Publications by authors named "Yamin Soe"
Cisplatin is a platinum-based compound that is widely used for treating inoperable oral squamous cell carcinoma (OSCC) in Japan; however, resistance to cisplatin presents a challenge and innovative approaches are required. We aimed to investigate the therapeutic potential of targeting the chemokine receptor CXCR4, which is involved in angiogenesis and tumor progression, using the CXCR4 inhibitor AMD3100, in combination with cisplatin. AMD3100 induced necrosis and bleeding in OSCC xenografts by inhibiting angiogenesis.
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- Cancer cells are genetically unstable, leading to diverse subclones within tumors, which complicates treatment strategies, particularly in oral squamous cell carcinoma (OSCC).
- CX3C motif ligand 1 (CX3CL1) exhibits both anti- and pro-tumor functions depending on the tumor phenotype, influencing cancer behavior differently in laboratory conditions versus the living organism.
- In aggressive OSCC, CX3CL1 promotes metastasis through the lymphatic system, correlating with poorer patient outcomes, making it a critical marker for monitoring cancer progression.
Mesenchymal stem cell (MSC) therapy is a promising approach to curing bone diseases and disorders. In treating genetic bone disorders, MSC therapy is local or systemic transplantation of isolated and in vitro proliferated MSC rather than bone marrow transplantation. Recent evidence showed that bone marrow MSC engraftment to bone regeneration has been controversial in animal and human studies.
View Article and Find Full Text PDFTumor angiogenesis is one of the hallmarks of solid tumor development. The progressive tumor cells produce the angiogenic factors and promote tumor angiogenesis. However, how the tumor stromal cells influence tumor vascularization is still unclear.
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