Interplay of RNA mA Modification-Related Geneset in Pan-Cancer.

: N-methyladenosine (mA), is the most common modification found in mRNA and lncRNA in higher organisms and plays an important role in physiology and pathology. However, its role in pan-cancer has not been explored. : A total of 31 mA modification regulators, including 12 writers, 2 erasers, and 17 readers are identified in the current study.

Measurement of fast-neutron activation cross section of the Ag(n,2n)Ag reaction and its theoretical calculation of excitation function.

The cross section values of the Ag(n,2n)Ag reaction at four neutron energies 13.5, 14.1, 14.

Achieving High Activity and Long-Term Stability towards Oxygen Evolution in Acid by Phase Coupling between CeO-Ir.

The development of efficient and stable catalysts with high mass activity is crucial for acidic oxygen evolution reaction (OER). In this study, CeO-Ir heterojunctions supported on carbon nanotubes (CeO-Ir/CNTs) are synthesized using a solvothermal method based on the heterostructure strategy. CeO-Ir/CNTs demonstrate remarkable effectiveness as catalysts for acidic OER, achieving 10.

EMP3 as a key downstream target of miR-663a regulation interferes with MAPK/ERK signaling pathway to inhibit gallbladder cancer progression.

Gallbladder carcinoma (GBC) is the most common malignancy of the biliary tract, and its molecular pathogenesis remains unclear. Here we explore the functional roles of epithelial membrane protein 3 (EMP3) in GBC progression, which is aberrantly expressed in various types of cancers. The results showed that the expression level of EMP3 was reduced in human GBC tissues compared with non-malignant tissues.

Candida vulturna Outbreak Caused by Cluster of Multidrug-Resistant Strains, China.

Candida vulturna belongs to the Candida haemulonii species complex and is phylogenetically related to C. auris. We report a C.

Boosting Catalytic Selectivity through a Precise Spatial Control of Catalysts at Pickering Droplet Interfaces.

Exploration of new methodologies to tune catalytic selectivity is a long-sought goal in catalytic community. In this work, oil-water interfaces of Pickering emulsions are developed to effectively regulate catalytic selectivity of hydrogenation reactions, which was achieved via a precise control of the spatial distribution of metal nanoparticles at the droplet interfaces. It was found that Pd nanoparticles located in the inner interfacial layer of Pickering droplets exhibited a significantly enhanced selectivity for -chloroaniline (up to 99.

Tri-templating Synthesis of Multilevel Mesoporous Silica Microspheres with a Complex Interior Structure for Efficient CO Capture and Catalysis.

Multilevel porous architectures with microscopic shape control and tailor-made complex structures offer great potential for various innovative applications, but their elaborate design and synthesis have remained a scientific and technological challenge. Herein, we report a simple and effective tri-templating method, in which microscale Pickering droplets, nanoscale polystyrene colloids (PS), and molecular cetyltrimethylammonium chloride micelles are synchronously employed, for the fabrication of such micro-nanohierarchical mesoporous silica microspheres. In this protocol, Pickering droplet-directed interfacial sol-gel growth and its spatially confined surfactant assembly-directed sol-gel coating on PS suspensions are coupled together, enabling the successful formation of structured mesoporous silica that consists of numerous nanocompartments enclosed by a permeable shell.

Early Prediction Model of Acute Aortic Syndrome Mortality in Emergency Departments.

Purpose: Acute aortic syndrome is a constellation of life-threatening medical conditions for which rapid assessment and targeted intervention are important for the prognosis of patients who are at high risk of in-hospital death. The current study aims to develop and externally validate an early prediction mortality model that can be used to identify high-risk patients with acute aortic syndrome in the emergency department.

Patients And Methods: This retrospective multi-center observational study enrolled 1088 patients with acute aortic syndrome admitted to the emergency departments of two hospitals in China between January 2017 and March 2021 for model development.

mA mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway.

Colonic mucosal barrier dysfunction is one of the major causes of inflammatory bowel disease (IBD). However, the mechanisms underlying mucosal barrier dysfunction are poorly understood. -methyladenosine (mA) mRNA modification is an important modulator of epitranscriptional regulation of gene expression, participating in multiple physiological and pathological processes.

Metal-Nanoparticles-Loaded Ultrathin g-CN Nanosheets at Liquid-Liquid Interfaces for Enhanced Biphasic Catalysis.

Exploiting new interface-active solid catalysts is crucial to construct efficient Pickering emulsion systems for biphasic catalysis. In this work, ultrathin g-CN nanosheets (g-CN-NSs) were developed as a new solid emulsifier to directly position catalytic sites at oil-water interfaces for improving the reaction efficiency of a biphasic reaction. Exemplified by a metal-involved biphasic reaction of nitroarenes reduction, the developed Pd/g-CN-NSs catalyst with Pd nanoparticles loaded on the surface of g-CN-NSs exhibited excellent activity with a catalytic efficiency of 1220 h.

Caught in Phase Transition: Snapshot of the Metallofullerene ScN@C Rotation in the Crystal.

The molecular structure of ScN@(7854)-C was determined by single-crystal X-ray diffraction. Variable-temperature X-ray diffraction analysis unraveled the details of the phase transition caused by the temperature-driven jumplike rotation of the fullerene cage between two orientations. Whereas in the lower-temperature 2/ phase the fullerene predominantly occupies one orientation, two orientations become equally occupied in the higher-temperature 2/ phase.

Long noncoding RNA lncGALM increases risk of liver metastasis in gallbladder cancer through facilitating N-cadherin and IL-1β-dependent liver arrest and tumor extravasation.

Background: Long noncoding RNAs (lncRNA) represent significant factors of the mammalian transcriptome that mediates varied biological and pathological processes. The liver is the most common site for gallbladder cancer (GBC) distant metastasis and contributes to the majority of GBC-related death. How lncRNA affects GBC metastasis is not completely understood.

NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma.

NOP2/Sun domain family, member 2 (NSUN2) is a nuclear RNA methyl-transferase catalyzing 5-methylcytosine formation. Evidence shows that NSUN2 is correlated with cell unlimited proliferation. However, its functional role in gallbladder carcinoma (GBC), which is the most common biliary tract malignancy and has a poor prognosis, remains to be determined.

HoO@C: Crystallographic Evidence Showing Linear Metallic Oxide Cluster Encapsulated in IPR Fullerene Cage of (51591)-C.

Fullerene C is the third-most-abundant species after C and C. In the past decade, a variety of C-based clusterfullerenes have been well-studied experimentally, which otherwise do not include oxide clusterfullerenes (OCFs). In this work, we report a comprehensive inspection of HoO@C, including its mass, spectroscopic, crystallographic, electrochemical (EC), and density functional theory (DFT) studies.

Trapping Metallic Oxide Clusters inside Fullerene Cages.

The sub-nanometer sized void inside a fullerene cage permits the accommodation of a single atom, atomic cluster, or even small molecule, resulting in the formation of endohedral fullerenes. Particularly, clusterfullerenes can be formed by encapsulating multiple metallic ions in most cases along with nonmetal ions (i.e.

HoO@C: HoO Cluster Expands within a Small Non-IPR Fullerene Cage of C(13333)-C.

Steering the cluster configuration inside a fullerene cage has been one of most interesting topics in the field of fullerenes, since the physical property of a cluster fullerene may be modified accordingly. It has been well-recognized that the cluster configuration can be tuned via altering the cage size. Typically, the carbide cluster and the oxide cluster are experimentally seen to be curled up within a small fullerene cage whereas they are expanded in a large cage.

ZFX Promotes Proliferation and Metastasis of Pancreatic Cancer Cells via the MAPK Pathway.

Background/aims: The role of ZFX in tumourigenesis is unclear. We aimed to study ZFX expression, regulation, and function and the clinical implications of this protein in human pancreatic cancer (PCa).

Methods: One hundred and twenty patients with histologically confirmed PCa who underwent surgery were recruited for this study.

Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells.

Previous studies have demonstrated that asiatic acid (AA), the major component of , is able to meditate cytotoxic and anticancer effects on various types of carcinoma cells. In order to investigate the molecular mechanism that underlies the antitumor effect of AA, the present study investigated the effects of AA on proliferation, migration and apoptosis of SW480 and HCT116 colon cancer cells. Viability and changes in cell morphology in the cells were assessed by MTT assay and transmission electron microscopy, respectively.

RETRACTED: EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).

The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer.

Gallbladder cancer (GBC) is the most common malignant tumor of the biliary tract system. Epithelial-mesenchymal transition (EMT) plays a vital role in the process of tumor metastasis. Mesenchymal-like cells can serve as a source of cancer stem cells, which can confer the EMT phenotype.

MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7.

Gallbladder carcinoma (GBC), the most common malignant tumour of the bile duct, is highly aggressive and has a poor prognosis. MicroRNA-30a-5p (miR-30a-5p) is an important tumour suppressor that participates in many aspects of carcinogenesis and cancer development. However, the role of miR-30a-5p in GBC development remains to be determined, as do the mechanisms underlying its effects in GBC.

miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma.

Gallbladder cancer (GBC) is the most common malignant tumour of the biliary track system. Angiogenesis plays a pivotal role in the development and progression of malignant tumours. miR-143-3p acts as a tumour suppressor in various cancers.

Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer.

C-terminal Src kinase (Csk)-binding protein (Cbp) is a ubiquitously expressed transmembrane adaptor protein which regulating Src family kinase (SFK) activities. Although SFKs are well known for their involvement in breast cancer, the function of Cbp in breast carcinogenesis upon the adipose-tumor microenvironment has not been investigated. Here, we reported that adipose-derived mesenchymal stem cells (ASCs) induced increased expression of Cbp accompanied by enhanced cell proliferation and chemotherapy resistance in breast cancer cell MCF-7/ADR.