Publications by authors named "Yajing Cha"
Reprod Biol Endocrinol
August 2024
Article Synopsis
- Premature ovarian failure (POF) leads to infertility due to the loss of ovarian function, and its molecular causes are not fully understood; this study aimed to explore the protein and metabolite contents in serum extracellular vesicles for potential biomarkers.
- The research involved a comparison of 14 POF patients with 16 healthy controls using advanced proteomic and metabolomic analysis, identifying two patient subgroups and distinguishing metabolic dysfunctions linked to inflammation, oxidative stress, and hormone imbalance in POF.
- The findings highlighted potential biomarkers for POF using ROC curve analysis and machine learning, with AFM and 2-oxoarginine emerging as the most promising diagnostic indicators.
