Publications by authors named "Yamila Gazzoni"

Article Synopsis
  • This study investigates the effects of cytokine storms in COVID-19 patients from Córdoba, Argentina, comparing data from the first two waves of the pandemic to understand links between demographics, comorbidities, and disease outcomes.
  • Results showed that patients during the second wave were younger and had fewer comorbidities, with distinct cytokine and chemokine profiles, while pre-existing conditions did not significantly impact cytokine levels.
  • The research identified specific inflammatory markers, such as IL-6 and C-reactive protein, that could help predict patient outcomes, particularly differentiating between mortality and recovery during the first wave of infections.
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During infections with protozoan parasites or some viruses, T cell immunosuppression is generated simultaneously with a high B cell activation. It has been described that, as well as producing antibodies, plasmablasts, the differentiation product of activated B cells, can condition the development of protective immunity in infections. Here, we show that, in infection, all the plasmablasts detected during the acute phase of the infection had higher surface expression of PD-L1 than other mononuclear cells.

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Trophoblast cell differentiation is of paramount importance for successful pregnancy. Krüppel-like factor 6 (KLF6), a transcription factor with diverse roles in cell physiology and tumor biology, is required for trophoblast differentiation through the syncytial pathway. Herein, we demonstrate that extravillous trophoblast (EVT) cell migration and mesenchymal phenotype are increased upon KLF6 downregulation or the expression of a deletion mutant lacking its transcriptional regulatory domain (KΔac).

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Treatment with anti-CD20, used in many diseases in which B cells play a pathogenic role, has been associated with susceptibility to intracellular infections. Here, we studied the effect of anti-CD20 injection on CD8 T cell immunity using an experimental model of infection, in which CD8 T cells play a pivotal role. C57BL/6 mice were treated with anti-CD20 for B cell depletion prior to infection.

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