Ag(I)-Mediated Annulation of 2-(2-Enynyl)pyridines and Propargyl Amines to Access 1-(2-Pyrrol-3-yl)indolizines.

An effective Ag(I)-mediated annulation of 2-(2-enynyl)pyridines and propargyl amines was developed, unexpectedly affording a broad range of functionalized 1-(2-pyrrol-3-yl)indolizines in moderate to excellent yields. The developed method is characterized by operational simplicity, ready availability of starting materials, high regioselectivity, and broad substrate scope under mild reaction conditions. The Ag(I)-promoted cyclization of 2-(2-enynyl)pyridines and propargyl amines possibly results in the formation of the spiroindolizine, the ring-opening rearrangement of which may give the 1-(2-pyrrol-3-yl)indolizine.

Hsa_circ_0043603 promotes the progression of esophageal squamous cell carcinoma by sponging miR-1178-3p and regulating AADAC expression.

This study aims to investigate the regulatory impact of hsa_circ_0043,603, a circular RNA, on the progression of esophageal squamous cell carcinoma (ESCC), which ranks as the sixth leading cause of global mortality. We evaluated the expression, origin, and localization of hsa_circ_0043,603 in ESCC tumors using qRT-PCR, bioinformatics, and FISH analysis. Functional studies were conducted by manipulating the hsa_circ_0043,603 expression in Eca109 cells through overexpression and silencing plasmids.

Mechanical Behavior of Shape Memory Alloy Fibers Embedded in Engineered Cementitious Composite Matrix under Cyclic Pullout Loads.

The incorporation of superelastic shape memory alloy (SMA) fibers into engineered cementitious composite (ECC) materials can provide high seismic energy dissipation and deformation self-centering capabilities for ECC materials. Whether the SMA fibers can be sufficiently bonded or anchored in the ECC matrix and whether the mechanical properties of the SMA fibers in the ECC matrix can be effectively utilized are the key scientific issues that urgently need to be studied. In order to study the mechanical behavior of SMA fiber embedded in ECC matrix, four groups of semi-dog-bone pullout specimens were fabricated, and the cyclic pullout tests were conducted in this paper.