circ_0006988 promotes gastric cancer cell proliferation, migration and invasion through miRNA-92a-2-5p/TFAP4 axis.

To explore precise function and underlying mechanism of circ_0006988 in gastric cancer (GC). GC tissues were collected clinically, and GC cells were purchased from the company. Quantitative real-time polymerase chain reaction and western blot were used to detect mRNA and protein expression.

Ubenimex combined with Albendazole for the treatment of -induced alveolar echinococcosis in mice.

Introduction: Alveolar echinococcosis (AE) is a parasitic disease caused by and it is highly prevalent in the northern hemisphere. We have previously found that vaccination with -Leucine aminopeptidase (EM-LAP) could inhibit the growth and invasion of in host liver, and Ubenimex, a broad-spectrum inhibitor of LAP, could also inhibit invasion but had a limited effect on the growth and development of .

Methods: In this study, the therapeutic effect of Ubenimex combined with Albendazole on AE was evaluated.

Enantioselective Oxidative Stress and DNA Damage Induced by - and -metolachlor on the Earthworm .

Metolachlor is a widely used chiral herbicide. However, information on its enantioselective toxicity to earthworms, an important soil organism, remains limited. Herein, the effects of - and -metolachlor on oxidative stress and DNA damage in were investigated and compared.

Therapeutic effect on Alveolar echinococcosis by targeting EM-Leucine aminopeptidase.

Alveolar echinococcosis (AE) is a parasitic disease caused by metacestodes and it is highly prevalent in the northern hemisphere. We have previously found that vaccination with Leucine aminopeptidase (EM-LAP) induced specific immune response and had an inhibiting effect on the parasites. In this study, the therapeutic effect of recombinant EM-LAP (rEM-LAP) on AE was evaluated and verified using Ubenimex, a broad-spectrum inhibitor of LAP.

Bioinspired Artificial Nanodecoys for Hepatitis B Virus.

A facile route is presented for fabricating a new class of nanomimics that overexpress hepatitis B virus (HBV) receptor by a natural biosynthetic procedure against HBV infection. A nine-transmembrane HBV-specific receptor, human sodium taurocholate co-transporting polypeptide (hNTCP), was engineered to naturally immobilize it onto the cellular surface and subsequently trigger the budding of hNTCP-anchoring membrane vesicles (hNTCP-MVs) that favor the HBV virion. hNTCP-MVs could rapidly block HBV infection in cell models.

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway.

Objective: To investigate the effects of papaverine (PAP) on lipopolysaccharide (LPS)-induced microglial activation and its possible mechanisms.

Materials And Methods: BV2 microglial cells were first pretreated with PAP (0, 0.4, 2, 10, and 50 μg/mL) and then received LPS stimulation.

Effects of low-level laser irradiation on proliferation and functional protein expression in human RPE cells.

Low-level laser irradiation (LLLI) modulates a set of biological effects in many cell types such as fibroblasts, keratinocytes, and stem cells. However, no study to date has reported the effects of LLLI on retinal pigment epithelia (RPE) cells. The aim of this study was to investigate whether LLLI could enhance the proliferation of RPE cells and increase the expression of RPE functional genes/proteins.

Stem cell-based therapies for age-related macular degeneration: current status and prospects.

Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness both in developed and developing countries. During the past decades, the managements of neovascular AMD (wet AMD) have dramatically progressed. However, still no effective treatment for non-neovascular AMD (dry AMD) which was characterized by geographic macular atrophy.

Secondary glaucoma as initial manifestation of ring melanoma: a case report and review of literature.

Melanomas account for over 70% of adult malignancies in the eye and occur primarily in the choroid. Melanomas rarely originate in the ciliary body, with an annual incidence of approximately 1.6 cases per million.

Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients.

Background And Objective: Our objective was to investigate the efficacy and safety of dexa methasone (DEX) implant for the treatment of pseudophakic cystoid macular edema (PCME) in diabetic patients.

Study Design: This was a prospective, non-randomized, interventional case series of 43 participants. Eighteen patients were enrolled in the DEX implant group and 25 were enrolled in an intravitreal triamcinolone acetonide (IVTA) group.

Subfoveal choroidal thickness after photodynamic therapy in patients with acute idiopathic central serous chorioretinopathy.

Background: The purpose of this study was to evaluate changes in subfoveal choroidal thickness after photodynamic therapy in patients with acute idiopathic central serous chorioretinopathy (ICSCR).

Methods: This was a retrospective observational study conducted in 63 participants. The primary outcome measure was subfoveal choroidal thickness at baseline and 3 days, one week, 4 weeks, and 12 weeks after photodynamic therapy.

The effect of eradicating Helicobacter pylori on idiopathic central serous chorioretinopathy patients.

Purpose: To evaluate the effect of Helicobacter pylori (H. pylori) eradication on the remission of acute idiopathic central serous chorioretinopathy (ICSCR).

Study Design: A prospective, randomized, placebo-controlled study of 53 participants.

[Expression of mGluR1 at primary visual cortex of monocular deprivation amblyopia rat and the observing of ultrastructure].

Objective: To explore the regulation of expression of mGluR1 and the changes of neuron ultrastructure at primary visual cortex of monocular deprivation amblyopia rat within cortical period.

Methods: Taking randomized concurrent controlled trail. Establishing the model of monocular deprivation amblyopia rat.