Patterns of recurrence after esophagectomy following neoadjuvant immunochemotherapy in patients with thoracic esophageal squamous cell carcinoma.

Purpose: To explore the recurrence pattern and risk factors associated with the relapse of thoracic esophageal squamous cell carcinoma (TESCC) among patients who received esophagectomy following neoadjuvant immunochemotherapy (NICT).

Methods: A total of 191 TESCC patients who received esophagectomy following NICT were retrospectively reviewed from 2019 to 2022. The first recurrence patterns were assessed.

Prevalence and influencing factors of medication-related burden among patients with late-life depression in typical city of eastern China: a cross-sectional study.

Aim: To evaluate the medication-related burden (MRB) of patients with late-life depression (LLD) and its influencing factors in China using the Living with Medicines Questionnaire-3 (LMQ-3), providing reference for reducing the MRB of those patients.

Method: A cross-sectional study was conducted between September 2023 and January 2024 on 588 patients with LLD. LMQ-3 and MRB factors questionnaire were used for data collection.

Home-based end-of-life care for people with dementia: A systematic review of quantitative and qualitative evidence.

Integrating home-based end-of-life care for people with dementia will become increasingly important as the population ages. Therefore, it is timely and necessary to evaluate the evidence of home-based end-of-life care for people living with dementia. This review aims to identify the characteristics of home-based end-of-life care interventions for people living with dementia and review the existing evidence on implementation outcomes.

Diurnal shifts of rumen fermentation and microbial profiles revealed circadian rhythms of rumen bacteria, methanogens, and protozoa under high-grain and high-forage diets.

In this study, we investigated how the composition and population of rumen microbiota shifted in response to diurnal oscillations under 2 different diets (high grain vs. high forage). Five multiparous Holstein dairy cows with similar BW, DIM, and parity were enrolled in this study.

Analysis of Characteristics of Bovine-Derived Non-Enterotoxigenic and Validation of Potential Probiotic Effects.

is a new generation of probiotics, and its probiotic effects on humans and some animals have been verified. However, research on in cattle is still lacking. In this study, 24 stool samples were collected from two large-scale cattle farms in Wuzhong, Ningxia, including 12 diarrheal and 12 normal stools.

Glioma-Astrocyte connexin43 confers temozolomide resistance through activation of the E2F1/ERCC1 axis.

Background: Glioma is the most prevalent and lethal tumor of the central nervous system. Routine treatment with Temozolomide (TMZ) would unfortunately result in inevitable recurrence and therapy resistance, severely limiting therapeutic efficacy. Tumor associated astrocytes (TAAs) are key components of the tumor microenvironment and increasing evidence has demonstrated that aberrant expression of Connexin43 (Cx43) was closely associated with glioma progression and TMZ resistance.

Deciphering the CNS-glioma dialogue: Advanced insights into CNS-glioma communication pathways and their therapeutic potential.

The field of cancer neuroscience has rapidly evolved, shedding light on the complex interplay between the nervous system and cancer, with a particular focus on the relationship between the central nervous system (CNS) and gliomas. Recent advancements have underscored the critical influence of CNS activity on glioma progression, emphasizing the roles of neurons and neuroglial cells in both the onset and evolution of gliomas. This review meticulously explores the primary communication pathways between the CNS and gliomas, encompassing neuro-glioma synapses, paracrine mechanisms, extracellular vesicles, tunneling nanotubes, and the integrative CNS-immune-glioma axis.

Partitioning Ganoderma lucidum residue biochar differentially boosts anaerobic fermentation performance of cow manure via mediation of anaerobic microbiota assembly.

Biochar is a promising strategy to solve the problem of low efficiency and ammonia inhibition during anaerobic digestion (AD). However, the correlation between biochar partitioning and its stimulatory effects on AD remains uncertain. Here, the effects of partitioned Ganoderma lucidum residue biochar (GLRB) on biogas and methane production were investigated.

Vaping/e-cigarette-induced pulmonary extracellular vesicles contribute to exacerbated cardiomyocyte impairment through the translocation of ERK5.

Aims: The impact of e-cigarettes/vaping on cardiac function remains contradictory owing to insufficient direct evidence of interorgan communication. Extracellular vesicles (EVs) have protective or detrimental effects depending on pathological conditions, making it crucial to understand their role in lung-cardiac cell interactions mediated by vaping inhalation.

Methods And Key Findings: Pulmonary EVs were characterized from animals that underwent 12 weeks of nicotine inhalation (vaping component) (EVs) or vehicle control (EVs).

Molecular-level insights into the leachates released from ultraviolet-aged biodegradable and conventional commercial microplastics and their mechanism of toxicity toward Chlorella pyrenoidosa.

Understanding the harmful effects of microplastics (MPs) and their derivatives is a priority in environmental study. However, the characteristics and toxic effects of leachates from MPs at the molecular-level remain unclear. Herein, two conventional commercial MPs [polystyrene (PS) and polyethylene (PE)] and two biodegradable commercial MPs [polylactic acid (PLA) and polybutylene adipate-co-terephthalate/PLA (PBAT/PLA)] were subjected to leaching under ultraviolet-irradiation, and their leachates were investigated.

Characterization and discrimination of volatile organic compounds and α-glucosidase inhibitory activity of soybeans ( L.) during solid-state fermentation with YL-1.

In this study, the influence of solid-state fermentation (SSF) using probiotic on the change of volatile organic compounds (VOCs) and α-glucosidase inhibition activity of soybeans was investigated. A total of 46 VOCs were characterized via headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS), the majority of which were aldehydes (17), alcohols (10), and ketones (7). SSF by .

Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes.

Background: Occludin, a crucial component of tight junctions, has emerged as a promising biomarker for the diagnosis of acute ischemic disease, highlighting its significant potential in clinical applications. In the diabetes, Occludin serves as a downstream target gene intricately regulated by the adiponectin (APN) signaling pathway. However, the specific mechanism by which adiponectin regulates Occludin expression remains unclear.

Automatic substantia nigra segmentation with Swin-Unet in susceptibility- and T2-weighted imaging: application to Parkinson disease diagnosis.

Background: Accurately distinguishing between Parkinson disease (PD) and healthy controls (HCs) through reliable imaging method is crucial for appropriate therapeutic intervention. However, PD diagnosis is hindered by the subjective nature of the evaluation. We aimed to develop an automatic deep-learning method that can segment the substantia nigra areas on susceptibility-weighted imaging (SWI) and T2-weighted imaging (T2WI) and further differentiate patients with PD from HCs using a machine learning algorithm.

Synergistic Ag/g-CN HO System for Photocatalytic Degradation of Azo Dyes.

Graphitic carbon nitride (g-CN), known for being nontoxic, highly stable, and environmentally friendly, is extensively used in photocatalytic degradation technologies. Silver nanoparticles effectively capture the photogenerated electrons in g-CN, enhancing the photocatalytic efficiency. This study primarily focused on synthesizing graphitic carbon nitride via thermal polymerization and depositing noble metal silver onto g-CN through photoreduction.

Web-Based Dynamic Nomogram for Predicting Risk of Mortality in Heart Failure with Mildly Reduced Ejection Fraction.

Purpose: This study aimed to develop an integrative dynamic nomogram, including N-terminal pro-B type natural peptide (NT-proBNP) and estimated glomerular filtration rate (eGFR), for predicting the risk of all-cause mortality in HFmrEF patients.

Patients And Methods: 790 HFmrEF patients were prospectively enrolled in the development cohort for the model. The least absolute shrinkage and selection operator (LASSO) regression and Random Survival Forest (RSF) were employed to select predictors for all-cause mortality.