Development of a Multifunctional Antimicrobial Peptide for Marine Antifouling by Theoretical Calculations and Experimental Approaches.

Marine biofouling poses significant challenges to the economy, safety, and reliability of marine infrastructure. While antimicrobial peptides (AMPs) have emerged as green and efficient antifouling agents, their single functionality and the complexity of preparing antifouling surfaces remain key challenges. This study introduces a multifunctional AMP with combined adhesion and antimicrobial properties, derived from 3,4-dihydroxy-l-phenylalanine (DOPA) and IP12 (sequence IRLRWRWKWPWP).

Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors.

Herein, we firstly reported a series of biphenyl compounds bearing hydroxamic acid moiety as PD-L1/class I HDACs dual inhibitors. Among them, compound displayed the strongest inhibitory activity against HDAC2 and HDAC3 with IC values of 27.98 nM and 14.

Modeling and simulation of distribution and drug resistance of major pathogens in patients with respiratory system infections.

Background: Respiratory tract infections (RTIs) are one of the leading causes of morbidity and mortality worldwide. The increase in antimicrobial resistance in respiratory pathogens poses a major challenge to the effective management of these infections.

Objective: To investigate the distribution of major pathogens of RTIs and their antimicrobial resistance patterns in a tertiary care hospital and to develop a mathematical model to explore the relationship between pathogen distribution and antimicrobial resistance.

LncRNA TCL6 regulates miR-876-5p/MYL2 axis to suppress breast cancer progression.

We explored the influence of the TCL6/miR-876-5p axis on breast cancer cell proliferation and migration. Using The Cancer Genome Atlas (TCGA) database, we evaluated the expression of TCL6 in breast cancer patients and studied its effects on cell proliferation, migration, and the cell cycle in vitro. The regulatory effect of miR-876-5p on myosin light chain-2 (MYL2) 3' untranslated regions (3'UTR) was analyzed through luciferase reporter assays, and rescue experiments confirmed TCL6-driven upregulation of MYL2 via a competitive RNA binding mechanism.

Viologen-Directed Silver-Thiocyanate-Based Photocatalyst for Rhodamine B Degradation in Artificial Seawater.

Photocatalytic degradation is a leading technology for complete mineralization of organic dyes in the ocean. In this work, a new viologen-bearing silver-thiocyanate-based photocatalyst, i.e.

Effect of the Laser Cladding Parameters on Microstructure and Elevated Temperature Wear of FeCrNiTiZr Coatings.

In order to prepare coating with good friction and wear resistance at elevated temperature on the surface of hot-working tool steel, by using a CO laser, FeCrNiTiZr high-entropy alloy coating with different laser scanning speeds (360, 480 and 600 mm/min, respectively) was successfully fabricated by using laser cladding technology on the surface of H13 steel in this paper. Phase constitutions, microhardness, microstructure, and wear characteristics of FeCrNiTiZr coatings under different laser scanning speeds were analyzed. It was determined that 480 mm/min was the optimal laser scanning speed.

Advances in Ubiquitination and Proteostasis in Retinal Degeneration.

Retinal degeneration (RD) is a group of chronic blinding diseases characterised by progressive retinal cell death. As the disease progresses, vision deteriorates due to retinal cell death and impaired retinal integrity, eventually leading to complete loss of vision. Therefore, the function and environmental homeostasis of the retina have an important impact on the pathogenesis and treatment of RD.

Impact of blood pressure variability and cerebral small vessel disease: A systematic review and meta-analysis.

Importance: Abnormal blood pressure pattern is an independent risk factor for vascular events. Blood pressure variability can predict cardiovascular and cerebrovascular disease outcomes and is closely associated with the risk of cognitive impairment. However, the relationship between blood pressure variability and cerebral small vessel disease neuroimaging markers remains unclear.

Enhancing Respiratory Symptoms: The Impact of Acupoint Application Combined with Back Tapping in Patients with Expectoration and Wheezing.

Background: Expectoration and wheezing are prevalent symptoms of respiratory diseases. Acupoint application and back tapping have shown effectiveness in alleviating cough, wheezing, and associated symptoms.

Objective: This study aimed to investigate the influence of combining acupoint application with back tapping in patients experiencing expectoration and wheezing.

Effect of molecular weight of PEI on the strength and hydrophobic performance of fiber-based papers via PEI-KH560 surface sizing.

In recent years, researchers have put much attention on the improvements and upgrades of novel wet strength agent in the papermaking fields, especially in the usage of household paper. Herein, PEI-KH560 by polyethyleneimine (PEI) and γ-glycidyl ether propyl trimethoxysilane (KH560) was synthesized with five molecular weights (Mw) of PEI at 600, 1800, 10,000, 70,000 and 750,000. Results showed that the molecular weight greatly influenced the physicochemical properties of PEI-KH560, such as the size and thermal stability.

Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators.

The avidity of cancer cells for iron highlights the potential for iron chelators to be used in cancer therapy. Herein, we designed and synthesized a novel series of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety using a ring-fusion strategy based on the structure of an iron chelator, VLX600. The antiproliferative activity evaluation against cancer cells and normal cells led to the identification of compound 3k, which displayed the strongest antiproliferative activity in vitro against A549, MCF-7, Hela and HepG-2 with IC values of 0.

Design, Synthesis, and Evaluation of 8-(-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists.

Small-molecule inhibitors targeting programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interactions can compensate for the shortcomings of antibody-based inhibitors and have attracted considerable attention, some of which have already entered clinical trials. Herein, based on our previous study on small-molecule PD-L1 inhibitors, we reported a series of 8-(-tolyl)quinazoline derivatives by the skeleton merging strategy. Homogenous time-resolved fluorescence (HTRF) assay against PD-1/PD-L1 interaction identified compound , which showed the most potent inhibition with an IC value of 23.

Serum Levels of Intercellular Adhesion Molecule 1 and Vascular Cell Adhesion Molecule 1 as Biomarkers to Predict Radiotherapy Sensitivity in Cervical Cancer.

Background: Cervical cancer is a significant global health burden, and individualized treatment approaches are necessary due to its heterogeneity. Radiotherapy is a common treatment modality; however, the response varies among patients. The identification of reliable biomarkers to predict radiotherapy sensitivity is crucial.

Risk of intracranial hemorrhage in patients using anticoagulant therapy for atrial fibrillation after cerebral microbleeds combined with acute ischemic stroke: a meta-analysis.

Objective: To evaluate intracerebral hemorrhage (ICH) risk in patients with ischemic stroke (IS) and cerebral microbleeds (CMBs) undergoing anticoagulation therapy for non-valvular atrial fibrillation (AF).

Methods: We conducted a comprehensive search across multiple databases, including Embase, PubMed, Cochrane, UpToDate, Scopus, WOS, and SinoMed. The search covered observational literature published from each database inception until February 1, 2023.

Clinical Evaluation of Curative Effect of SRM-IV Treatment System for Treating Refractory Benign Paroxysmal Positional Vertigo.

This study aimed to explore the clinical characteristics of the automatic vestibular function therapy system (SRM-IV) fully automated benign paroxysmal positional vertigo (BPPV) diagnosis and treatment system in the treatment of refractory BPPV and evaluate the clinical effect of reduction therapy. The clinical data of 39 patients with refractory BPPV who were admitted to our hospital's department of neurology from January 2020 to May 2022 were analyzed retrospectively. Eighteen, 14, and 5 patients were cured after 3, 4, and 5 reduction treatments, respectively, with the SRM-IV vertigo diagnosis and treatment system.

Penehyclidine for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery Under Combined Intravenous and Inhalation Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Trial.

Purpose: We designed this study to investigate the effect of intravenous use of penehyclidine on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.

Patients And Methods: Ninety-two Women Patients (Aged ≥ 18) Scheduled for Elective Gynecologic Laparoscopy Were Enrolled in the Current Study. Patients Were Equally Randomized Assigned Into Penehyclidine group (PHC group: received a bolus of penehyclidine 10 μg/kg during the induction of anesthesia, then followed by a continuous infusion of 10 μg/kg penehyclidine at a fixed rate of 2.

FTO protein regulates the TGF-β signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion.

Recent studies have revealed the involvement of RNA m6A modification in embryonic development; however, the relationship between aberrant RNA m6A modification and unexplained recurrent spontaneous abortion (URSA) remains unclear. In this study, we analysed the level of RNA m6A modification in trophoblasts using dot blot, RNA m6A quantification, and MeRIP assays. By integrating data from the GEO database, RNA-Seq, and MeRIP-Seq, we examined the aberrant expression of m6A methyltransferases and their downstream molecules in chorionic villus (placental) tissues.

Thermal comfort and adaptive behaviors in office buildings: A pilot study in Turpan (China) during summer.

Nowadays, evaporatively cooled office buildings commonly observed in dry hot areas in summer of China. However, few dedicated studies to record the local residents' thermal comfort and adaptability in these buildings. The contribution of adaptive comfort theory on thermal perception still remains unclear for optimizing office building design parameters.

A disposable and sensitive sensor based on a ZIF-8@graphene modified carbon paper electrode for the quantitative determination of luteolin.

Rapid and accurate determination of luteolin is of great significance for pharmaceutical quality control. Herein, a disposable and sensitive luteolin sensor was fabricated by a hydrothermal method with carbon paper as substrate where ZIF-8 grew on GR . Notably, the large specific surface area of ZIF-8 provided active sites on the electrode surface and the ability of GR to promote electron transfer greatly improved the sensitivity towards the oxidation of luteolin.

Syngas Production from Biomass Gasification: Influences of Feedstock Properties, Reactor Type, and Reaction Parameters.

Syngas from biomass gasification can be used in downstream process industries such as city gas, hydrogen production, etc. In this review, the effects of biomass feedstock properties, and gasification reaction conditions (temperature, gasifier type, etc.) on syngas properties are systematically reviewed.

Efficacy and associated neurotransmitters of digital cognitive behavior therapy for atopic dermatitis: A comparative effectiveness research.

Background: Negative emotions are a major comorbidity of atopic dermatitis (AD). Evidence that supports the effectiveness of digital cognitive behavioral therapy (dCBT) as an adjuvant therapy for AD remains limited.

Objective: To investigate the preliminary efficacy of additional dCBT and potential neurotransmitter biomarkers for AD accompanied by negative emotions.

HINT3 suppresses AKT/mTOR signaling pathway activity during breast cancer tumorigenesis through PTEN transcriptional activation.

Histidine triad nucleotide‑binding protein (HINT) belongs to the histidine triad protein family. Recent studies have demonstrated that HINT1 and HINT2 both play a pivotal role in cancer growth. However, the functions of HINT3 in various types of cancer, including breast cancer (BRCA), have not yet been fully elucidated.