Publications by authors named "Yamato Hashizume"
Nicotinamide adenine dinucleotide (NAD) supplies energy for deoxidation and anti-inflammatory reactions fostering the production of adenosine triphosphate (ATP). The kidney is an essential regulator of body fluids through the excretion of numerous metabolites. Chronic kidney disease (CKD) leads to the accumulation of uremic toxins, which induces chronic inflammation.
View Article and Find Full Text PDFDual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease.
Am J Physiol Renal Physiol
May 2020
Protease-activated receptors (PARs) are coagulation protease targets, and they increase expression of inflammatory cytokines and chemokines in various diseases. Of all PARs, previous reports have shown that PAR1 or PAR2 inhibition is protective against diabetic glomerular injury. However, how PAR1 and PAR2 cooperatively contribute to diabetic kidney disease (DKD) pathogenesis and whether dual blockade of PARs is more effective in DKD remain elusive.
View Article and Find Full Text PDFTadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.
Biochem Biophys Res Commun
January 2020
Article Synopsis
- Tadalafil, a medication that targets erectile dysfunction, has shown potential in reducing preeclampsia (PE) and fetal growth restrictions (FGR) in mouse models during early clinical trials.
- The study aimed to investigate the effects of tadalafil on a specific mouse model of PE known as the reduced uterine perfusion pressure (RUPP) model, which mimics the condition.
- Results indicated that tadalafil improved maternal health by lowering blood pressure and enhancing embryo development, while also normalizing increased levels of a harmful protein associated with PE in the placenta.