[Method of manual-physical correction in the treatment of hypertensive disease and normalization of psychoneurological status in patients with degenerative-dystrophic processes of the musculoskeletal system].

There are some non-communicable diseases (NCD) associated with arterial hypertension (AHT) that are cured after recovery from AHT. Recently confirmed the theory of centralized aerobic-anaerobic energy balance compensation (TCAAEBC) originated some NCDs with the obstructions of arterial blood flow access to the rhomboid fossa. For some sergeants, this has already been demonstrated.

Clinical, Laboratory, Molecular, and Reproductive Aspects of Combined Deficiency of Factors V and VIII.

Congenital combined deficiency of factor V (FV) and factor VIII (FVIII; F5F8D, OMIM 227300) is a rare hereditary coagulopathy and accounts for approximately 3% of cases of rare coagulation disorders. The prevalence of this disease in the general population is estimated to be 1:1,000,000 and is significantly higher in regions where consanguineous marriages are permitted, such as the Mideast and South Asia. The disease has an autosomal recessive mode of inheritance and therefore occurs with an equal incidence among males and females.

[Efficacy and safety of levilimab in the treatment of patients with rheumatoid arthritis].

Aim: Evaluation in real clinical practice of the effectiveness and safety of levilimab therapy in patients with highly and moderately active rheumatoid arthritis (RA).

Materials And Methods: A prospective observational study (6 months) involving 35 patients with RA (29 women and 6 men, mean age 53.17±13.

[Physical methods of correction of arterial hypertension: modern concepts. (A literature review)].

Arterial hypertension is a major risk factor for cardiovascular disease, affecting a large proportion of the population worldwide. The study of the listed literature made it possible to assess the effectiveness and necessity of physical exercise in the treatment of hypertension syndrome, including various types of exercise, intensity, duration, and frequency, since drug treatment is not enough for successful therapy. To prevent and treat hypertension, a comprehensive approach is required, including aerobic exercise, which will lower blood pressure by dilating blood vessels.

Salt concentration in substrate modulates the composition of bacterial and yeast microbiomes of .

Microbiomes influence the physiology and behavior of multicellular organisms and contribute to their adaptation to changing environmental conditions. However, yeast and bacterial microbiota have usually been studied separately; therefore, the interaction between bacterial and yeast communities in the gut of () is often overlooked. In this study, we investigate the correlation between bacterial and yeast communities in the gut of .

Crystal structure and Hirshfeld surface analysis of ()-4-({[2-(benzo[]thio-phen-3-yl)cyclo-pent-1-en-1-yl]meth-yl}(phen-yl)amino)-4-oxobut-2-enoic acid.

In the title compound, CHNOS, the cyclopentene ring adopts an envelope conformation. In the crystal, mol-ecules are linked by C-H⋯π inter-actions, forming ribbons along the axis. Inter-molecular C-H⋯O hydrogen bonds connect these ribbons to each other, forming layers parallel to the (01) plane.

Properties of chromatographic columns prepared on the basis of poly(1-trimethylsilyl-1-propyne) modified with organic bases.

This article describes the effect of modification with organic bases such as uracil (U) and polyethyleneimine (PEI) on the adsorption and chromatographic properties of poly(1-trimethylsilyl-1-propyne) (PTMSP) used as a stationary phase (SP) in packed and capillary columns. It was shown that the sorbents prepared on the basis of diatomite Chromosorb P NAW support and successively modified with 9 wt.% PTMSP and 1 wt.

[Theory of centralized aerobic-anaerobic energy balance compensation and non-pharmaceutical treatment methods of arterial hypertension].

Several chronic non-communicable diseases are associated with arterial hypertension and are closely related to increased blood pressure. The theory of centralized aerobic-anaerobic energy balance compensation (TCAAEBC) was formulated in connection with the above-mentioned processes. This theory, including the hypothesis of the «egoistic brain», is a broader concept.

[Efficacy of manual correction of cervical spine osteochondrosis in the treatment of arterial hypertension syndrome and prediabetes].

Unlabelled: Cardiovascular diseases and diabetes mellitus, debuting as arterial hypertension (AH) syndrome and prediabetes, are common types of chronic non-communicable processes, that are the leading cause of death in the world. The main treatment method for above mentioned disorders, according to the current guidelines, is pharmacotherapy. However, it is possible to effectively apply non-pharmacological correction methods, aimed at the probable etiological factor and inversive mechanism involved in AH maintenance, in the early stages when no permanent changes are maintaining a high level of blood hypertension (BH) and glycemia.

Studying the Structure and Properties of Epoxy Composites Modified by Original and Functionalized with Hexamethylenediamine by Electrochemically Synthesized Graphene Oxide.

In this study, we used multilayer graphene oxide (GO) obtained by anodic oxidation of graphite powder in 83% sulfuric acid. The modification of GO was carried out by its interaction with hexamethylenediamine (HMDA) according to the mechanism of nucleophilic substitution between the amino group of HMDA (HMDA) and the epoxy groups of GO, accompanied by partial reduction of multilayer GO and an increase in the deformation of the carbon layers. The structure and properties of modified HMDA-GO were characterized using research methods such as scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy and Raman spectroscopy.

Application of the intramolecular Diels-Alder vinylarene (IMDAV) reaction for the synthesis of benzo-, carbocyclo-, thienothiopheneisoindolecarboxylic acids and its limitations.

Thienylallylamines, readily accessible from the corresponding thienyl aldehydes, react with maleic and trifluoromethylmaleic anhydrides leading to the formation of acids with a thieno[2,3-]isoindole core. The reaction sequence involves two successive steps: acylation of the nitrogen atom of the initial allylamine and the intramolecular Diels-Alder vinylarene (IMDAV) reaction. The scope and limitations of the proposed method were thoroughly investigated.

Crystal structure and Hirshfeld surface analysis of 10-hy-droxy-2-(4-meth-oxy-phen-yl)-3-oxo-2,3,3a,4,10,10a-hexa-hydro-1-9-thia-2-aza-cyclo-penta-[]fluorene-4-carb-oxy-lic acid dimethyl sulfoxide- monosolvate.

In the title compound, CHNOS·CDOS, the central six-membered ring has a slightly distorted boat conformation, while the fused pyrrolidine ring adopts an envelope conformation. These conformations are stabilized by O-H⋯O hydrogen bonds between the main compound and solvent mol-ecules. In addition, intra-molecular C-H⋯O hydrogen bonds in the main mol-ecule form two (6) rings.

The phenotypic and genetic features of arrhythmogenic cardiomyopathy in the pediatric population.

Introduction: The present study aimed to describe the phenotypic features and genetic spectrum of arrhythmogenic cardiomyopathy (ACM) presented in childhood and test the validity of different diagnostic approaches using Task Force Criteria 2010 (TFC) and recently proposed Padua criteria.

Patients And Methods: Thirteen patients (mean age at diagnosis 13.6 ± 3.

Crystal structure and Hirshfeld surface analysis of 4-cyano--[(4-cyano-phen-yl)sulfon-yl]--[2-(5-methyl-furan-2-yl)phen-yl]benzene-sulfonamide.

In the title compound, CHNOS, intra-molecular π-π inter-actions [centroid-to-centroid distance = 3.5640 (9) Å] are observed between the furan and benzene rings of the 4-cyano-phenyl group. In the crystal, mol-ecules are connected C-H⋯O and C-H⋯N hydrogen bonds, forming layers parallel to the (100) plane.

Relationship between atmospheric pollution and polycyclic aromatic hydrocarbons in fresh snow during heavy pollution episodes in a cold city, northeast China.

Air quality index (AQI) and air pollutants during two typical pollution episodes, and polycyclic aromatic hydrocarbons (PAHs) in fresh snow after each episode in the winter 2019 across Harbin City in northeast China were investigated to explore the co-environmental behaviors. Significantly greater values of AQI and PAHs were found in the more serious atmospheric pollution episode (episode Ⅱ), demonstrating that PAHs in fresh snow is a robust indicator. PM was the primary air pollutant in both episodes based on PM/PM ratios, which might be attributed to fine particulate converted from gas-to-particle process.

Spatiotemporal characteristics and socioeconomic factors of PM heterogeneity in mainland China during the COVID-19 epidemic.

Spatiotemporal variation of PM in 2018 and 2020 were compared to analyze the impacts of COVID-19, the spatial heterogeneity of PM, and meteorological and socioeconomic impacts of PM concentrations heterogeneity in China in 2020 were investigated. The results showed that the annual average PM concentration in 2020 was 32.73 μg/m existing a U-shaped variation pattern, which has decreased by 6.

Motus Vita Est: Fruit Flies Need to Be More Active and Sleep Less to Adapt to Either a Longer or Harder Life.

Background: Activity plays a very important role in keeping bodies strong and healthy, slowing senescence, and decreasing morbidity and mortality. models of evolution under various selective pressures can be used to examine whether increased activity and decreased sleep duration are associated with the adaptation of this nonhuman species to longer or harder lives.

Methods: For several years, descendants of wild flies were reared in a laboratory without and with selection pressure.

Porous-layer columns with a poly(1-trimethylsilyl-1-propyne) stationary phase for determining of catalytic reactions components, natural gas and its processed products.

The presented review is devoted to methods for determining the component composition of the studied catalytic reactions, natural gas and its processed products using gas chromatography columns prepared on the basis of poly(1-trimethylsilyl-1-propyne) polymer (PTMSP). Methods of polymer modification are proposed in order to change the polarity and selectivity of separation of compounds of different chemical nature. The influence of the film thickness of the PTMSP stationary phase on the separation parameters and the loading capacity of the columns used is noted.

Spectrum of Causative Mutations in Patients with Hemophilia A in Russia.

Hemophilia A (HA) is one of the most widespread, X-linked, inherited bleeding disorders, which results from defects in the gene. Nowadays, more than 3500 different pathogenic variants leading to HA have been described. Mutation analysis in HA is essential for accurate genetic counseling of patients and their relatives.

Factor XII deficiency: a clinical and molecular genetic study.

Factor XII deficiency is a rare inherited disorder caused by clotting factor XII (FXII, F12) deficiency. It is often asymptomatic but can have both thrombotic and haemorrhagic symptoms. The aim of this study was to describe the spectrum of F12 gene mutations in a Russian population and learn more about the relationship between F12 variants and clinical phenotypes.

Comparative study of the serum hepcidin level of patients with pneumonia in COVID-19 and Pneumocystis pneumonia.

In the context of a pandemic caused by the SARS-CoV-2 virus, for a patient with respiratory symptoms and bilateral lung damage, COVID-19 becomes the first disease in the differential diagnostic search. Pneumonia in COVID-19 shares many characteristics with Pneumocystis pneumonia. One of the possible markers of the severe course of COVID-19 is hepcidin, a peptide hormone that negatively regulates iron metabolism.

New heteroanalogs of tricyclic ascidian alkaloids: synthesis and biological activity.

Heteroanalogs of ascidian alkaloids have been synthesized, and for the first time 10 different types of saturated carbo- and heteroannulated pyridones have been obtained. A new method for the formation of decahydro[1,3]oxazolo[2,3-]quinoline and octahydro-5-cyclopenta[][1,3]oxazolo[3,2-]pyridine was proposed. The synthesis of these heterocycles is based on the three-component cyclization of trifluoroacetoacetic ester and cycloketones with 1,2- and 1,3-dinucleophiles.

[Five year experience in ibrutinib therapy for relapsed and refractory mantle cell lymphoma in real world Russian clinical practice].

Background: Mantle cell lymphoma (MCL) is a rare and clinically aggressive lymphoma subtype. Current approaches have greatly improved patients outcomes, but relapse is inevitable. In phase IIIII clinical trials, ibrutinib has shown significant activity in patients with relapsed or refractory (R/R) MCL.

Case Reports: Emery-Dreifuss Muscular Dystrophy Presenting as a Heart Rhythm Disorders in Children.

Emery-Dreifuss muscular dystrophy (EDMD) is inherited muscle dystrophy often accompanied by cardiac abnormalities in the form of supraventricular arrhythmias, conduction defects and sinus node dysfunction. Cardiac phenotype typically arises years after skeletal muscle presentation, though, could be severe and life-threatening. The defined clinical manifestation with joint contractures, progressive muscle weakness and atrophy, as well as cardiac symptoms are observed by the third decade of life.

[Iron metabolism and indicators reflecting its changes in pulmonary tuberculosis (literature review).].

Iron is an essential element for human and bacteria, including mycobacterium tuberculosis. Over review includesthe literature on the problem of iron metabolism in patients with tuberculosis and with comorbid pathology HIV infection and tuberculosis. The literature was searched for when writing this review using the RSCI, CyberLeninka, Scopus, Web of Science, MedLine, PubMed databases using the following keywords: iron, ferritin, hepsidin, lactoferrin, tuberculosis, pneumonia, HIV infection.