Publications by authors named "Yalan Xiao"
DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal RNA (rRNA) processing, transcription, and translation. Its diverse functions in cancer progression and viral infections have attracted considerable attention. DDX21 exerts a pivotal function through ribosomal DNA (rDNA) transcription and rRNA processing.
View Article and Find Full Text PDFBackground: Air pollution is a potential risk factor for kidney disease; however, the impact on kidney failure exacerbation is underexplored. This study assessed the short-term effects of air pollution on hospitalization for kidney failure exacerbation.
Methods: This nationwide, time-stratified, case-crossover study included 45,249 hospitalized patients with kidney failure from 153 hospitals in 20 Chinese provinces between 2013 and 2020.
Article Synopsis
- Hematopoietic stem cells (HSCs) are crucial for producing mature blood cells, and their regulation relies on various factors, including alternative splicing, which increases protein diversity.
- The study investigates the ATP-dependent RNA helicase DHX16, finding that its absence in mice leads to severe depletion of HSCs, bone marrow failure, and high mortality rates, along with disruptions in cell cycle and protein synthesis.
- The research identifies that loss of DHX16 affects ribosome assembly and activates the p53 pathway due to altered Emg1 mRNA, suggesting that targeting Emg1 could provide therapeutic options for ribosomopathies in hematopoietic diseases.
Article Synopsis
- A recent study highlights that long-term exposure to fine particulate matter (PM) is linked to chronic liver disease, showing significant changes in liver function among over 100,000 participants in 15 Chinese cities.
- The research revealed that for every 10 µg/m³ increase in PM, there were notable increases in liver enzymes and triglycerides, along with decreases in essential proteins, indicating liver damage.
- Animal experiments and cell studies demonstrated that PM leads to liver inflammation, fat accumulation, and fibrosis, with the loss of the polarity protein Par3 playing a critical role in this liver injury process.
Background: Studies on the association of greenness with respiratory health are scarce in developing countries, and previous studies in China have focused on only one or two indicators of lung function.
Objective: The study aims to evaluate the associations of residential greenness with full-spectrum lung function indicators and prevalence of chronic obstructive pulmonary disease (COPD).
Methods: This nationwide cross-sectional survey included 50,991 participants from the China Pulmonary Health study.