Publications by authors named "Yamir Reina-Doreste"
Myxomatous mitral valve disease (MMVD) is a prevalent canine cardiac disease typically diagnosed and classified using echocardiography. However, accessibility to this technique can be limited in first-opinion clinics. This study aimed to determine if machine learning techniques can classify MMVD according to the ACVIM classification (B1, B2, C, and D) through a structured anamnesis, quality of life survey, and physical examination.
View Article and Find Full Text PDFBackground: The diagnosis of congestive heart failure (CHF) in cats is challenging. Point-of-care (POC) thoracic ultrasound and NT-proBNP testing are emerging tools that may aid in diagnosis.
Hypothesis/objectives: To assess the diagnostic accuracy of POC lung ultrasound (LUS), focused cardiac ultrasound (FCU), and NT-proBNP in predicting a final diagnosis of CHF.
Objectives: Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is particularly common in the Cavalier King Charles Spaniel (CKCS) breed and affected dogs are frequently managed with angiotensin-converting enzyme inhibitors (ACE-I). We have previously identified a canine ACE gene polymorphism associated with a decrease in angiotensin-converting enzyme (ACE) activity.
View Article and Find Full Text PDFObjective: The objective of this study was to evaluate angiotensin-converting enzyme (ACE) activity in dogs and with and without an ACE polymorphism in the canine ACE gene, before and after treatment with an ACE inhibitor.
Methods: Thirty-one dogs (20 wild-type, 11 ACE polymorphism) with heart disease were evaluated with ACE activity measurement and systolic blood pressure before and after administration of an ACE inhibitor (enalapril).
Results: Median pre-treatment ACE activity was significantly lower for ACE polymorphism dogs than for dogs with the wild-type sequence ( P=0.
Objective: β-Adrenergic receptor antagonists are widely utilized for the management of cardiac diseases in dogs. We have recently identified two deletion polymorphisms in the canine adrenoreceptor 1 (ADRB1) gene.We hypothesized that canine ADRB1 deletions would alter the structure of the protein, as well as the heart rate response to the β-adrenergic receptor antagonist, atenolol.
View Article and Find Full Text PDFObjective: To assess survival time and adverse events related to the administration of pimobendan to cats with congestive heart failure (CHF) secondary to hypertrophic cardiomyopathy (HCM) or hypertrophic obstructive cardiomyopathy (HOCM).
Design: Retrospective case-control study.
Animals: 27 cats receiving treatment with pimobendan and 27 cats receiving treatment without pimobendan.
Article Synopsis
- Familial subvalvular aortic stenosis (SAS) is a hereditary heart defect commonly seen in Newfoundlands, golden retrievers, and children, with a focus on identifying genetic causes.
- Researchers studied 93 Newfoundland dogs and 180 control dogs to explore the inheritance pattern of SAS, indicating it follows an autosomal dominant pattern and is linked to a specific genetic variant in the PICALM gene.
- The findings not only suggest a way to test for this genetic variant in dogs to inform breeding practices and reduce SAS prevalence but also propose a broader relevance of PICALM in understanding congenital heart defects across different species.