A computational and multi-brain signature for aberrant social coordination in schizophrenia.

Social functioning impairment is a core symptom of schizophrenia (SCZ). Yet, the computational and neural mechanisms of social coordination in SCZ under real-time and naturalistic settings are poorly understood. Here, we instructed patients with SCZ to coordinate with a healthy control (HC) in a joint finger-tapping task, during which their brain activity was measured by functional near-infrared spectroscopy simultaneously.

Impact of second-generation antipsychotics monotherapy or combined therapy in cytokine, lymphocyte subtype, and thyroid antibodies for schizophrenia: a retrospective study.

Background: Schizophrenia (SCZ) shares high clinical relevance with the immune system, and the potential interactions of psychopharmacological drugs with the immune system are still an overlooked area. Here, we aimed to identify whether the second-generation antipsychotics (SGA) monotherapy or combined therapy of SGA with other psychiatric medications influence the routine blood immunity biomarkers of patients with SCZ.

Methods: Medical records of inpatients with SCZ from January 2019 to June 2023 were retrospectively screened from June 2023 to August 2023.

The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation.

Elucidating the neural basis of fear allows for more effective treatments for maladaptive fear often observed in psychiatric disorders. Although the basal forebrain (BF) has an essential role in fear learning, its function in fear expression and the underlying neuronal and circuit substrates are much less understood. Here we report that BF glutamatergic neurons are robustly activated by social stimulus following social fear conditioning in male mice.

The interpersonal computational psychiatry of social coordination in schizophrenia.

Impairments in social coordination form a core dimension of various psychiatric disorders, including schizophrenia. Advances in interpersonal and computational psychiatry support a major change in studying social coordination in schizophrenia. Although these developments provided novel perspectives to study how interpersonal activities shape coordination and to examine computational mechanisms, direct attempts to integrate the two methodologies have been sparse.

[Resilience in cancer patients and related nursing interventions].

Cancer is a critical health problem in Taiwan. The range of physical, psychological, social, and existential stressors associated with cancer diagnosis and treatment can cause significant distress in cancer patients and survivors. The focus of cancer research has broadened in the past decade from the disease itself to factors that can have a positive influence on the health and life quality of cancer patients.