The effects of a salutogenic strength-based intervention on sense of coherence and health outcomes in newly diagnosed HIV-positive MSM: A randomized controlled trial.

Background: Newly diagnosed HIV-positive men who have sex with men (MSM) often face significant psychological stress, resulting in a high prevalence of issues such as anxiety and depression. Sense of coherence, an internal strength factor, is known to offer protective effect against health challenges. However, interventions specifically designed to enhance sense of coherence in this population remain limited.

Facet-Selective Growth of Dots-on-Plate II-VI Heterostructures for Efficient Photocatalytic Hydrogen Evolution.

High-level control over the surface and interface of II-VI heterostructures is crucial for enhancing charge separation and optimizing active sites, thus improving photocatalytic performance. However, due to variations in surface energy and atomic arrangement among different crystal facets, achieving selective growth of specific facets remains a significant challenge. Herein, we have achieved the selective growth of CdSe or ZnSe dots on the lateral facets or basal facets of two-dimensional CdS or ZnS nanoplates by carefully selecting Se source precursors with different reaction activities.

Mental health first aid training and assessment for healthcare professionals and medical nursing students: a systematic review.

Purpose: To summarize the effect of mental health first aid (MHFA) on paramedics and medical nursing students and provide direction to future training and research.

Methods: Seven databases, including Web of Science, PubMed, Embase, Cochrane, China Knowledge, Wanfang, and China Biomedical Literature Database, were searched for relevant studies from database establishment up to January 31, 2023. The Cochrane risk of bias tool was used to assess the quality of randomized controlled trials, qualitative studies, and single-armed trials on the basis of the literature evaluation criteria developed by the JBI Center for Evidence-Based Healthcare in Australia.

Accelerated Screening of Covalent Organic Frameworks for Ethylene Glycol/1,2-Butanediol Separation by Interpretable Machine Learning.

The separation of ethylene glycol (EG) and 1,2-butanediol (1,2-BDO) azeotrope in the synthesis process of EG via coal and biomass is becoming increasingly commercial and of environmental importance. Selective adsorption is deemed as the most promising method because of energy savings and environment favorability. In this study, we developed an interpretable decision tree (DT) model to facilitate high-throughput screening of covalent organic frameworks (COFs) as adsorbents for the separation of EG/1,2-BDO mixtures, achieving an R value of 0.

Protocol of the Nurses' Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study.

Introduction: Due to high workload, shift work and shortage of human resources, nurses are vulnerable to various mental health problems which are significantly related to their physical health, patient safety and healthcare quality. The long-term monitoring of nurses' mental health and identifying its risk factors are necessary. Accounting for more than one-fifth of global nurses, Chinese nurses have a demanding healthcare workload, especially in tertiary hospitals, yet there is no national cohort concerning their mental health and associated factors.

Concoctive principles of detoxification and retention of the main toxicity of Tripterygium wilfordii and its anti-inflammatory efficacy by concocting with the medicinal excipient Spatholobi Caulis juice.

Tripterygium wilfordii (TW), which has severe hepatotoxicity, is commonly used as anti-rheumatism. Using the juice of auxiliary herbs in concocting poisonous herbs is a conventional method for toxicity reduction or efficacy enhancement. Traditional Chinese Pharmacy textbooks record that Spatholobi Caulis (SC) can alleviate the side effects caused by TW and also possesses excellent hepatoprotective effect.

The Role of ROS and Its Sources in Tumorigenesis: Friend or Foe?

Ponicidin has demonstrated effectiveness against HCC by promoting mitochondria apoptosis and generating ROS through the stabilization of the Keap1-PGAM5 complex. However, ROS can exhibit both tumor-promoting and tumor-suppressing activities in cancers, and exhibit different effects depending on its source-mtROS vs non-mtROS. Additionally, since ROS from different sources possesses distinct functions, mitochondria-targeted antioxidants, and non-targeted antioxidants may have entirely different effects on cancer progression.

Network of job demands-resources and depressive symptoms in critical care nurses: a nationwide cross-sectional study.

Background: Critical care nurses are vulnerable to depression, which not only lead to poor well-being and increased turnover intention, but also affect their working performances and organizational productivity as well. Work related factors are important drivers of depressive symptoms. However, the non-liner and multi-directional relationships between job demands-resources and depressive symptoms in critical care nurses has not been adequately analyzed.

Development and optimization of an mRNA-vectored single-chain IgA1 isotype monoclonal antibody with potential to treat or prevent dengue virus infection.

Dengue virus (DENV) is a rapidly expanding infectious disease threat that causes an estimated 100 million symptomatic infections every year. A barrier to preventing DENV infections with traditional vaccines or prophylactic monoclonal antibody (mAb) therapies is the phenomenon of Antibody-Dependent Enhancement (ADE), wherein sub-neutralizing levels of DENV-specific IgG antibodies can enhance infection and pathogenesis rather than providing protection from disease. Fortunately, IgG is not the only antibody isotype capable of binding and neutralizing DENV, as DENV-specific IgA1 isotype mAbs can bind and neutralize DENV while without exhibiting any ADE activity.

Artificial intelligence and glaucoma: a lucid and comprehensive review.

Glaucoma is a pathologically irreversible eye illness in the realm of ophthalmic diseases. Because it is difficult to detect concealed and non-obvious progressive changes, clinical diagnosis and treatment of glaucoma is extremely challenging. At the same time, screening and monitoring for glaucoma disease progression are crucial.

Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults.

Background: Although emerging evidence suggests that indole derivatives, microbial metabolites of tryptophan, may improve cardiometabolic health, the effective metabolites remain unclear. Also, the gut microbiota that involved in producing indole derivatives are less studied. We identified microbial taxa that can predict serum concentrations of the key indole metabolite indole-3-propionic acid (IPA) at population level and investigated the associations of indole derivatives and IPA-predicting microbial genera with cardiometabolic risk markers.

Orchestrated desaturation reprogramming from stearoyl-CoA desaturase to fatty acid desaturase 2 in cancer epithelial-mesenchymal transition and metastasis.

Background: Adaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl-CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have recently been highlighted. However, how tumors initiate and sustain their self-sufficient FA desaturation to maintain phenotypic transition remains elusive.

Transdermal Insulin Delivery Using Ionic Liquid-Mediated Nanovesicles for Diabetes Treatment.

Transdermal insulin delivery is a promising method for diabetes management, providing the potential for controlled, sustained release and prolonged insulin effectiveness. However, the large molecular weight of insulin hinders its passive absorption through the stratum corneum (SC) of the skin, and high doses of insulin are required, which limits the commercial viability. We developed ethosome (ET) and -ethosome (TET) nanovesicle formulations containing a biocompatible lipid-based ionic liquid, [EDMPC][Lin], dissolved in 35% ethanol.

Introduced paeoniflorin reduces the main toxicity induced by diosbulbin B, the major toxic compound of L.: involved inhibiting inflammation and ferroptosis.

Rhizoma Dioscoreae Bulbiferae (HYZ) is a widely utilized herb in clinical practice, known for its significant biological activities. However, the associated hepatotoxicity poses limitations to its application. Our previous research indicated that the effective mitigation of HYZ-induced hepatotoxicity through the concoction with Radix Paeoniae Alba medicinal juice involves the incorporation of paeoniflorin (Pae) and a reduction in diosbulbin B (DB), the primary toxic compound in HYZ.

Anisotropic Single-Crystal Proton Conduction in a Sodium Chain-Based Coordination Polymer.

Coordination polymers (CPs) have been identified as promising candidate materials in the field of proton conduction owing to their customizable and diverse structures. However, research on CPs based on alkali metal ions has been less advanced, and the mechanism of proton transport in these materials remains unclear. Herein, a new coordination polymer, [Na(pytet)(Hdat)(HO)]·2HO (abbreviated as ) (pytet = pyrene-1,3,6,8-tetrasulfonate, dat = 2-hydroxy-4,6-diamino-1,3,5-triazine), has been synthesized based on the starting materials of Napytet and 2-chloro-4,6-diamino-1,3,5-triazine, with the latter undergoing in situ transformation to dat under hydrothermal conditions.

Head nurse ethical competence and transformational leadership: a cross-sectional study.

Background: Ethical competency is important to head nurses' transformational leadership, however, few researches have explored their correlation, Additionally, most studies used variable-oriented approach to examine ethical competence, without considering it as a multidimensional concept. This study aimed to identify the latent profiles of head nurses' ethical competence and examine differences in transformational leadership across latent profiles.

Methods: Convenience sampling was used to recruit 329 head nurses from four tertiary hospitals in Changsha, Hunan province, China.

Duplicate MADS-box genes with split roles and a genetic regulatory network of floral development in long-homostyle common buckwheat.

The classic ABC model postulates how three classes of floral homeotic genes (A, B and C) work in a combinational way to confer organ identity to each whorl that make up a perfect flower in core eudicot plants. Fagopyrum esculentum (Polygonaceae) produces dimorphic flowers with single whorl showy tepals, representing a considerable difference with most core eudicots flowers. Here, we explain in detail the function of a duplicated pair of floral homeotic genes involved in the formation of tepals and stamens in the LH F.

Reliability and validity of the Chinese version of the family presence risk-benefit and self-confidence scales in Chinese nurses.

Background: Controversy surrounding Family Presence during Resuscitation (FPDR) continues internationally. The attitudes of medical professionals toward FPDR are particularly important for its clinical implementation. Currently, there is a lack of validated tools to evaluate medical professionals' perceptions of FPDR in China.