Publications by authors named "Yalew Muche"
Acute myeloid leukemia (AML) is the abnormal proliferation of immature myeloid blast cells in the bone marrow. Currently, there are no universally recognized biomarkers for the early diagnosis, prognosis and effective treatment of AML to improve the overall survival of patients. Recent studies, however, have demonstrated that long noncoding RNAs (lncRNAs) are promising targets for the early diagnosis, prognosis and treatment of AML.
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- The review investigates the diagnostic accuracy of the Sysmex hematology analyzer for malaria detection, comparing it to the traditional light microscopy method.
- Data was collected from multiple electronic databases, with a total of 15 studies analyzed to assess sensitivity and specificity, showing high accuracy (95% sensitivity and 99% specificity) for the Sysmex analyzer.
- The results indicate that while the Sysmex hematology analyzer shows excellent diagnostic capabilities, there was notable heterogeneity among the studies in the meta-analysis.
Liver cancer caused by the hepatitis B virus (HBV) is the third most common cancer-related cause of death worldwide. Early detection of HBV-caused hepatic tumors increases the likelihood of a successful cure. Molecular and genetic signals are becoming more and more recognized as possible indicators of HBV-associated hepatic malignancy and of how well a treatment is working.
View Article and Find Full Text PDFLung cancer (LC) is the most common cause of cancer-related death worldwide and poses a severe threat to public health. Immunotherapy with checkpoint blockers has improved the outlook for advanced non-small cell lung cancer (NSCLC) therapy. For the treatment of patients with advanced NSCLC, antibodies such as anti-programmed death 1 (anti-PD1), anti-programmed death ligand 1 (anti-PD-L1), and anti-cytotoxic T lymphocyte-associated antigen 4 (anti-CTLA-4) are of paramount importance.
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- - Blood transfusion can improve tissue oxygenation but carries risks of complications, prompting a study at Debre Markos Comprehensive Specialized Hospital in Ethiopia to evaluate these risks among adult patients.
- - The study involved 182 patients and used various methods to gather socio-demographic and clinical data, with tests performed to assess potential transfusion complications; results indicated a 6.6% occurrence of acute transfusion reactions (ATR).
- - Factors such as a history of previous transfusions, abortion, older stored blood, and increased number of transfused units were significantly associated with higher ATR risk, highlighting the need for careful patient monitoring during transfusions.