OpenProt 2.0 builds a path to the functional characterization of alternative proteins.

The OpenProt proteogenomic resource (https://www.openprot.org/) provides users with a complete and freely accessible set of non-canonical or alternative open reading frames (AltORFs) within the transcriptome of various species, as well as functional annotations of the corresponding protein sequences not found in standard databases.

Molecular Detection of Helicobacter pylori and its Antimicrobial Resistance in Brazzaville, Congo.

Back Ground: Helicobacter pylori infection is involved in several gastroduodenal diseases which can be cured by antimicrobial treatment. The aim of this study was to determine the prevalence of H. pylori infection and its bacterial resistance to clarithromycin, fluoroquinolones, and tetracycline in Brazzaville, Congo, by using molecular methods.

[Septic arthritis in tropical environment. 176 cases report in Brazzaville].

Objective: We report epidemiologic, clinic, para clinic, therapeutic and evolution aspects of septic arthritis in African tropical zone.

Material And Methods: Retrospective survey in rheumatologic department of Brazzaville University Teaching Hospital over a period of 15 years and 6 months carrying on 176 septic arthritis observed among 3042 hospitalized patients.

Results: 70 men (39.

[Human immunodeficiency virus associated arthritis in Congo Brazzaville].

Objective: The authors report epidemiologic, clinical, para clinical, and evolutive aspects of arthritis related to HIV in an AIDS endemic country.

Material And Methods: A retrospective study was made in the rheumatology department of the Brazzaville University Teaching Hospital during 15 years and 6 months, on 3.042 in-patients among whom 306 (10%) were positive for HIV, 220 (7.

[An immunisation coverage survey in the Kouilou area of Congo-Brazzaville].

An internal review of the expanded program of immunisation undertaken on the basis of daily data collected over the past five years from 1993 to 1997 in the region of Kouilou revealed a weak coverage level for all the antigens, associated with a strong dropout rate. In August 1999, a vaccination coverage survey was carried out on three strata of the Kouilou area in order to determine the proportion of children vaccinated by antigens. The method used is that of sampling clusters.

[Course of pulmonary tuberculosis in diabetics].

This retrospective study on the impact of diabetes on the course of pulmonary tuberculosis was conducted in 32 diabetic patients with tuberculosis treated at the Brazzaville University Hospital between January 1994 and December 1998. This group was compared with a control group of 100 non-diabetic patients with tuberculosis. HIV-positive patients were excluded from the study.

[Survey of measles vaccine coverage in Brazzaville].

Measles is an infectious disease that continues to be a significant cause of morbidity and mortality among children in Brazzaville. A measles vaccination coverage survey was conducted for children aged 9 to 23 months. A standard EPI cluster sample was applied in two areas: urban and peri-urban.

[Missed vaccination opportunities in Brazzaville].

In order to assess the magnitude of missed immunisation opportunities, a study was carried out at ten randomly selected health centres in Brazzaville (Congo). A survey based on interviews at discharge was conducted with 306 mothers or caretakers of children aged under 2 years. The overall rate of missed immunization opportunities was 12.

[Clinical, epidemiological and therapeutic aspects of purulent meningitis in the adult. Apropos of 74 cases treated at CHU of Brazzaville (Congo)].

During 2 years and 9 months, 74 patients were hospitalized to purulent meningitis at the Hospital of Brazzaville and 33 were bacteriologically confirmed. The pneumococcus was responsible in 24 cases (33.4%).

[Prospective study of rheumatic manifestations in human immunodeficiency virus infection. Apropos of 26 cases in Congo].

A 12-month prospective study of the osteo-articular complaints in HIV infected patients was carried out in the Department of Rheumatology, Brazzaville, Congo. Positivity of the HIV serology was systematically researched. And so the authors have observed rheumatic disorders in 26 patients, 12 males, 14 females, with a mean age of 36 years (ranged from 13 to 78).

[Virological and bacteriological study of materno-fetal infections in Brazzaville].

Serological study of serum samples taken from pregnant women and umbilical cord and bacteriological study of vaginal secretions samples and cerebrospinal fluid (CSF) showed in mothers: T. pallidum antibody (Tp ab) 9%, Rubella virus antibody (Ru ab) 85%; HBs Ag 16%, HIV antibody (HIV ab) 4%. Microbe culture showed: S.

[Carrier state for HBs antigen and HBc antibody in Brazzaville (congo): sero-epidemiological study in the hospital and non-hospital environment].

In Brazzaville (Congo), the prevalence of chronic carriage of HBs Ag (7.31%) we observed, is similar to the ones previously reported in 1981, 1982 and 1988. The sero-prevalence of anti-HBc is 67.

[Seroconversion following immunization with a plasma-derived vaccine against hepatitis B: study of a 3-injection protocol (0, 1, 6 months) in Brazzaville (Congo)].

The aim was to study the immunogenicity of a plasma-derived vaccine against Hepatitis B Virus administrated in 3 injections at month 0-1-6. Only subjects without HBs Ag and anti-HBc were vaccinated. The seroconversion rates were 79.

[Carriers of HBs antigen, anti-HIV antibodies and their association with blood donors in Brazzaville].

Serum samples taken from 6,624 blood donors since 1984 to 1987, were tested for Hepatitis B virus surface antigen (HBs Ag) using a microhemagglutination assay and for anti-HIV antibodies by ELISA test. The mean carrier state of HBs Ag was 10.68% and that of anti-HIV antibodies was 6.

[Escherichia coli diarrhea of children and adults at the Brazzaville General Hospital].

The high number of the strains of Escherichia coli (E. coli) isolated from faeces, demonstrated that this bacteria takes the first place in diarrhoea. These isolations had the same frequency all the year long.

[Role of interhuman infection during the cholera epidemic in the People's Republic of the Congo (1978-1979)].

The authors make an epidemiologic analysis of the first cholera cases notified by the Congo in 1978 and 1979. Contrary to the explosive cholera, experiences by Burundi and Zaïre during the same period, the cholera, in the Congo, had a very subtle propagation, with the well-know "iceberg" phenomena. Human contacts were very important in the transmission of the disease.

[Preliminary surveys on Neisseria gonorrhoeae infections in Brazzaville. Incidence and drug sensitivity].

It is well known that gonococcal infections represent serious problems through the world. In developing countries, these problems are very intricate. It is time to get into working order.

[The sulfamethoxazole-trimethoprim combination 1st survey into its in vitro activity in brazzaville, Congo Results of 780 bacterial strains isolated at the National Laboratory and the General Hospital in a single year].

The combination of SMZ-TMP has recently been introduced in Congo. This year (1978), it is very used by many Physicians. To help the congolese Physicians working without antibiogram frequently, we have tested 780 strains from August 1977 to August 78.

[Hemolytic disease of African newborn. Results of a survey conducted at Brazzaville (Congo)].

The authors report one study on the haemolytic disease of african newborn made in Brazzaville (Congo). As in the most of the african countries this disease is not very frequent and it is not very severe. Two cases have been found in two twins, born after the nineth pregnancy.