

A high-throughput targeted metabolomics method for the quantification of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolism: application in the study of a CCl-induced liver injury mouse model.

Much evidence suggested that cholesterol, eicosanoid and phospholipid metabolism plays crucial roles in inflammation, atherosclerosis, carcinogenesis, etc. Therefore, fast and accurate quantification of the metabolites in these metabolic pathways is necessary for discovering the molecular mechanisms and biomarkers of related diseases. In this assay, ultra-high performance liquid chromatography combined with triple quadrupole mass spectrometry platform (UPLC-QqQ-MS) based protocols were developed to simultaneously quantify a total of 104 key metabolites including 32 phospholipids (PLs), 44 eicosanoids (EAs), 28 oxysterols and bile acids (BAs), within 15 minutes.

A Role for Mediator Core in Limiting Coactivator Recruitment in .

Mediator is an essential, multisubunit complex that functions as a transcriptional coactivator in yeast and other eukaryotic organisms. Mediator has four conserved modules, Head, Middle, Tail, and Kinase, and has been implicated in nearly all aspects of gene regulation. The Tail module has been shown to recruit the Mediator complex to the enhancer or upstream activating sequence (UAS) regions of genes via interactions with transcription factors, and the Kinase module facilitates the transition of Mediator from the UAS/enhancer to the preinitiation complex via protein phosphorylation.

Ochratoxin A and fumonisin B exhibit synergistic cytotoxic effects by inducing apoptosis on rat liver cells.

Aflatoxin G (AFG), ochratoxin A (OTA), fumonisin B (FB) and sterigmatocystin (ST) are very common toxic fungal metabolites with high detection rate and toxicity. The co-existence of many mycotoxins in animal feed has been reported worldwide, thus it is important to evaluate the combined cytotoxic effects among these mycotoxins. This study analysed the combined cytotoxic effects of the four mycotoxins in rat liver cells (BRL) and preliminary investigate their molecular mechanism.

Biomedical Research Cohort Membership Disclosure on Social Media.

To accelerate medical knowledge discovery, an increasing number of research programs are gathering and sharing data on a large number of participants. Due to the privacy concerns and legal restrictions on data sharing, these programs apply various strategies to mitigate privacy risk. However, the activities of participants and research program sponsors, particularly on social media, might reveal an individual's membership in a study, making it easier to recognize participants' records and uncover the information they have yet to disclose.

Responses of gaseous sulfuric acid and particulate sulfate to reduced SO concentration: A perspective from long-term measurements in Beijing.

SO concentration decreased rapidly in recent years in China due to the implementation of strict control policies by the government. Particulate sulfate (pSO) and gaseous HSO (SA) are two major products of SO and they play important roles in the haze formation and new particle formation (NPF), respectively. We examined the change in pSO and SA concentrations in response to reduced SO concentration using long-term measurement data in Beijing.

Effect of apatinib plus neoadjuvant chemotherapy followed by resection on pathologic response in patients with locally advanced gastric adenocarcinoma: A single-arm, open-label, phase II trial.

Background: The evidence of combining neoadjuvant chemotherapy with targeted therapy for patients with locally advanced gastric cancer is inadequate. We conducted a single-arm phase II trial to evaluate the efficacy and safety of S-1, oxaliplatin and apatinib (SOXA) in patients with locally advanced gastric adenocarcinoma.

Methods: Treatment-naïve patients received three preoperative cycles of S-1 (80-120 mg/day on days 1-14) and oxaliplatin (130 mg/m on day 1) and two cycles of apatinib (500 mg/day for 21 days) at 3-week intervals, followed by surgery.

Identification of alternatively spliced gene isoforms and novel noncoding RNAs by single-molecule long-read sequencing in .

Direct single-molecule sequencing of full-length transcripts allows efficient identification of gene isoforms, which is apt to alternative splicing (AS), polyadenylation, and long non-coding RNA analyses. However, the identification of gene isoforms and long non-coding RNAs with novel regulatory functions remains challenging, especially for species without a reference genome. Here, we present a comprehensive analysis of a combined long-read and short-read transcriptome sequencing in .

Rapid and accurate detection of Escherichia coli O157:H7 in beef using microfluidic wax-printed paper-based ELISA.

Escherichia coli O157:H7 is a severe foodborne pathogen that causes lots of life-threatening diseases. In the search for a rapid, sensitive, portable and low-cost method to detect this pathogen, we developed a wax-printed paper-based enzyme-linked immunosorbent assay (P-ELISA) based on microfluidic paper-based analytical devices (μPADs), with the whole operation time being less than 3 h and only needing 5 μl samples for detection. The limit of detection (LOD) of E.

Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder.

Purpose: Recent task-based fMRI studies have shown that Persistent Somatoform Pain Disorder (PSPD) patients demonstrated aberrant activity in a wide range of brain regions associated with sensation, cognition and emotion. However, these specific task-based studies could not clearly uncover the alterations in the spontaneous brain networks that were associated with the general pain-related symptoms in PSPD.

Patients And Methods: In the present study, 13 PSPD patients and 23 matched healthy controls (HCs) were enrolled.

Seroepidemiological Investigation of Crimean-Congo Hemorrhagic Fever Virus in Sheep and Camels of Inner Mongolia of China.

Crimean-Congo hemorrhagic fever (CCHF) is a highly lethal infectious disease in humans caused by tick-borne Crimean-Congo hemorrhagic fever virus (CCHFV). To determine the potential risk of CCHF in the pastoral area of Northwestern China, the presence of antibody to CCHFV in the sera of two most common tick hosts, sheep and camels, in Inner Mongolia of China was evaluated. The purified recombinant nucleocapsid protein (NP) of CCHFV was prepared from a prokaryotic vector expressing the NP encoding gene, which was employed as the antigen to probe antibody against CCHFV in tick vectors using an immunoblotting assay.

Changes in BMP-2 expression and mechanical properties during treatment of rats with osteoporotic hindlimb fracture with strontium ranelate.

Objectives: This study aims to investigate the changes in bone morphogenetic protein-2 (BMP-2) expression and mechanical properties in the healing process of rats with osteoporotic hindlimb fracture.

Methods: 120 rat models of osteoporotic hindlimb fracture were established and randomly divided into experimental group and control group. Quantitative real-time polymerase chain reaction (PCR) used to detect the BMP-2 expression in the rat's callus tissue on the fractured side.

Genomic Analysis of Putative Virulence Factors Affecting Cytotoxicity of .

spp. can cause systemic infections, such as meningitis, sepsis, and necrotizing enterocolitis, in immunocompromised patients, especially neonates. Although some virulence factors have been reported previously, the pathogenesis of remains unclear.

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis.

Background: Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown.

Development and validation of a new IgE-Tolerant ELISA method for quantifying serum concentration of omalizumab.

Background: Omalizumab is effectively used in asthma therapy, but ELISA methods used for omalizumab determination in blood from asthma patients may be interfered by the pre-existing IgE.

Objective: To reduce the effect of pre-existing IgE on the omalizumab determination, the authors proposed a novel ELISA that can eliminate pre-existing IgE with by acid dissociation.

Method: The method was developed by dissociating the IgE-omalizumab complex with glacial acetic acid, and bio-IgE was added to bind the free omalizumab in serum, then bio-IgE-complex was captured by the immobilized streptavidin and detected by HRP-conjugated mouse anti-human IgG.

Construction of three half-sib SSR linkage maps derived from overwintering cultivated rice and segregation distortion loci mapping.

Segregation distortion is a common phenomenon that has been observed in genetics and plant breeding; however, the mechanism of segregation distortion is unknown. In the present study, three half-sib F populations derived from three overwinter (perennial) rice varieties (W1, W2, and W3) crossed to the rice variety Minghui725 (MH725) were developed to construct three half-sib linkage maps. We established linkage map lengths of 2032.

Formation and growth of sub-3-nm aerosol particles in experimental chambers.

Atmospheric new particle formation (NPF), which is observed in many environments globally, is an important source of boundary-layer aerosol particles and cloud condensation nuclei, which affect both the climate and human health. To better understand the mechanisms behind NPF, chamber experiments can be used to simulate this phenomenon under well-controlled conditions. Recent advancements in instrumentation have made it possible to directly detect the first steps of NPF of molecular clusters (~1-2 nm in diameter) and to calculate quantities such as the formation and growth rates of these clusters.

Management of Schwannoma in the hepatoduodenal ligament: A case report and review of the literature.

Rationale: Schwannomas are neoplasms that originate from Schwann cells of the peripheral nerve sheath with a low malignant potential. Considering that Schwannomas often occur in the upper extremities, trunk, head, and neck, but in the hepatoduodenal ligament has seldom been reported.

Patient Concerns: A 70-year-old man was referred to our hospital for further evaluation of distension in upper abdomen.

Porous g-CN and MXene Dual-Confined FeOOH Quantum Dots for Superior Energy Storage in an Ionic Liquid.

Owing to their unique nanosize effect and surface effect, pseudocapacitive quantum dots (QDs) hold considerable potential for high-efficiency supercapacitors (SCs). However, their pseudocapacitive behavior is exploited in aqueous electrolytes with narrow potential windows, thereby leading to a low energy density of the SCs. Here, a film electrode based on dual-confined FeOOH QDs (FQDs) with superior pseudocapacitive behavior in a high-voltage ionic liquid (IL) electrolyte is put forward.

Use of a rapid recombinase-aided amplification assay for Mycoplasma pneumoniae detection.

Background: Mycoplasma pneumoniae is one of the most common causative pathogens of community-acquired pneumonia (CAP), accounting for as many as 30-50% of CAP during peak years. An early and rapid diagnostic method is key for guiding clinicians in their choice of antibiotics.

Methods: The recombinase-aided amplification (RAA) assay is a recently developed, rapid detection method that has been used for the detection of several pathogens.

Anchoring MnCoO Nanorods from Bimetal-Organic Framework on rGO for High-Performance Oxygen Evolution and Reduction Reaction.

Oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are important reactions of energy storage and conversion devices. Therefore, it is highly desirable to design efficient and dual electrocatalysts for replacing the traditional noble-metal-based catalysts. Herein, we have developed a high-efficiency and low-cost MnCoO-rGO nanocomposite derived from bimetal-organic frameworks.

A study on soybean responses to drought stress and rehydration.

To investigate soybean responses to drought stress and growth through metabolism compensation after rehydration, and for the establishment of an optimal water-saving irrigation model, we used the soybean variety Suinong 14 as experimental material and adopted a weighing method for water control in potted plants. We exposed soybean plants to stress treatments at different growth stages using different stress levels and durations. We then studied the effects of drought stress and rehydration on soybean growth and development, osmoregulation, and endogenous hormonal regulations, as well as antioxidant systems.