A Poly(2,7-anthrylene) with peri-Fused Porphyrin Edges.

Anthracene has served as an important building block of conjugated polymers with the connecting positions playing a crucial role for the electronic structures. Herein, anthracene units have been coupled through their 2,7-carbons to develop an unprecedented, conjugated polymer, namely, poly(2,7-anthrylene) featuring additional peri-fused porphyrin edges. The synthesis starts from a 2,7-dibromo-9-nickel(II) porphyrinyl-anthracene as the pivotal precursor.

Effect of recombinant human growth hormone plus vitamin D on development and lipid metabolism in children with growth hormone deficiency.

The combination of rhGH and vitamin D has been suggested as a potential therapeutic approach for children with GHD. This retrospective study aimed to investigate the impact of recombinant human growth hormone plus vitamin D on development and lipid metabolism in children with growth hormone deficiency. A total of 198 children treated in our hospital from December 2011 to December 2021 were recruited.

Dimerized Nitrogen-Annulated Perylene Synthesized from 1,6-Diazecine as Chiral Emitter.

In this work, nitrogen-annulated perylene (NP) was dimerized into one framework connected by two nitrogen atoms, generating the target molecule of DNP-DA. Owing to the substructure of 1,6-diazecine ten-membered ring, DNP-DA illustrates helical chirality with moderate dissymmetry factor, elevated molecular levels, expanded conjugation and supramolecular interactions with acceptors etc. Notably, DNP-DA represents a limited example of nitrogen-perylene based CPL emitter with g around 6×10 .

Circular RNA circESPL1 knockdown alleviates lipopolysaccharide (LPS)-induced lung cell injury via sponging miR-326 to regulate MAPK14.

Background: Infantile pneumonia (IP) is a common inflammatory disease, which brings a heavy burden to young children's health. Previous studies suggested that circular RNA (circRNA) hsa_circ_0026579 (also called circESPL1) was significantly upregulated in pneumonia patients, which was associated with the disease severity. This subject aimed to explore the functional effects and potential regulatory mechanism of circESPL1 on lipopolysaccharide (LPS)-induced lung cell injury.