Publications by authors named "Yan'an Ren"
Article Synopsis
- Improper use of antibiotics is creating "superbugs" that resist treatment, outpacing new antibiotic discovery.
- A new screening method using a nanoliter matrix SlipChip (nm-SlipChip) allows for rapid testing of potential antibiotics, reducing sample consumption significantly.
- This method successfully identified two novel compounds from the plant Callicarpa integerrima that can combat MRSA, highlighting its potential in tackling antibiotic resistance.
Antimicrobial resistance (AMR) has become an increasingly severe threat to global health, and AMR-associated infection is one of the leading causes of death around the world. Due to the long turnaround time and the limited flexibility and availability of current antimicrobial susceptibility testing (AST) methods, a large portion of patients with bacterial infections are still treated empirically, increasing the risk of mistreatment. To address the demand for precision treatment of bacterial infections, we developed a nano-dilution SlipChip (nd-SlipChip)-based systematic evaluation method, which facilitates rapid, logic feedback for the assessment of antibiotics, antibiotic combinations, and phage therapy.
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