Publications by authors named "Yamato Horaguchi"
Since 6-prenylnaringenin (6-PNG) was recently identified as a novel T-type calcium channel blocker with the IC value around 1 µM, a series of flavanone derivatives were designed, synthesized and subsequently evaluated for T-channel-blocking activity in HEK293 cells transfected with Ca3.2 T-type channels using a patch-clamp technique. As a result, several new flavanones blocked Ca3.
View Article and Find Full Text PDFArticle Synopsis
- Researchers investigated herbal extracts for their ability to block T-type calcium channels (T-channels) linked to chronic pain, identifying sophoraflavanone G (SG) and its hop-derived analogues (2S)-6-prenylnaringenin (6-PNG) and (2S)-8-PNG as effective inhibitors.
- The active compounds showed varying potency against T-channels, with 6-PNG and 8-PNG demonstrating reversible inhibition in certain cellular models, while SG had a stronger effect overall.
- In animal studies, these compounds effectively reduced pain-related behaviors without significant side effects, suggesting their potential as therapeutic options for neuropathic and visceral pain.