Publications by authors named "Yamakami J"
We evaluated the secondary COVID-19 incidence among uninfected hospitalized patients after nosocomial COVID-19 exposure. An exposure source of SARS-CoV-2 was hospitalized patients or healthcare personnel (HCP) newly diagnosed as having COVID-19. Patients exposed to a COVID-19-infected patient in a shared room more frequently developed COVID-19 than those exposed to an infected HCP.
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- Contrast media agents, crucial for CT diagnosis, can lead to severe allergic reactions like anaphylaxis, particularly with repeated use.
- A quality improvement initiative at a Japanese hospital analyzed CT processes and identified high-risk areas related to patient allergy information and post-exam protocols, using failure modes and effects analysis (FMEA).
- The study highlights the effectiveness of FMEA in enhancing patient safety in healthcare, suggesting that adopting new methods can significantly lower risks associated with contrast media in radiology.
Article Synopsis
- The study investigated the anti-inflammatory effects of theophylline using a rat model of carrageenan-induced edema, showing that theophylline doses between 5-100 mg/kg reduced swelling in a dose-dependent manner.
- Theophylline's metabolites did not show significant anti-inflammatory effects when tested at an equivalent dose of 50 mg/kg.
- The results indicated that theophylline's anti-inflammatory action may involve the glucocorticoid-glucocorticoid receptor system since pretreatment with related inhibitors reversed its effects.
Stereoselective transport of histidine in rat lung microvascular endothelial cells.
Am J Physiol Lung Cell Mol Physiol
June 2002
Article Synopsis
- The study explored how L- and D-histidine are transported across the blood-lung barrier using rat lung microvascular endothelial cells.
- L-histidine showed a saturable uptake process influenced by metabolic inhibitors and Na(+)-K(+)-ATPase inhibitors, indicating a Na(+)-dependent transport mechanism.
- In contrast, D-histidine uptake remained unaffected by the same inhibitors, suggesting distinct transport pathways for L- and D-histidine in rat LMECs.
Objective And Design: L-Histidine decarboxylase (HDC) is the primary enzyme regulating histamine biosynthesis. This study was carried out to examine whether the cultured rat brain microvascular endothelial cells (BMEC), which constitute the blood-brain barrier (BBB), have the ability to form histamine, and whether HDC mRNA is expressed in rat BMEC.
Material: Male, 3-week-old Wistar rats were used.
The transport characteristics of l- and d-histidine through the blood-brain barrier (BBB) were studied using cultured rat brain microvascular endothelial cells (BMEC). l-Histidine uptake was a saturable process. A decrease in incubation temperature from 37 to 0 degreesC or the addition of metabolic inhibitors (DNP and rotenone) reduced the uptake rate of l-histidine.
View Article and Find Full Text PDFThe blood concentrations of 5-hydroxytryptamine (5-HT) and its metabolites, 5-hydroxyindoleacetic acid (5-HIAA) and N-acetyl 5-HT were assayed by in-vivo microdialysis and a highly sensitive HPLC procedure that was originally developed to analyse CNS mediators. We investigated the effects of histamine-receptor antagonists on 5-HT metabolism and its release into the blood of rats. The mean basal levels of 5-HT, 5-HIAA and N-acetyl 5-HT in the blood measured by in-vivo microdialysis were 77.
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