Early detection and treatment of diabetic nephropathy.

Renal involvement in diabetes, known as diabetic nephropathy (DN), is a progressive disease and occurs as a result of direct and indirect effects of hyperglycemia. DN is a serious public health concern because it is the leading cause of end stage renal disease (ESRD) in most developed countries and is associated with increased cardiovascular mortality and morbidity. DN is characterized by an initial period of glomerular hyperfiltration, associated with progressively increasing proteinuria, followed by a gradual decline in glomerular filtration rate, resulting in ESRD.