Regioselective N1-ribosylation of hydantoin: synthesis and properties of the first contracted uridine analog.

Modified nucleosides are vital in mRNA vaccines. We developed a contracted uridine analog, N1-hydantoinyl-ribose, HR, using steric shields to invert the regioselectivity of the classic Vorbrüggen reaction. We report synthetic routes and explore HR features such as acidity, stability, base pairing/stacking, and crystal/solution conformation compared to uridine.

Innovative functional polymerization of pyrrole-N-propionic acid onto WS nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy.

Tungsten disulfide nanotubes (WS-NTs) were found to be very active for photothermal therapy. However, their lack of stability in aqueous solutions inhibits their use in many applications, especially in biomedicine. Few attempts were made to chemically functionalize the surface of the NTs to improve their dispersability.