Publications by authors named "Yamei Li"
Article Synopsis
- Chrysanthemum indicum, Chrysanthemum morifolium, Buddleja officinalis, and Sophora japonica are traditional Chinese medicinal flowers known for their benefits in "clearing the liver" and "improving vision," primarily due to their flavonoid content.
- The study aims to explore how the flavonoids from these flowers can help prevent and treat liver and eye diseases, using various databases to gather relevant research on conditions like hepatitis and cataracts.
- Findings reveal that these flowers contain 125 flavonoids that support liver and eye health by regulating issues like oxidative stress and inflammation, highlighting their potential as effective treatments in traditional medicine.
Article Synopsis
- The study investigates the effectiveness of the traditional Chinese medicine Fuke Qianjin capsule (FKQ) in treating sequelae of pelvic inflammatory disease (SPID), which affects female reproductive organs and surrounding tissue.
- FKQ shows protective effects against pathogenic bacteria linked to SPID, reduces uterine damage, and minimizes inflammation by inhibiting pro-inflammatory cytokines and balancing immune cell types in a rat model.
- The research concludes that FKQ operates through a combination of antibacterial, anti-inflammatory, reparative, and immune-enhancing actions to treat SPID effectively.
Article Synopsis
- A study was conducted to investigate the effectiveness of different edge designs for occlusal veneers on maxillary first molars, emphasizing the need for standardized clinical protocols due to varying research outcomes.
- The research involved creating 3D models of teeth and testing three edge designs (SFL, CFL, SCI) with varying thicknesses (0.5 mm and 1.0 mm), using finite element analysis to assess stress distribution under bite forces.
- Results showed that increased veneer thickness raised stress in SFL and CFL designs, while SCI saw reduced stress; however, SCI also risked exceeding adhesive strength, suggesting potential issues with this design in clinical settings.*
Article Synopsis
- The study investigates the effectiveness of the Six-Codon assay for detecting cephalosporin resistance, crucial for improving WHO-recommended treatments.
- A thorough evaluation involved 397 known sequence isolates and 773 confirmed isolates across multiple locations, demonstrating high sensitivity (86.84%) and specificity (99.59%) for predicting antimicrobial resistance.
- The results suggest that the Six-Codon assay can be effectively used on clinical samples, offering adaptable strategies for resistance prediction and aiding in population health management.
Ethnopharmacological Relevance: Fuke Qianjin Capsule (FKC), a traditional Chinese medicine commonly employed for treating endometritis, lacks reported treatment mechanisms.
Aim Of The Study: The aim of the present study was to explore the role and mechanism of FKC in lipopolysaccharide (LPS)-induced endometritis.
Materials And Methods: The main active ingredients of FKC were identified via high-performance liquid chromatography (HPLC) in conjunction with standard substances.
Article Synopsis
- The study aimed to assess whether a combination of continuous low-dose norepinephrine infusion and goal-directed fluid therapy (GDFT) could reduce postoperative pulmonary complications (PPCs) in patients undergoing lung surgery, compared to GDFT alone or standard fluid treatment.
- Conducted at the First Affiliated Hospital of Anhui Medical University with 184 patients, the randomized controlled trial categorized patients into three groups: standard fluid treatment, GDFT, and the norepinephrine plus GDFT combination.
- Results showed that the norepinephrine group had significantly lower PPC rates than the standard treatment group (11.5% vs 27.9%), but no significant difference was found between the norepinephrine
Article Synopsis
- Edentulism, a common oral health issue mainly affecting the elderly, is linked to various diseases, with its connection to physical activity still unclear.
- An analysis using data from the CHARLS study with 6,480 participants showed that physically active individuals had a 24% lower risk of edentulism compared to those who were inactive, particularly at moderate activity levels of 1,800-3,000 MET-minutes/week.
- The research concluded a U-shaped relationship between physical activity volume and edentulism, indicating both insufficient and excessive physical activity could lead to higher risks, with moderate levels offering the most protection.
Article Synopsis
- Pathogen infections are a major global public health issue, and bile acid (BA) metabolism plays a critical role in regulating host immunity and microbial infection.
- The study investigated how viral (VSV) and bacterial (LPS) infections alter BA metabolism, revealing significant changes in circulating BA profiles, particularly an increase in taurine-conjugated BAs and a decrease in unconjugated BAs.
- The research highlights the impact of infections on BA biosynthesis enzymes and their receptors, suggesting that targeting BA metabolism could potentially enhance innate immunity and help control infections.
Article Synopsis
- There is currently no standardized treatment for post-stroke cognitive impairment and depression (PSCCID), leading to a need for effective interventions.
- This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) on PSCCID symptoms and its impact on brain function using resting-state fMRI in a trial with 30 patients.
- Results showed that rTMS significantly improved cognitive and depressive symptoms compared to a control group, with enhanced functional connectivity in brain regions associated with mood and memory, suggesting rTMS may help in clinical recovery for these patients.
Article Synopsis
- Arbutin, an optical isomer popular in skin whitening products, has two forms: α-arbutin and β-arbutin, but how they penetrate skin hasn't been fully understood yet.* -
- Research showed that α-arbutin penetrates porcine skin more effectively than β-arbutin, affecting skin structure differently; α-arbutin changes the secondary structure of proteins, while β-arbutin interacts more with skin lipids like ceramides, restricting its penetration.* -
- The study highlights that the different spatial arrangements of the arbutin forms influence their interactions with skin components, leading to varied effectiveness, and suggests this could apply to other isomers in similar studies.*
Article Synopsis
- The study investigates the characteristics and resistance levels of sexually transmitted infections (STIs) in Shenzhen, China, with a focus on sociodemographic factors.
- A total of 7,886 sexually active participants were screened for various STI-related organisms, revealing that being single, divorced, or having lower education increases the risk of STI detection.
- High levels of antimicrobial resistance were found, with a significant percentage of samples showing mutations linked to treatment resistance, indicating a need for more awareness and action regarding STI prevention and treatment in specific high-risk groups.
Article Synopsis
- Senecavirus A (SVA) is a serious virus that causes vesicular disease in pigs, prompting the need for an effective vaccine.
- Researchers created a nanoparticle vaccine using a peptide from another virus, combining it with SVA proteins to enhance immune response.
- Trials in mice and pigs showed that the nanoparticle vaccine generated strong immune protection, with an 80% success rate in preventing SVA infection, indicating it could be a promising solution for controlling SVA outbreaks in swine.
Article Synopsis
- * Four inorganic elements—manganese (Mn), bismuth (Bi), cadmium (Cd), and rubidium (Rb)—were identified as key markers that distinguish the two species, with specific content differences observed.
- * The research provides insights into how these elemental differences could affect the medicinal properties of the plants and suggests a direction for future studies on their quality control and pharmacological effects.
Article Synopsis
- Anti-PD-1 immunotherapy shows promise, but many cancer patients do not respond, highlighting the need for better predictive biomarkers.
- The study reveals that the receptor P2RY6 is often overexpressed in cancers, promoting immune evasion and creating a tumor microenvironment that supports tumor growth and resistance to immunotherapy.
- Targeting P2RY6 could offer a precision immunotherapy strategy for patients with tumors exhibiting high levels of this receptor, as its absence does not adversely affect overall mouse health.
Article Synopsis
- Inflammation is linked to many chronic diseases, prompting research into anti-inflammatory drugs and foods, particularly those derived from plants.
- Phenolic acids, a key group of bioactive compounds from medicinal and edible homologous plants, demonstrate significant anti-inflammatory properties and potential for drug and functional food development.
- The review covers the types, structures, distribution, and mechanisms of phenolic acids in treating inflammatory diseases, highlighting their effects on gut microbiota and immune responses while suggesting the need for further research on their structure-activity relationships.
Article Synopsis
- - The study investigated how different levels and types of iron supplements affect semen quality in 56 Topeka E line boars, focusing on various iron sources like Gly-Fe and MHA-Fe compared to a control group with ferrous sulfate.
- - Results indicated that lower dietary iron levels in certain groups did not negatively impact serum iron or hemoglobin levels, but significantly reduced inflammatory markers and lower sperm damage, suggesting improved semen quality.
- - Overall, while MHA-Fe seemed to enhance semen quality by decreasing abnormal sperm rates and inflammatory responses, Gly-Fe did not show significant benefits in improving semen quality in the boars.
Article Synopsis
- A mouse model of nonalcoholic fatty liver disease (NAFLD) was created using a specialized diet that caused significant weight gain and liver fat buildup in mice.
- This diet also negatively impacted the gut microbiome, leading to less diversity and changes in microbial metabolites, which affected colon health and function.
- The study concluded that NAFLD is linked to alterations in gut microbes, oxidative stress, immune response issues, and weakened barrier function in the colon.
Article Synopsis
- Schistosomiasis is a long-standing parasitic disease in China, with traditional Chinese medicine (TCM) offering historical insights and potential modern applications for its treatment.
- This study aims to analyze TCM's effectiveness against schistosomiasis by reviewing its molecular mechanisms, active ingredients, and relevant treatment formulas to enhance clinical options.
- Findings indicate that TCM provides notable antischistosomal and immunomodulatory effects, particularly beneficial for schistosomal liver fibrosis, and combining it with praziquantel shows better results than using either treatment alone.
Article Synopsis
- * A study used a rat model with NASH to test various treatments (NC, curcumin, metformin) over 4 weeks while analyzing liver function and lipid metabolism through various assays.
- * Results indicated NC improved liver function by lowering key liver enzyme levels and blood lipids while also impacting the expression of certain proteins related to lipid metabolism in the liver.
Article Synopsis
- * The research identified key sterilization methods (ethanol, fungicide, and sterile water) and found that the best growth medium for plant propagation includes a combination of 6-benzylaminopurine (6-BA) and indoleacetic acid (IAA).
- * Results showed that using α-naphthaleneacetic acid (NAA) improved rooting success, with rates increasing from 78% to 100% as NAA concentration rose, while a 1:1 mix of red soil and sand led to 100% survival of seedlings.
Article Synopsis
- * A study identified certain bacteria, particularly B6, that are more abundant in children with obesity and NAFLD, and found B6 produces a metabolite called tyramine that can worsen NAFLD symptoms.
- * The research showed that tyramine activates PPAR-γ, leading to increased fat accumulation and inflammation in the liver, providing insights that could help develop new treatment strategies for NAFLD.
Article Synopsis
- - The study investigates the use of supramolecular solvents (SUPRAS) as an eco-friendly and efficient technique for extracting phenolic compounds, which are known for their antioxidant properties, from plants, addressing the scarcity of research in this area.
- - A green ultrasound-assisted SUPRAS method was developed and optimized for the simultaneous extraction of three phenolic acids, showing significantly higher efficiency and antioxidant capacity compared to traditional organic solvents.
- - Microscopy and molecular dynamics simulations confirmed that the phenolic compounds were encapsulated within SUPRAS droplets, leading to superior extraction due to increased surface area and stronger interactions, thereby supporting the promising application of SUPRAS in natural product extraction.
Article Synopsis
- Artificial intelligence (AI) is making significant strides in sleep medicine, with a study aimed at evaluating AI-assisted sleep staging in China using results from the 2nd China Intelligent Sleep Staging Competition.
- The analysis focused on the performance of 10 children's track teams and 13 adult track teams, revealing peak accuracies of 88.96% for children and 80.46% for adults, with notable differences in performance during stage transitions and subject variations.
- The study concluded that while AI can potentially surpass physician accuracy and operates quickly, enhancing AI's ability to classify specific sleep stages and improve performance consistency across different subjects is crucial for effective clinical application.
Article Synopsis
- The study focuses on the genomic structure of crab-eating and rhesus macaques, addressing the need for better understanding of their genetic differences and similarities.
- Researchers provide a complete genome assembly for the crab-eating macaque and 20 haplotype-resolved assemblies to explore significant genomic variations between the two species and their implications.
- Findings include that macaques have lower segmental duplication and longer centromeres than humans, as well as differences in genetic variants and alternative splicing, which may relate to metabolic and evolutionary traits, enhancing their use in biomedical research.
Article Synopsis
- Gold nanoparticles (AuNPs)-based assays are becoming popular for quickly detecting food hazards due to their rapid response and effectiveness.
- This research introduces a green microfluidic method for synthesizing stable, size-controllable pepsin-doped AuNPs (AuNPs@Pep) using glucose-pepsin, making the process efficient and eco-friendly.
- The study highlights how AuNPs@Pep enhances detection sensitivity for small molecules like florfenicol and allergens like ovalbumin, achieving significant improvements in detection limits with both "signal-off" and "signal-on" formats in microfluidic paper devices.