Publications by authors named "Yakirevitch A"

Purpose: To assess a novel Virtual Reality (VR) tool designed to enhance understanding of the nasal anatomy in patients eligible for DCR surgery.

Methods: Preoperative Computed Tomography (CT) scans of the orbit were obtained and loaded as DICOM (Digital Imaging and Communications in Medicine) files onto the D2P software (3D Systems Inc. Littleton, CO) for tissue segmentation and 3D model preparation.

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Background: diabetic complications and olfactory dysfunction (OD) in patients with type 2 diabetes mellitus (T2DM) seem related. This study aims to evaluate the prevalence of OD in T2DM patients and to analyze its relationship with diabetic complications.

Methods: 130 T2DM patients and 100 comparable controls were enrolled.

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Purpose: To provide real-life data on azole treatment outcomes and the role of surgery in the current management of invasive fungal rhinosinusitis complicated by orbitocranial fungal infection (OCFI).

Methods: Data was collected retrospectively from a chart review from four participating centers and a systematic literature review. The study group included patients with OCFI treated with azole antifungals.

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Background: Benign paroxysmal positional vertigo (BPPV) is effectively treated with a variety of repositioning maneuvers but one-third to one-half of patients experience recurrence, usually within 2 years after the first attack.

Objectives: The aim of this study was to investigate possible prevention of recurrent BPPV by sleep habit modification.

Methods: Patients diagnosed with posterior semicircular canal BPPV (p-BPPV) were asked their preferred lying side during nocturnal sleep.

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Purpose: This study examines the impact of concomitant mucosal inflammation on clinical manifestations and long-term outcomes of Inverted Papilloma (IP).

Methods: This retrospective cohort study was conducted in five tertiary medical centers. The included patients underwent an attachment-oriented surgical resection for IP with a minimum follow-up of 3 years.

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Objective: This study aimed to examine the association between nasal septal deviation and antrochoanal polyp.

Methods: This was a retrospective review of medical records and imaging of patients who underwent endoscopic sino-nasal surgery for antrochoanal polyp.

Results: Forty-eight patients operated on for antrochoanal polyp between 2009 and 2019 were eligible for the study.

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Article Synopsis
  • - SARS-CoV-2 Omicron variant shows reduced clinical severity, prompting research into how its interactions with the respiratory tract affect this difference in pathogenicity.
  • - In lab tests with human nasal and lung tissues, Omicron's replication in lung tissues is much more restricted compared to Delta and earlier variants, while remaining similar in nasal tissues.
  • - Omicron triggers a stronger antiviral interferon response in lung tissues than Delta and earlier variants, suggesting that this enhanced immune response contributes to its lower severity; blocking this immune response can allow greater replication of Omicron in lungs.
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Objective: The transnasal endoscopic approach may provide better visualisation and a safer approach to the orbital apex. This study presents a case series of orbital apex lesions managed by this approach.

Method: This study was an eight-year retrospective analysis of seven patients who were operated on for orbital apex lesions in two tertiary medical centres.

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Objective: To study the applicability of transnasal echography for the internal carotid artery (ICA) imaging during endoscopic procedures, primarily nasopharyngectomy.

Study Design: Non-randomized controlled cohort.

Methods: The tip of a pediatric transducer for transesophageal echography was inserted into each nostril under endoscopic control and placed in the ipsilateral Rosenmuller's fossa.

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Purpose: To explore the association between intraoperative surgical margin sampling by the frozen sections and recurrence in inverted papilloma surgery.

Methods: A multicenter, retrospective study of patients who underwent attachment-oriented IP resection in four tertiary care medical centers with a minimal follow-up of 36 months.

Results: The study included 220 surgeries with a mean follow-up period of 49 months (range 36-204).

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Article Synopsis
  • The nasal mucosa is the main entry point for respiratory viruses like SARS-CoV-2, but its early immune responses during infection have been largely overlooked.
  • Research used human nasal and lung tissues to analyze how these sites respond to SARS-CoV-2 compared to influenza, revealing that the nasal mucosa mounts a strong antiviral response while lung tissues show a much weaker reaction.
  • These findings indicate that targeting the nasal mucosa could be crucial for early intervention during SARS-CoV-2 infection, potentially preventing severe lung damage seen in advanced COVID-19 cases.
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Objective: The long-term clinical and radiological outcomes of patients surgically treated for frontal sinus fracture were assessed.

Methods: A retrospective, single-centre analysis was conducted of patients treated for frontal sinus fracture in a tertiary trauma centre between 2000 and 2017. Patients who underwent surgical repair for frontal sinus fracture followed by clinical and radiographical evaluation for at least six months were included.

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Purpose: To study different mask types' impact on a sinonasal quality of life.

Methods: For this observational cross-sectional study, a web-based survey was distributed via social media forums. We used the validated Hebrew version of the Sinonasal Outcome Test-22 followed by a questionnaire developed specifically for the present study, focusing on the time of the COVID-19 pandemic (Mask Sinonasal Outcome Test), and questions regarding general health issues.

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Objective: The extent of surgery, the type of device used and head position may influence nasal irrigation. The aim of this study was to determine the effectiveness of topical irrigant delivery to the paranasal sinuses according to these factors.

Method: Four cadaveric heads underwent four stepwise endoscopic dissections.

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Objective: To evaluate the correlation between the ability to predict the attachment site of sinonasal inverted papilloma by computed tomography and the long-term surgical outcome.

Study Design: Retrospective cohort study.

Setting: Five tertiary medical centers.

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The initial events of viral infection at the primary mucosal entry site following horizontal person-to-person transmission have remained ill defined. Our limited understanding is further underscored by the absence of animal models in the case of human-restricted viruses, such as human cytomegalovirus (HCMV), a leading cause of congenital infection and a major pathogen in immunocompromised individuals. Here, we established a novel model of HCMV infection in native human nasal turbinate tissues.

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Objective: To compare the outcomes of combined endoscopic dacryocystorhinostomy (endoDCR) with nasal septoplasty for deviation of the nasal septum to endoDCR alone in cases of nasolacrimal duct obstruction (NLDO).

Methods: A retrospective cohort study that included 107 consecutive patients with NLDO, who underwent endoDCR with or without concomitant nasal septoplasty in our institution between October 2009 and October 2017.

Results: A total of 117 operations were performed (107 patients, 80.

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Background: Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo. It is assumed that sleep is involved in the pathogenesis of BPPV, and that habitual head-lying side during sleep correlates with the affected side in the posterior semicircular canal BPPV.

Objectives: To investigate the relationship between the preferred sleeping position and the affected semicircular canal in patients with BPPV.

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Objectives/hypothesis: To describe the characteristics and severity of epistaxis in patients taking factor Xa inhibitors novel anticoagulants.

Study Design: Retrospective cohort study.

Methods: A study of adult patients hospitalized due to spontaneous epistaxis under the treatment of warfarin, rivaroxaban, or apixaban between the years 2011 and 2017 was performed.

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Objectives: To investigate bacterial flora of normal maxillary sinuses in order to facilitate perioperative antibiotic management in sinus augmentation procedures.

Materials And Methods: Specimens of maxillary sinus mucosa were harvested during planned orthognatic surgery in 18 patients with no evidence of rhinosinusitis. The samples were processed according to hospital routine for aerobic and anaerobic cultures.

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Background: Several authors highlighted the limitations of the Keros classification system in predicting intracranial entry risk. Recently, our group proposed a new classification system based on the angle formed between the lateral lamella of the cribriform plate (LLCP) and the continuation of an horizontal plane passing through the cribriform plate (Gera classification). The aim of this study was to analyze whether the risk of iatrogenic cerebrospinal fluid leak (CSF-L) was better predicted by Keros or Gera classification.

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Article Synopsis
  • - The study reviewed awake tracheostomy (AT), a procedure for securing airways in patients with upper airway obstructions when other methods fail, based on data from two university-affiliated medical centers between 2010 and 2016.
  • - Out of 1023 tracheostomies, 37 were ATs, primarily due to head and neck malignancies, with the average patient age being 60.3 years and the majority being male; non-oncologic patients were younger and required more urgent interventions.
  • - The findings revealed a 97.3% immediate survival rate for AT, with a 5.4% risk of significant complications and a 2.7% mortality rate, emphasizing
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Purpose: Delayed sinonasal complications of radiation therapy include choanal stenosis, osteoradionecrosis, chronic sinusitis, and intranasal synechiae. Only sporadic cases on their surgical treatment have been reported, with equivocal results.

Methods And Materials: We performed a prospective case series of all patients who had been surgically treated for delayed sinonasal complications of radiation therapy in our institution during the past 10 years.

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Introduction: Early diagnosis of acute invasive fungal rhinosinusitis (AIFR) is crucial for patients prognosis and may reduce the extent of surgical debridement. Initial evaluation usually includes paranasal Computed Tomography (CT), with an emphasis on bony erosion which is considered a specific but insensitive radiologic sign. Most studies made no distinction between Aspergillus and Mucor species while addressing CT findings.

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