Publications by authors named "Yamin Luo"

Article Synopsis
  • PAE (Paeonol) and GLY (Glycyrrhizic acid) are key components in a traditional Chinese medicine prescription used for treating chronic migraines, showing significant analgesic and neuroprotective benefits.
  • The study aimed to investigate how the combination of PAE and GLY affects migraine-like symptoms in rats and involved various experimental techniques to assess their impact.
  • Results indicated that the treatment effectively increased pain threshold and adjusted serotonin levels while modifying gene expression related to the GABAergic pathway, suggesting a mechanism for migraine symptom alleviation.
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Article Synopsis
  • This study aimed to explore how Mahuang Xixin Fuzi decoction (MXFD) affects migraines through its pharmacological properties.
  • Researchers induced migraines in rats using nitroglycerin and treated them with MXFD for a week, analyzing blood and urine for changes in metabolites.
  • The results showed that MXFD reduced migraine symptoms by normalizing nine metabolites and targeting several key molecules involved in migraine pathways.
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Ethnopharmacological Relevance: Shaoyao Gancao Decoction (SGD) is well known as an effective prescription for analgesia composed of two herbs, and is noted as traditional Chinese medicine morphine. It is widely used in various conditions causing pain, including migraine. However, there is currently no research exploring the mechanism of action in the treatment of migraines.

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Context: Myelodysplastic syndromes (MDSs) are characterized by ineffective hematopoiesis, excessive apoptosis, and the aberrant expression of a number of cytokines. The genes encoding these cytokines are significantly polymorphic. It is unknown whether these cytokine polymorphisms are associated with, and may therefore be playing a role in the pathogenesis of, MDS.

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To determine the diagnostic significance of the kappa/lambda ratio in germinal center (GC) B cells in Hashimoto thyroiditis (HT), we used 4-color flow cytometry to immunophenotype 27 samples (21 patients) of well-characterized HT B-cell clonality was analyzed further by polymerase chain reaction (PCR) of the immunoglobulin heavy chain (IgH) and bcl-2/IgH fusion genes using DNA extracted from aspirate smears and/or paraffin-embedded tissues. By flow cytometric analysis, the CD10+ GC B cells had a higher mean +/- SD kappa/lambda ratio than the CD10- B cells (5.1 +/- 3.

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We immunohistochemically defined the histogenesis of posttransplantation lymphoproliferative disorders (PTLDs; B-cell phenotype) occurring after allogeneic T cell-depleted hematopoietic stem cell transplantation (HSCT; n = 15) or solid organ transplantation (SOT; n = 11) to determine whether transplantation type or morphologic subtype of PTLD affected the histogenetic subtype. Immunohistochemical stains using histogenetic markers for germinal center (GC) B cells, late GC and post-GC B cells, and post-GC B cells were performed on paraffin-embedded samples. Morphologically, 14 cases were polymorphic; 12 were monomorphic.

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