The genetics of multiple sclerosis in Latin America.

Background: In today's globalised world, the heterogeneity of diseases such as multiple sclerosis has been studied since it has been suggested that ethnic differences, in conjunction with geographical and environmental factors, influence its incidence and prevalence.

Aim: Based on this, an attempt has been made to identify the genetic factors that may confer risk or protection, not only for developing multiple sclerosis but also for determining the course of its evolution.

Results: In Latin America we have some data about this, which have been replicated in different populations in the entire region, with very different results compared with other regions, which could explain not only the different frequencies in some populations, such as Caucasians, but also the course of the disease and the response to actual treatments.

Electrophysiological correlates of decision making impairment in multiple sclerosis.

Although previous studies have shown that patients with multiple sclerosis (MS) may exhibit impaired decision making (DM), the specific neuro-cognitive processes that underlie this deficiency remain unknown. Inefficient DM may occur due to poor option assessment or a deficit in the evaluation of choice outcomes. This study uses, for the first time, the event-related potential (ERP) technique to analyze these DM subprocesses in patients with MS.