A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis.

The dynamic interaction between central respiratory chemoreceptors and the respiratory central pattern generator constitutes a critical homeostatic axis for stabilizing breathing rhythm and pattern, yet its circuit-level organization remains poorly characterized. Here, the functional connectivity between two key medullary hubs: the nucleus tractus solitarius (NTS) and the preBötzinger complex (preBötC) are systematically investigated. These findings delineate a medullary network primarily comprising Phox2b-expressing NTS neurons (NTS), GABAergic NTS neurons (NTS), and somatostatin (SST)-expressing preBötC neurons (preBötC).

PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial.

Alpha-fetoprotein-producing gastric or gastro-esophageal junction (AFP-G/GEJ) cancer, a rare gastric cancer subtype, exhibits increased angiogenesis and more immunosuppression than non-AFP-G/GEJ cancer. The potential benefits of anti-angiogenic agents and immunotherapy for this specific subtype remain unknown. This multi-center, single-arm, phase 2 trial (ClinicalTrials.

Comparative analysis of the mitochondrial genomes of the soft-shelled turtles Palea steindachneri and Pelodiscus axenaria and phylogenetic implications for Trionychia.

Soft-shelled turtles, or Trionychia, are an enigmatic and fascinating group due to their specific morphological features and ecological adaptations. Based on mitochondrial DNA (mtDNA) and/or nuclear markers, previous studies showed the incongruent phylogenetic topologies within Trionychia (e.g.

Scene-Adaptive Loader Trajectory Planning and Tracking Control.

Wheel loaders play a crucial role in daily production and transportation. With the rapid development of intelligence in passenger vehicles, freeing loader operators from high-risk and repetitive tasks has become a pressing issue. This paper presents a novel and efficient path planning and tracking framework tailored to the unique body structure and specific operating environment of loaders.

Identification and validation of diagnostic genes and in insomnia-associated autoimmune uveitis.

Objective: Insomnia is increasingly recognized as a significant factor in the development of various autoimmune diseases, including autoimmune uveitis (AU). We investigated insomnia-associated genes that may contribute to AU pathogenesis and sought to identify potential biomarkers for insomnia-associated AU.

Methods: Microarray data related to insomnia and AU were downloaded from the Gene Expression Omnibus (GEO) database and analyzed.

Perioperative or postoperative adjuvant oxaliplatin with S-1 versus adjuvant oxaliplatin with capecitabine in patients with locally advanced gastric or gastro-oesophageal junction adenocarcinoma undergoing D2 gastrectomy (RESOLVE): final report of a randomised, open-label, phase 3 trial.

Background: The multicentre RESOLVE trial examined the efficacy of perioperative and postoperative S-1 and oxaliplatin (SOX) compared with postoperative capecitabine and oxaliplatin (CapOx) in gastric or gastro-oesophageal junction cancer. Initial analyses did not encompass overall survival owing to the immature data. This paper provides an updated analysis of the survival data from the RESOLVE trial.

Atomic Layer Deposition Stabilizes Nanocrystals, Enabling Reliably High-Performance Quantum Dot LEDs.

Quantum dot light-emitting diodes (QD-LEDs) with stable high efficiencies are crucial for next-generation displays. However, uncontrollable aging, where efficiency initially increases during storage (positive aging) but is entirely lost upon extended aging (negative aging), hinders further device development. It is uncovered that it is chemical changes to nanocrystal (NC)-based electron transport layer (ETL) that give rise to positive aging, their drift in structure and morphology leading to transiently improved charge injection balance.

Effect of steady-state thermal blooming on partially coherent radially polarized beams propagating in the atmosphere.

We undertake a computational study of the steady-state thermal blooming effect on a special class of partially coherent vector beams, called partially coherent radially polarized (PCRP) beams, propagating through the atmosphere. A computational propagation model that is based on a multi-phase screen method is established to simulate partially coherent vector beams. With the use of this model, the propagation properties of PCRP beams with different initial powers and spatial coherence widths are studied in detail, including average intensity distribution, r.

Phylogeography and genetic diversity of Ulmus elongata (Ulmaceae), a Tertiary relict tree with extremely small populations (PSESP).

Background: Assessing the current status and identifying the mechanisms threatening endangered plants are significant challenges and fundamental to biodiversity conservation, particularly for protecting Tertiary relict trees and plant species with extremely small populations (PSESP). Ulmus elongata (Ulmus, Ulmaceae) with high values for the ornamental application, is a Tertiary relict tree species and one of the members from PSESP in China. Currently, the wild populations of U.

SREBF1 facilitates pathological retinal neovascularization by reprogramming the fatty acid metabolism of endothelial cells.

Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder that critically affects the visual development of premature infants, potentially leading to irreversible vision loss or even blindness. Despite its significance, the underlying mechanisms of this disease remain insufficiently understood. In this study, we utilized the oxygen-induced retinopathy (OIR) mouse model and conducted endothelial functional assays to explore the role of Sterol Regulatory Element-Binding Protein 1 (SREBF1) in ROP pathogenesis.

Liquid bidentate ligand for full ligand coverage towards efficient near-infrared perovskite quantum dot LEDs.

Perovskite quantum dots (PQDs) show promise in light-emitting diodes (LEDs). However, near-infrared (NIR) LEDs employing PQDs exhibit inferior external quantum efficiency related to the PQD emitting in the visible range. One fundamental issue arises from the PQDs dynamic surface: the ligand loss and ions migration to the interfacial sites serve as quenching centers, resulting in trap-assisted recombination and carrier loss.

Identification of immunostimulatory activities and active compounds from sequentially extracted fractions of rhizosphere fungal fermentation broth of Koidz. rhizomes.

Introduction: Pharmacological studies have shown that the rhizome of Atractylodes macrocephala Koidz. (Compositae), commonly known as atractylodes macrocephala rhizome (AMR), can modulate immunity. Nevertheless, its resources have been largely depleted, and the pharmacological activity of artificial AMR is relatively modest.

Downregulation of serum miR-30c-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients.

Background & Objective: Timely intervention for Acute coronary syndrome (ACS) could effectively reduce the mortality rate of ACS patients. This study aimed to investigate the clinical significance of miR-30c-5p for ACS and to provide a convenient biomarker for diagnosing of ACS.

Methods: Baseline information was collected from a total of 173 subjects (98 ACS subjects and 65 healthy subjects).

Analysis of lung microbiota in pediatric pneumonia patients using BALF metagenomic next-generation sequencing: A retrospective observational study.

The contribution of the lung microbiota to pneumonia in children of varying severity remains poorly understood. This study utilized metagenomic next-generation sequencing (mNGS) technology to elucidate the characteristics of lung microbiota and their association with disease severity. This retrospective study analyzed bronchoalveolar lavage fluid (BALF) mNGS data of 92 children diagnosed with pneumonia between January 2021 and July 2022.

The potential of melatonin and its crosstalk with other hormones in the fight against stress.

Climate change not only leads to high temperatures, droughts, floods, storms and declining soil quality, but it also affects the spread and mutation of pests and diseases, which directly influences plant growth and constitutes a new challenge to food security. Numerous hormones like auxin, ethylene and melatonin, regulate plant growth and development as well as their resistance to environmental stresses. To mitigate the impact of diverse biotic and abiotic stressors on crops, single or multiple phytohormones in combination have been applied.

Ensemble learning-assisted quantitative identifying influencing factors of cadmium and arsenic concentration in rice grain based multiplexed data.

Rapid and accurate prediction of rice Cd (rCd) and rice As (rAs) bioaccumulation are important for assessing the safe utilization of rice. Currently, there is lack of comprehensive and systematic exploration of the factors of rCd and rAs. Herein, ensemble learning (EL) was first used to analysis the 23 factors in 8 categories (heavy metal pollution characteristics, soil properties, geographical characteristics, meteorological factors, socio-economic factors, environmental factors, rice type, and nutrient element) in typical regions of China based on the results of 193 research papers from 2000 to 2024 in Web of Science database.

The impact of angiotensin-receptor neprilysin inhibitors on cardiovascular events and solute transport function in peritoneal dialysis patients: a multicenter retrospective controlled study.

Background: Whether angiotensin receptor-neprilysin inhibitor (ARNI) can reduce the incidence of cardiovascular events and improve peritoneal function in peritoneal dialysis (PD) patients remains unclear. Thus, this study aims to clarify the role of ARNI in PD patients.

Methods: This was a multicenter retrospective study.

Simulation, prediction and optimization for synthesis and heavy metals adsorption of schwertmannite by machine learning.

Due to its sea urchin-like structure, Schwertmannite is commonly applied for heavy metals (HMs) pollutant adsorption. The adsorption influence parameters of Schwertmannite are numerous, the traditional experimental enumeration is powerless. In recent years, machine learning (ML) has been gradually employed for adsorbent materials, but there is no comprehensive research on the Schwertmannite adsorbent.

A review of hydroxyapatite synthesis for heavy metal adsorption assisted by machine learning.

Heavy metals (HMs) represent a persistent and significant threat to aquatic ecosystems. Hydroxyapatite (HAp) has emerged as a utilized material in the remediation of environmental HMs, owing to its exceptionally high porosity, expansive surface area, and the presence of three-dimensional ordered channels. An in-depth study of the synthesis strategy of HAp and its adsorption properties can help reduce the cost of remediating HMs in aquatic environments and alleviate the water shortage.

LDHA exacerbates myocardial ischemia-reperfusion injury through inducing NLRP3 lactylation.

Myocardial ischemia-reperfusion (I/R) injury caused by revascularization treatment is the leading cause of cardiac damage aggravation in ischemic heart disease. Increasing evidence has unraveled the crucial role of pyroptosis in myocardial I/R injury. Of note, lactylation has been validated to be participated in modulating pyroptosis.

Nanoplastics Distribution during Ice Formation: Insights into Natural Surface Water Freezing Conditions.

The migration characteristics of nanoplastics (NPs) in the natural freezing process are complex and have attracted increasing attention in simulating natural freezing in recent years. However, simulated freezing conditions often fall short of replicating natural freezing processes, and studies on the vertical distribution of NPs remain inadequate. This study established a more realistic simulation of the natural freezing process in surface water by controlling both the air temperature () and the water temperature ().