The pigment epithelium-derived factor (PEDF): an important potential therapeutic agent for infantile hemangioma.

In previous studies, the expression and the role of proangiogenic factors in infantile hemangiomas have been well studied. However, the role of angiogenic inhibitors has been revealed rarely. The expression of PEDF, as the strongest and safe endogenous inhibitor, is still unrecognized until the current study.

[Combining eyebrow and inferior palpebral margin incision for the facial rejuvenation in the upper eyelid and midface region].

Objective: To investigate a simple, minimally invasive and effective operative method for the facial rejuvenation in the upper eyelid and midface region.

Methods: Blepharoplasty was combined with suspending orbicularis oculi muscle flap and fixing it on the periosteum underneath the eyebrow through eyebrow incision. Meanwhile, for midface rejuvenation, inferior palpebral margin incision was performed and prezygomatic interspace was separated completely under the orbicularis oculi muscle.

[Prospective and comparative study of the double eyelid blepharoplasty with central minimal incision and with three minimal incisions].

Objective: To compare the clinical effect of the double eyelid blepharoplasty with central minimal incision and with three minimal incisions. Methods: From Jul. 2010 to May 2012, 268 cases (Group A) received double eyelid blepharoplasty with central minimal incision, while 102 cases (Group B) underwent double eyelid blepharoplasty with three minimal incisions.

[Preliminary clinical study on the treatment of severe infantile hemangioma with high-dose propranolol in China].

Objective: To investigate the clinical results of the treatment of severe infantile hemangioma with high-dose propranolol in Chinese.

Methods: 56 cases with severe infantile hemangioma were treated with propranolol. Clinical evaluation, electrocardiography, and experimental examination of liver function and heart function were performed before treatment.

[A three-dimension in vitro model for angiogenesis of hemangioma].

Objective: To create a three dimension (3D) in vitro model for angiogenesis of hemangioma.

Method: The fragment of hemangioma specimen was embedded in fibrin gel to set up the three-dimension (3D) in vitro model for angiogenesis of hemangioma.

Result: In the model, microvessels grew out from the tissue fragments at the 2nd to 3rd day after culture, and at the 8th to 9th day a compact network of microvessels come into being, then tending to be stationary.