Solvent Effect on Dative and Ionic Bond Strengths: A Unified Theory from Potential Analysis and Valence-Bond Computations.

Solvent molecules interact with a solute through various intermolecular forces. Here we employed a potential energy surface (PES) analysis to interpret the solvent-induced variations in the strengths of dative (MeNBH) and ionic (LiCl) bonds, which possess both ionic and covalent (neutral) characteristics. The change of a bond is driven by the gradient (force) of the solvent-solute interaction energy with respect to the focused bond length.

LncRNA GHET1 promotes esophageal squamous cell carcinoma cells proliferation and invasion via induction of EMT.

Background: Recent studies have shown that long noncoding RNA (lncRNA) gastric carcinoma highly expressed transcript 1 (GHET1) was involved in the progression of tumors. However, the role of GHET1 in esophageal squamous cell carcinoma (ESCC) remains unclear.

Methods: The expression of lncRNA GHET1 was examined in 55 paired ESCC tissues and adjacent nontumor tissues.

MiRNA-155 promotes proliferation by targeting caudal-type homeobox 1 (CDX1) in glioma cells.

MicroRNAs (miRNAs) play important roles in the tumorigenesis of glioma. Recent studies showed that miR-155 expression was increased in types of cancer, including glioma. However, the underlying mechanism of miR-155 on glioma is still unclear.

Association of insulin-like growth factor I gene polymorphisms with the risk of osteoporosis in a Chinese population.

Osteoporosis is a systemic metabolic and serious skeletal disease commonly observed among the elderly. Insulin-like growth factors (IGFs) are critical regulators for bone cell function. We estimated the role of IGF-I rs35767, rs2288377 and rs5742612 polymorphisms in the susceptibility to osteoporosis in a population of China, and assessed gene-environment interactions.