Meta-analysis and network pharmacology studies of the clinical efficacy of Guizhi Fuling capsules/pills combined with dienogest in treating endometriosis.

Background: Endometriosis (EMs) is a common chronic inflammatory gynecological disease that belongs to the classification of Traditional Chinese Medicine Syndromes "Zheng Jia," and the classic Chinese formula Guizhi Fuling (GZFL) demonstrates significant clinical efficacy in the treatment of this condition. This study aims to investigate GZFL's effect and potential mechanism in EMs.

Methods: The search reviewed randomized controlled trials in 7 databases from inception to 2024, assessed quality with the Cochrane tool, and analyzed data with STATA 15 by 2 reviewers.

High-density, highly sensitive sensor array of spiky carbon nanospheres for strain field mapping.

While accurate mapping of strain distribution is crucial for assessing stress concentration and estimating fatigue life in engineering applications, conventional strain sensor arrays face a great challenge in balancing sensitivity and sensing density for effective strain mapping. In this study, we present a Fowler-Nordheim tunneling effect of monodispersed spiky carbon nanosphere array on polydimethylsiloxane as strain sensor arrays to achieve a sensitivity up to 70,000, a sensing density of 100 pixel cm, and logarithmic linearity over 99% within a wide strain range of 0% to 60%. The highly ordered assembly of spiky carbon nanospheres in each unit also ensures high inter-unit consistency (standard deviation ≤3.

Deciphering the Pharmacological Mechanisms of Wen-Jing-Zhi-Tong Decoction in Treating Primary Dysmenorrhea by UPLC-Q-ExactiveOrbitrap-MS/MS with GC-MS and Network Pharmacology.

Background: Primary dysmenorrhea (PDM) is a prevalent menstrual disorder among women, often underreported and undertreated. Wen-Jing-Zhi-Tong Decoction (WJZTD), a patented Traditional Chinese Medicine (TCM) herbal decoction, has shown efficacy in treating PDM. However, the underlying therapeutic mechanism of WJZTD in PDM treatment remains to be elucidated.

Skin-Integrated Electrodes Based on Room-Temperature Curable, Highly Conductive Silver/Polydimethylsiloxane Composites.

The quality of electrophysiological (EP) signals heavily relies on the electrode's contact with the skin. However, motion or exposure to water can easily destabilize this connection. In contrast to traditional methods of attaching electrodes to the skin surface, this study introduces a skin-integration strategy inspired by the skin's intergrown structure.

A Five-Channel Weighted Real-Time Algorithm for High-Density Electrodes Spike Sorting.

With the application of high-density neural probes, a neuron can be detected by multiple adjacent probes, and the traditional single-channel spike sorting is no longer suitable. In this paper, we propose a five-channel weighted real-time spike sorting algorithm based on template-matching to process neural signals recorded by high-density probes. This work uses the signals of the center channel and the adjacent four channels to form a five-channel template by weighting, and employs a modified OSort algorithm with unsupervised learning to update the template.

Flexible EEG Electrodes with Embedded Pressure Sensors and Customized Interface Towards Comfortable Home EEG Monitoring.

To realize stable and comfortable dry electroencephalography (EEG) recording for home healthcare, a flexible pressure-sensitive electrode (PSE) is proposed, and a dedicated multi-channel pressure sensor interface is developed. The PSE monitors the pressure on the electrode during continuous EEG recording. With the PSE, stable but comfortable electrode-skin contact can be achieved.

A 1.5 mm 4-Channel EEG/BIOZ Acquisition ASIC With 15.2-Bit 3-Step ADC Based on a Signal-Dependent Low-Power Strategy.

This article presents a multichannel EEG/BIOZ acquisition application specific integrated circuit (ASIC) with 4 EEG channels and a BIOZ channel, a switch resistor low-pass filter (SR-LPF). Each EEG channel includes a frontend, and a 4-channel multiplexed analog-to-digital converter (ADC), while the BIOZ channel features a pseudo sine current generator and a pair of readout paths with multiplexed SR-LPF and ADC. The ASIC is designed for size and power minimization, utilizing a 3-step ADC with a novel signal-dependent low power strategy.

An ASIC for Gripper Finger Haptic Force Feedback in Minimally Invasive Surgery.

In this article, we present an application specific integrated circuit (ASIC) for gripper finger haptic force feedback in minimally invasive surgery (MIS). It consists of a driving current source, a sensing channel, a digital to analog converter (DAC), a power management unit (PMU), a clock generator and a digital control unit (DCU). The driving current source features a 6-bit DAC to provide a temperature-insensitive current from 0.

Highly Efficient and Stable Self-Powered Mixed Tin-Lead Perovskite Photodetector Used in Remote Wearable Health Monitoring Technology.

Realization of remote wearable health monitoring (RWHM) technology for the flexible photodiodes is highly desirable in remote-sensing healthcare systems used in space stations, oceans, and forecasting warning, which demands high external quantum efficiency (EQE) and detectivity in NIR region. Traditional inorganic photodetectors (PDs) are mechanically rigid and expensive while the widely reported solution-processed mixed tin-lead (MSP) perovskite photodetectors (PPDs) exhibit a trade-off between EQE and detectivity in the NIR region. Herein, a novel functional passivating antioxidant (FPA) strategy has been introduced for the first time to simultaneously improve crystallization, restrain Sn oxidization, and reduce defects in MSP perovskite films by multiple interactions between thiophene-2-carbohydrazide (TAH) molecules and cations/anions in MSP perovskite.

Strain Release and Defect Passivation in Formamidinium-Dominated Perovskite via a Novel in-Plane Thermal Gradient Assisted Crystallization Strategy.

It is essential to release annealing induced strain during the crystallization process to realize efficient and stable perovskite solar cells (PSCs), which does not seem achievable using the conventional annealing process. Here we report a novel and facile thermal gradient assisted crystallization strategy by simply introducing a slant angle between the preheated hot plate and the substrate. A distinct crystallization sequence resulted along the in-plane direction pointing from the hot side to the cool side, which effectively reduced the crystallization rate, controlled the perovskite grain growth, and released the in-plane tensile strain.

A Flexible and Miniaturized Chest Patch for Real-time PPG/ECG/Bio-Z Monitoring.

We proposed a lightweight and wearable chest patch for real-time monitoring of three vital signals, photoplethysmography (PPG), electrocardiography (ECG), and bioimpedance (Bio-Z). It comprises a flexible electrode patch and a miniaturized wireless signal acquisition module. Heart rate (HR), heart rate variability (HRV), and blood pressure (BP) can be extracted from the raw signals.

A Hardware-based Lightweight ANN for Real-time Wearable Blood Pressure Estimation.

Blood pressure (BP) is an important indicator of the state of cardiovascular health. BP estimation is an essential method to prevent the occurrence of hypertension. Currently, there is a strong focus on low power design for a wearable BP estimation device.

A 17.7µW CDS-CTIA for Wireless-powered Wearable Electrochemical Sweat Sensors.

A capacitor transimpedance amplifier (CTIA) for wireless-powered wearable electrochemical sweat sensors is designed and tested. Correlative double sampling (CDS) technology is utilized to suppress offset voltage and noise. Dedicated low-power and low-voltage designs meet the requirements of wireless-powered wearable applications where the power supply is limited, and voltage is unstable.

Bifunctional flexible fabrics with excellent Joule heating and electromagnetic interference shielding performance based on copper sulfide/glass fiber composites.

Flexible and wearable electronic technology is in great demand with the rise of smart electronic systems. Among these, multifunctional systems with high performance at low cost have attracted extensive attention of scholars from the practical application perspective. However, the fabrication of devices with multifunctionality without sacrificing their connatural flexibility advantages remains a huge challenge.

Quantum effect-based flexible and transparent pressure sensors with ultrahigh sensitivity and sensing density.

Although high-performance flexible pressure sensors have been extensively investigated in recent years owing to their diverse applications in biomedical and information technologies, fabricating ultrasensitive sensors with high pixel density based on current transduction mechanisms still remains great challenging. Herein, we demonstrate a design idea based on Fowler-Nordheim tunnelling effect for fabrication of pressure sensors with ultrahigh sensitivity and sensing density by spin-coating extremely low urchin-like hollow carbon spheres (less than 1.5 wt.

The Optimization of Analog Front-End for Fully Integrated Wearable Sweat Sensor.

The research area of the wearable electrochemical sensors is increasingly growing which are valuable for healthcare and fitness applications owing to their simplicity of operation, low-cost, and compact size. In this work, optimizing of programmable analog front-end for fully integrated wearable sweat sensor is proposed. The proposed system can detect glucose, lactate, sodium, potassium at the same time with low-power consumption which is suitable for continuous real-time sweat sensing system.

A Low Power Cardiovascular Healthcare System With Cross-Layer Optimization From Sensing Patch to Cloud Platform.

Nowadays, cardiovascular disease is still one of the primary diseases that limit life expectation of humans. To address this challenge, this work reports an Internet of Medical Things (IoMT)-based cardiovascular healthcare system with cross-layer optimization from sensing patch to cloud platform. A wearable ECG patch with a custom System-on-Chip (SoC) features a miniaturized footprint, low power consumption, and embedded signal processing capability.

Towards an IoT-based upper limb rehabilitation assessment system.

Rehabilitation of stroke survivors has been increasing in importance in recent years with increase in the occurrence of stroke. However, current clinical classification assessment is time-consuming while the result is not accurate and varies across physicians. This paper introduces an IoT-based upper limb rehabilitation assessment system for stroke survivors based on wireless sensing sub-system, data cloud, computing cloud and software based on Android platform.

[Design of the Mobile ECG Monitoring System Based on Android 4.3].

To monitor and record Electrocardiograph (ECG) signals for 24 hours, a mobile ECG monitoring system is designed based on Android 4.3. In this system, domestic indigenous E9622A is used to acquire ECG signals and TI CC2541 is adopted to communicate with mobile phones.

The application of EMD in activity recognition based on a single triaxial accelerometer.

Activities recognition using a wearable device is a very popular research field. Among all wearable sensors, the accelerometer is one of the most common sensors due to its versatility and relative ease of use. This paper proposes a novel method for activity recognition based on a single accelerometer.

[Design of portable 12-lead digital ECG with low power consumption].

The design of portable and low power consumption 12-lead ECG is based on the digital signal processor TMS320C5515 and the analog front end ADS1298. The ADS1298 collects the ECG signals and deliver them to TMS320C5515. The preprocessed ECG signals are displayed real-time on a LCD and can be stored without compression for a long time.