Publications by authors named "Yajun Liang"

Background: Motoric cognitive risk (MCR) syndrome as a pre-dementia syndrome often co-occurring with chronic health conditions. This study aims to investigate the prevalence of MCR and its association with cardiometabolic and panvascular multimorbidity among older people living in rural China.

Methods: This population-based study included 1450 participants who were aged ≥ 60 years (66.

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  • DNA methylation is crucial for how plants adjust to stress, especially high temperatures, and the study looked at how it differs between heat-resistant and heat-sensitive plant materials.
  • High-temperature stress led to a decrease in methylation levels of the CG and CHG types, while CHH levels increased, revealing differences between the subgenomes.
  • A total of 124 common differentially methylated genes were identified, with many not affected by DNA methylation in terms of expression, providing insights into the complex regulation of gene expression during temperature stress.
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Introduction: Center-based rehabilitation is limited by COVID-19 infectivity and social distancing policy. We hypothesized that discharged patients benefit from 8-week home-based tele-rehabilitation (tele-PR) using mobile phones and low-cost instruments.

Methods: The TERCOV (Tele-rehabilitation in COVID-19 survivors) is an investigator-initiated, prospective, multi-center, real-world study.

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  • The study investigates how temperature affects the occurrence and spread of a fungal infection in cotton, highlighting its significance in disease management.
  • Through experiments, it was found that the optimal temperature for the fungal pathogen Vd-3 to thrive and form colonies is 25 °C, and that endotoxins extracted from the fungus are most effective at infecting cotton leaves after 48 hours.
  • A total of 34,955 differentially expressed genes were identified in infected cotton leaves, with key focus on genes involved in photosynthesis, sugar metabolism, and defense hormone pathways, establishing a gene regulatory network that could inform potential cotton disease resistance strategies.
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  • The study focused on finding a better way to identify human leucocyte antigens (HLA) and human platelet antigens (HPA) in blood donors.
  • Researchers tested 268 platelet donors using a special long-read sequencing method to see their genetic makeup and how common different alleles are.
  • They discovered new genetic variations in several HPA systems and established a new technique that can help create a better blood platelet donor bank.
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Background: There is limited research providing an overall understanding of bone mineral density (BMD) changes throughout different stages of life. This study aimed to investigate the pattern of BMD changes across childhood, adolescence, adulthood, and old age, as well as exploring the critical time of peak BMD (PBMD).

Methods: Participants of three major ethnicities from National Health and Nutrition Examination Survey 1999 to 2018 were involved: 46,381 and 20,944 participants aged 8-85 years old were included in the Lumbar spine BMD (LSBMD) and femoral neck BMD (FNBMD) studies, respectively.

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Preterm birth (PTB) or small birth size are risk factors for certain neurodevelopmental disorders. The magnitude of these associations in spontaneous births, and of associations for combined PTB and birth size status on neurodevelopmental and psychiatric disorders is unexplored. We investigated whether PTB and small/large for gestational age (SGA/LGA), separately or combined, in spontaneous births, are associated with a wide spectrum of neurodevelopmental and psychiatric disorders.

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Background: The association between gut bacteria and the response to immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC) has been studied; however, multi-kingdom gut microbiome alterations and interactions in ICI-treated HCC cohorts are not fully understood.

Methods: From November 2018 to April 2022, patients receiving ICI treatment for advanced HCC were prospectively enrolled. Herein, we investigated the multi-kingdom microbiota characterization of the gut microbiome, mycobiome, and metabolome using metagenomic, ITS2, and metabolomic data sets of 80 patients with ICI-treated HCC.

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Background: Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used metagenomics and metabolomics to identify characteristics of the gut microbiome and metabolites in immunotherapy-treated BTC and their potential as prognostic and predictive biomarkers.

Methods: This prospective cohort study enrolled 88 patients with BTC who received PD-1/PD-L1 inhibitors from November 2018 to May 2022.

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  • Intrahepatic cholangiocarcinoma (ICC) is a fast-progressing primary liver cancer with a poor outlook and increasing cases worldwide, highlighting the need for better diagnostic and treatment approaches.
  • A case study of a 66-year-old woman showed that despite an initial ineffective chemotherapy, she had a partial response and 9.5 months of progression-free survival after switching to a combination of CDK4/6 inhibitors and immunotherapy.
  • The study suggests this combined treatment is promising but warns about higher thromboembolism rates than seen in trials, raising concerns about preventive measures for patients undergoing CDK4/6 inhibitor therapy.
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γ -aminobutyric acid (GABA) is closely related to the growth, development and stress resistance of plants. Combined with the previous study of GABA to promote the cotton against abiotic stresses, the characteristics and expression patterns of GABA branch gene family laid the foundation for further explaining its role in cotton stress mechanism. Members of GAD, GAB-T and SSADH (three gene families of GABA branch) were identified from the Gossypium hirsutum, Gossypium barbadense, Gossypium arboreum and Gossypium raimondii genome.

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To explore the associations of the metabolic syndrome (MetS) and individual components with macular thickness and volume among rural-dwelling Chinese older adults. This population-based cross-sectional study included 705 participants (age ≥60 years) derived from the MIND-China study. In 2018-2019, we collected data through face-to-face interview, clinical examination, optical coherence tomography (OCT) examination, and blood test.

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Functional genome research, including gene transcriptional and posttranslational modifications of histones, can benefit greatly from a high-quality genome assembly. Histone modification plays a significant role in modulating the responses to abiotic stress in plants. However, there are limited reports on the involvement of dynamic changes in histone modification in cold stress response in upland cotton.

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Background: There is limited evidence on the effect of low birthweight on the use of cardiovascular medications and the role of health behaviors. This study aims to determine the independent effect of low birthweight and its combination with adult health behaviors on the number of dispensed cardiovascular medications.

Methods: We included 15618 participants with information on birthweight and self-reported health behaviors.

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(1) Background: Potentially inappropriate medications (PIMs) in older adults are associated with drug-related problems, adverse health consequences, repeated hospital admissions and a higher risk of mortality. In Saudi Arabia and some Arab countries, studies of PIMs among large cohorts of older adults are limited. This study aimed to determine the prevalence of PIMs, trends and associated factors among outpatient older adults in Saudi Arabia.

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Estrogen receptor (ER)-positive luminal breast cancer is a subtype with generally lower risk of metastasis to most distant organs. However, bone recurrence occurs preferentially in luminal breast cancer. The mechanisms of this subtype-specific organotropism remain elusive.

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Immune checkpoint blockade (ICB) therapy targeting PD-1/PD-L1 has shown durable clinical benefits in lung cancer. However, many patients respond poorly to ICB treatment, underscoring an incomplete understanding of PD-L1 regulation and therapy resistance. Here, we find that MTSS1 is downregulated in lung adenocarcinoma, leading to PD-L1 upregulation, impairment of CD8 lymphocyte function, and enhanced tumor progression.

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  • The study explored how cardiovascular health (CVH) impacts physical function in older adults living in rural China, focusing on inflammatory factors related to health.
  • Researchers assessed a group of 3733 participants aged 65 and older, measuring their physical abilities through various tests and collecting health data through interviews and tests.
  • Findings indicate that having an ideal CVH profile correlates with better physical performance and lower levels of the inflammatory marker IL-6, suggesting inflammation may partly explain the relationship between CVH and physical function.
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FCS-like zinc finger (FLZ) is a plant-specific gene family that plays an important regulatory role in plant growth and development and its response to stress. However, studies on the characteristics and functions of cotton FLZ family genes are still lacking. This study systematically identified members of the cotton FLZ gene family based on cotton genome data.

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Cardiovascular diseases (CVDs) have a high disease burden both globally and in South Africa. They have also been found to be temperature-sensitive globally. The association between temperature and CVD morbidity has previously been demonstrated, but little is known about it in South Africa.

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Purpose: To investigate the individual and the joint effect of impaired fetal growth and adult health behaviors on the risk of cardiovascular diseases (CVDs).

Methods: A total of 15,618 individuals were included from three sub-cohorts of the Stockholm Public Health Cohort. Data on participants' birthweight and gestational age were retrieved from the Medical Birth Register.

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  • * Three main patterns of comorbidity were identified: degenerative-cardiopulmonary, heart-gastrointestinal-psychiatric, and metabolic-kidney diseases, which were linked to increased physical dependence and cognitive impairment post-stroke.
  • * Higher numbers of comorbidities correlated with a greater risk of moderate to severe physical dependence and cognitive issues, emphasizing the need for routine evaluations of comorbid conditions in stroke care.
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Bone is a common site of metastasis in lung cancer, but the regulatory mechanism remains incompletely understood. Osteoclasts are known to play crucial roles in osteolytic bone metastasis by digesting bone matrix and indirectly enhancing tumor colonization. In this study, we found that IL receptor 20 subunit β (IL-20RB) mediated a direct tumoral response to osteoclasts.

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The metabolic syndrome (MetS) has been well linked with coronary heart disease (CHD) in the general population, but studies have rarely explored their association among patients with stroke. We examine prevalence of MetS and its association with CHD in patients with first-ever ischemic stroke. This hospital-based study included 1851 patients with first-ever ischemic stroke (mean age 61.

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Synopsis of recent research by authors named "Yajun Liang"

  • - Yajun Liang's recent research spans various fields, including plant epigenetics and the effects of high-temperature stress on DNA methylation, as well as advancements in tele-rehabilitation for COVID-19 survivors, highlighting a focus on health and environmental interactions.
  • - A significant study investigated the RNA-Seq analysis of temperature stress in cotton plants, providing crucial insights into the interplay between temperature and host-pathogen interactions, which could improve disease management strategies.
  • - Liang's work also delves into the biological underpinnings of neurodevelopmental disorders related to birth factors, and the role of gut microbiota in enhancing immunotherapy responses for cancers, indicating a strong commitment to understanding disease mechanisms and improving therapeutic outcomes.